US2016229897A1PendingUtilityA1

Hepatitis b virus vaccines

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Assignee: ALTRAVAX INCPriority: Mar 14, 2013Filed: Apr 26, 2016Published: Aug 11, 2016
Est. expiryMar 14, 2033(~6.7 yrs left)· nominal 20-yr term from priority
Inventors:Robert WhalenClayton BeardLi XuHakima Sbai
C12N 2730/10122C12N 2730/10134C12N 7/00A61K 2039/53C07K 14/005A61P 31/20
42
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Claims

Abstract

This document provides methods and materials for producing immune responses against hepatitis B viruses. For example, polypeptides, nucleic acid molecules encoding such polypeptides, virus-like particles containing such polypeptides, vaccine preparations containing one or more polypeptides provided herein, vaccine preparations containing one or more nucleic acid molecules provided herein, vaccine preparations containing one or more virus-like particles provided herein, and methods for inducing immune responses against hepatitis B viruses within mammals (e.g., humans) are provided.

Claims

exact text as granted — not AI-modified
1 - 5 . (canceled) 
     
     
         6 . A nucleic acid molecule comprising a nucleic acid sequence encoding a polypeptide comprising an amino acid sequence, wherein said amino acid sequence is at least 97 percent identical to the amino acid sequence set forth in SEQ ID NO:18. 
     
     
         7 . The nucleic acid molecule of  claim 6 , wherein said amino acid sequence is at least 98 percent identical to the amino acid sequence set forth in SEQ ID NO:18. 
     
     
         8 . The nucleic acid molecule of  claim 6 , wherein said amino acid sequence is at least 99 percent identical to the amino acid sequence set forth in SEQ ID NO:18. 
     
     
         9 . A nucleic acid molecule comprising a nucleic acid sequence encoding a polypeptide comprising an amino acid sequence, wherein said amino acid sequence is at least 96 percent identical to the amino acid sequence set forth in SEQ ID NO:14. 
     
     
         10 . The nucleic acid molecule of  claim 9 , wherein said amino acid sequence is at least 97 percent identical to the amino acid sequence set forth in SEQ ID NO:14. 
     
     
         11 . The nucleic acid molecule of  claim 9 , wherein said amino acid sequence is at least 98 percent identical to the amino acid sequence set forth in SEQ ID NO:14. 
     
     
         12 . The nucleic acid molecule of  claim 9 , wherein said amino acid sequence is at least 99 percent identical to the amino acid sequence set forth in SEQ ID NO:14. 
     
     
         13 . A nucleic acid molecule comprising a nucleic acid sequence encoding a polypeptide comprising an amino acid sequence, wherein said amino acid sequence is at least 97 percent identical to the amino acid sequence set forth in SEQ ID NO:22. 
     
     
         14 . The nucleic acid molecule of  claim 13 , wherein said amino acid sequence is at least 98 percent identical to the amino acid sequence set forth in SEQ ID NO:22. 
     
     
         15 . The nucleic acid molecule of  claim 13 , wherein said amino acid sequence is at least 99 percent identical to the amino acid sequence set forth in SEQ ID NO:22. 
     
     
         16 . A nucleic acid molecule comprising a nucleic acid sequence encoding a polypeptide comprising an amino acid sequence, wherein said amino acid sequence is at least 95 percent identical to the amino acid sequence set forth in SEQ ID NO:28. 
     
     
         17 . The nucleic acid molecule of  claim 16 , wherein said amino acid sequence is at least 96 percent identical to the amino acid sequence set forth in SEQ ID NO:28. 
     
     
         18 . The nucleic acid molecule of  claim 16 , wherein said amino acid sequence is at least 97 percent identical to the amino acid sequence set forth in SEQ ID NO:28. 
     
     
         19 . The nucleic acid molecule of  claim 16 , wherein said amino acid sequence is at least 98 percent identical to the amino acid sequence set forth in SEQ ID NO:28. 
     
     
         20 . The nucleic acid molecule of  claim 16 , wherein said amino acid sequence is at least 99 percent identical to the amino acid sequence set forth in SEQ ID NO:28. 
     
     
         21 . A nucleic acid molecule comprising a nucleic acid sequence encoding a polypeptide comprising an amino acid sequence, wherein said amino acid sequence is at least 96 percent identical to the amino acid sequence set forth in SEQ ID NO:12. 
     
     
         22 . The nucleic acid molecule of  claim 21 , wherein said amino acid sequence is at least 97 percent identical to the amino acid sequence set forth in SEQ ID NO:12. 
     
     
         23 . The nucleic acid molecule of  claim 21 , wherein said amino acid sequence is at least 98 percent identical to the amino acid sequence set forth in SEQ ID NO:12. 
     
     
         24 . The nucleic acid molecule of  claim 21 , wherein said amino acid sequence is at least 99 percent identical to the amino acid sequence set forth in SEQ ID NO:12.

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