Novel Epitope for Switching to Th17 Cell and Use Thereof

Abstract

The present invention relates to a novel epitope to convert T cell to type 17 helper T (T H 17) cell. Specifically, the present invention relates to an epitope constituting the 41 st to 50 th amino acids (SEQ ID No. 2) of extracellular domain (ECD) of activation-inducible tumor necrosis factor receptor (AITR), an antibody recognizing the epitope, a polynucleotide encoding the epitope, a polynucleotide encoding the antibody, an expression vector comprising the polynucleotide encoding the epitope or antibody, a transformant introduced with the vector, a composition comprising the antibody for converting T cell to T H 17 cell and a method of conversion for the same, a pharmaceutical composition comprising the antibody for preventing or treating infectious disease, a method for treating infectious disease using the antibody, a composition comprising the antibody for enhancing immunity, and a method for enhancing immunity using the antibody.

1 . A polypeptide which is an epitope of activation-inducible tumor necrosis factor receptor (AITR), defined as an amino acid sequence represented by SEQ ID No. 2, for converting T cell to type 17 helper T (T H 17) cell. 
     
     
         2 . A polynucleotide encoding the polypeptide of  claim 1 .