Nitroxyl progenitors in the treatment of heart failure

Abstract

Administration of an HNO/NO − donating compound, such as Angeli's salt, increases myocardial contractility while concomitantly lowering left ventricular preload in subjects experiencing heart failure. Moreover, administration of the HNO/NO − donating compound isopropylamine (IPA)/NO (Na(CH 3 ) 2 CHNHN(O)NO) surprisingly exhibited positive inotropic effects in subjects experiencing heart failure that were superior to those caused by the HNO/NO − donating compound Angeli's salt. Additionally, in contrast to the effects observed with NO· donors, administration of an HNO/NO − donor in combination with a positive inotropic agent did not impair the positive inotropic effect of the positive inotropic agent. Further, HNO/NO − exerts its positive inotropic effect independent of the adrenergic system, increasing contractility even in subjects receiving beta-antagonist therapy.

1 . A method of treating heart failure comprising,
 Administering to a subject experiencing heart failure, a therapeutically effective dose of at least one nitroxyl donating compound and at least one positive inotropic compound, wherein the does is effective to increase myocardial contractility.   
     
     
         2 - 25 . (canceled)