Control of Blood Vessel Physiology To Treat Skin Disorders

Abstract

In a method for treating an affected skin region of a patient having a skin disorder, a vasodilation composition is applied to an affected skin region of a patient, the affected skin region exhibiting a skin disorder characterized by at least one abnormal blood vessel, and the affected skin region is then treated so as to non-invasively disrupt tissue architecture, e.g., by inducing ischemia, of the at least one abnormal blood vessel. A vasoconstriction composition can then be applied to the skin region to cause vasoconstriction of the at least one blood vessel in order to promote healing.

1 . A method for treating an affected skin region of a patient having a skin disorder, the method comprising:
 a) applying a vasodilation composition to an affected skin region of a patient, said affected skin region exhibiting a skin disorder characterized by at least one abnormal blood vessel, wherein said blood vessel comprises a tissue architecture,   b) waiting for a time sufficient to allow vasodilation of said at least one abnormal blood vessel in said affected skin region;   c) non-invasively disrupting the tissue architecture of said vasodilated at least one abnormal blood vessel; and   d) subsequent to disrupting the tissue architecture, applying a vasoconstriction composition to the affected skin region so as to cause vasoconstriction and collapse of the at least one abnormal blood vessel.