Modular surface functionalization of polyisobutylene-based materials

Abstract

A polymer composite includes a functionalized polyisobutylene and an additional polyisobutylene-containing material. One or more methods of making the polymer composite are also provided. Where the functionalized polyisobutylene is applied to a polyisobutylene-containing material, the method of applying the functionalized polyisobutylene compound can be described as a modular method.

What is claimed is: 
     
         1 . A polymer composite comprising a functionalized polyisobutylene and an additional polyisobutylene-containing material. 
     
     
         2 . The composite of  claim 1 , wherein said functionalized polyisobutylene and said additional polyisobutylene-containing material are not attached by a covalent bond. 
     
     
         3 . The composite of  claim 1 , wherein said additional polyisobutylene-containing material is non-functionalized. 
     
     
         4 . The composite of  claim 1 , wherein said functionalized polyisobutylene includes a functional group selected from the group consisting of hydroxyl group, alkyl alcohols, ethylene glycol, oligomers of ethylene glycol, poly(ethylene glycol), poly(ethylene oxide), α-lipoic acid, amino acids, nucleic acids, saccharides, tocopherols, carotenoids, phosphatidylcholine, and combinations thereof. 
     
     
         5 . The composite of  claim 1 , wherein the functional group includes a hydroxyl group. 
     
     
         6 . The composite of  claim 1 , wherein the functional group includes α-lipoic acid. 
     
     
         7 . The composite of  claim 5 , wherein said functionalized polyisobutylene further includes poly(ethylene glycol). 
     
     
         8 . The composite of  claim 1 , wherein said additional polyisobutylene-containing material is selected from the group consisting of linear polyisobutylene TPEs, star polyisobutylene TPEs, and arborescent polyisobutylene TPEs. 
     
     
         9 . The composite of  claim 1 , wherein said additional polyisobutylene-containing material is selected from the group consisting of linear poly(isobutylene(OH)-b-(isobutylene-co-para-methylstyrene)s, star poly(isobutylene(OH)-b-(isobutylene-co-para-methylstyrene)s, arborescent poly(isobutylene(OH)-b-(isobutylene-co-para-methylstyrene)s, linear poly(styrene-b-isobutylene-b-styrene)s, star poly(styrene-b-isobutylene-b-styrene)s, arborescent poly(styrene-b-isobutylene-b-styrene)s, linear poly(isobutylene-OH-co-para-methylstyrene), star poly(isobutylene-OH-co-para-methylstyrene), arborescent poly(isobutylene-OH-co-para-methylstyrene), linear poly(alloocimene-b-isobutylene-b-alloocimene), star poly(alloocimene-b-isobutylene-b-alloocimene), and arborescent poly(alloocimene-b-isobutylene-b-alloocimene). 
     
     
         10 . The composite of  claim 1 , the composite being coated on a substrate. 
     
     
         11 . The composite of  claim 10 , wherein said substrate is selected from the group consisting of a breast implant, a stent, a knee implant, a catheter, and a wire. 
     
     
         12 . The composite of  claim 10 , wherein said substrate is a biocompatible material. 
     
     
         13 . The composite of  claim 10 , wherein the composite has a protein adsorption of less than 50 ng/cm 2  with respect to the protein fibrinogen. 
     
     
         14 . The composite of  claim 10 , wherein the composite includes a drug or molecule attached to the surface. 
     
     
         15 . A method for producing the polymer composite of  claim 1 , where the additional polyisobutylene-containing material is a substrate having a surface, the method comprising the step of coating the surface of the substrate with the functionalized polyisobutylene. 
     
     
         16 . The method of  claim 15 , where the step of coating includes spray coating the functionalized polyisobutylene on to the surface of the substrate. 
     
     
         17 . The method of  claim 15 , where the step of coating includes dipping the surface of the substrate in a solution containing the functionalized polyisobutylene. 
     
     
         18 . A method for producing the polymer composite of  claim 1 , comprising the steps of
 providing a polymer combination comprising the functionalized polyisobutylene and the additional polyisobutylene-containing material, and   depositing the polymer combination on to a substrate.   
     
     
         19 . The method of  claim 18 , where the step of depositing is electrospraying. 
     
     
         20 . The method of  claim 18 , where the step of depositing is electrospinning.