Method for determining severity and progression of periodontal disease

Abstract

An improved method and kit of determining whether a patient is predisposed to having severe periodontal disease and/or having high risk of progression of periodontal disease, comprising the steps of (i) taking a biological sample from said patient; (ii) genotyping said biological sample for genetic polymorphism pattern comprising IL 1B (rs16944), IL 1B (rs1143623) and IL 1B (rs4848306); and (iii) comparing said genetic polymorphism patterns to a reference composite genotype pattern; wherein the similarity of said genetic polymorphism patterns to said reference pattern indicate said patient's predisposition to having severe periodontal disease and/or having high risk of progression of periodontal disease.

What is claimed is: 
     
         1 . A method of determining whether a patient is predisposed to having severe periodontal disease and/or having high risk of progression of periodontal disease, comprising the steps of:
 (i) taking a biological sample from said patient;   (ii) genotyping said biological sample for genetic polymorphism pattern comprising IL 1B (rs16944), IL 1B (rs1143623) and IL 1B (rs4848306);   (iii) comparing said genetic polymorphism pattern to a reference composite genotype pattern, wherein the similarity of said genetic polymorphism pattern to said reference pattern indicate said patient's predisposition to having severe periodontal disease and/or having high risk of progression of periodontal disease.   
     
     
         2 . The method of  claim 1 , wherein said biological sample is saliva, buccal cells, blood, tissue samples or urine. 
     
     
         3 . The method of  claim 1 , wherein said genetic polymorphism pattern further comprises IL 1B (rs1143633). 
     
     
         4 . The method of  claim 1  for determining whether said patient is predisposed to having severe periodontal disease. 
     
     
         5 . The method of  claim 1  for determining said patient's risk of progression of periodontal disease. 
     
     
         6 . The method of  claim 1 , wherein said patient is Caucasian, African, Chinese or other ethnicities. 
     
     
         7 . A testing kit for determining whether a patient is predisposed to having severe periodontal disease and/or having high risk of progression of periodontal disease, comprising:
 (i) biological sample collection means;   (ii) a means for determining genetic polymorphism pattern comprising IL 1B (rs16944), IL 1B (rs1143623) and IL 1B (rs4848306); and   (iii) a control sample as a reference.   
     
     
         8 . The test kit of  claim 7 , wherein said genetic polymorphism pattern further comprises IL 1B (rs1143633). 
     
     
         9 . The test kit of  claim 6 , wherein said patient is Caucasian, African, Chinese or of other ethnicities.