Treatment of pain with topical diclofenac

Abstract

The field involves compositions useful for pain relief, including diclofenac solution and gel formulations, in particular methods of use thereof, articles of manufacture and kits that provide novel preclinical, clinical and other information to users.

1 .- 20 . (canceled) 
     
     
         21 . A method for treating pain in a patient following an invasive medical procedure or surgery, said method comprising:
 applying a medication consisting of a topical diclofenac preparation to a site of pain and/or to a skin location proximal thereto of said patient, wherein the topical diclofenac preparation consists of 2% w/w of a salt of diclofenac; about 40% to about 50% w/w dimethyl sulfoxide; about 23-29% w/w ethanol; about 10-12% w/w propylene glycol; about 0-6% w/w hydroxypropylcellulose; and water to make 100% w/w;   wherein the topical diclofenac preparation has a viscosity of 500-5000 centipoise, and   wherein said medication is applied twice daily.   
     
     
         22 . The method according to  claim 21 , wherein said salt of diclofenac is selected from a sodium salt, a potassium salt, a diethylamine salt, and an epolamine salt. 
     
     
         23 . The method according to  claim 21 , wherein said salt of diclofenac is diclofenac sodium. 
     
     
         23 . The method according to  claim 21 , wherein said dimethyl sulfoxide is present at 45.5% w/w. 
     
     
         24 . A method for treating pain in a supporting body structure of a patient, said method comprising:
 applying a medication consisting of a topical diclofenac preparation to a site of pain of said patient, wherein the topical diclofenac preparation consists of 2% w/w of a salt of diclofenac; about 40% to about 50% w/w dimethyl sulfoxide; about 23-29% w/w ethanol; about 10-12% w/w propylene glycol; about 0-6% w/w hydroxypropylcellulose; and water to make 100% w/w;   wherein the topical diclofenac preparation has a viscosity of 500-5000 centipoise,   wherein said medication is applied twice daily, and   wherein the supporting body structure is selected from muscles, bones, tendons, ligaments and cartilage.   
     
     
         25 . The method according to  claim 24 , wherein said dimethyl sulfoxide is present at 45.5% w/w. 
     
     
         26 . The method according to  claim 24 , wherein said salt of diclofenac is selected from a sodium salt, a potassium salt, a diethylamine salt, and an epolamine salt. 
     
     
         27 . The method according to  claim 24 , wherein said salt of diclofenac is diclofenac sodium.