Nitric oxide generation, dilution, and topical application apparatus and method

Abstract

An apparatus for controlled delivery of nitric oxide. A pump draws air through an activated carbon filter and into a reaction chamber. The generation of nitric oxide occurs in the reaction chamber. A second pump draws the gas in the reaction chamber through a calcium hydroxide filter and delivers the nitric oxide through an orifice, or aperture, that controls the flow of nitric oxide delivered. The nitric oxide is filtered through a calcium hydroxide filter just prior to being made available for various nitric oxide therapies. Topical applications that provide a nitric oxide therapy to a surface are also provided.

What is claimed and desired to be secured by United States Letters Patent is: 
     
         1 - 15 . (canceled) 
     
     
         16 . A nitric oxide gas generator, comprising:
 a first pump in fluid communication with a first filter and an inlet of a reaction chamber wherein the first filter is capable of filtering oxygen and moisture;   the reaction chamber having at least the inlet and an outlet and containing a first reactant in a solid form, a second reactant in a solid form, and a third reactant in a solid form that when combined and heated are capable of producing a nitric oxide gas;   a heating element connected to the reaction chamber wherein the heating element is capable of heating the reaction chamber in a manner sufficient to heat the reactants and initiate the production of the nitric oxide gas; and   the outlet in fluid communication with the reaction chamber, the atmosphere outside the apparatus and a second pump wherein the second pump is capable of drawing the nitric oxide gas out of the reaction chamber.   
     
     
         17 . The nitric oxide generator of  claim 16 , wherein the second pump is in fluid communication with a second filter and an aperture; and
 the aperture is in fluid communication with a delivery line.   
     
     
         18 . The nitric oxide generator of  claim 16 , wherein the first reactant is approximately 2.3 g of calcined chromium oxide (Cr2O3), the second reactant is approximately 1.6 g of sodium nitrite (NaNO2), and the third reactant is approximately 0.65 g of sodium nitrate (NaNO3). 
     
     
         19 . The nitric oxide generator of  claim 16 , wherein the first filter is an activated carbon filter and the second filter is a calcium hydroxide filter. 
     
     
         20 . The nitric oxide generator of  claim 16 , further comprising a third filter in fluid communication with the delivery line. 
     
     
         21 . The nitric oxide generator of  claim 16 , wherein the reaction chamber further comprises fins that are connected to an outside wall of the reaction chamber and to the heating element. 
     
     
         22 . The nitric oxide generator of  claim 21 , wherein the fins are connected to the outside wall of the reaction chamber and to a heat cartridge sleeve. 
     
     
         23 . The nitric oxide generator of  claim 16 , further comprising an analyzer capable of measuring a concentration of the nitric oxide gas. 
     
     
         24 . A nitric oxide gas generator, comprising:
 a first pump in fluid communication with a first filter and an inlet of a reaction chamber wherein the first pump is capable of pressurizing the reaction chamber and the first filter is capable of filtering oxygen and moisture;   the reaction chamber having at least the inlet and an outlet and containing a granulated mixture of reactants, wherein the granulated mixture is capable of passing through a five micron screen and comprises an effective amount of calcined chromium oxide, a nitrite compound, and a nitrate compound, that when combined and heated are capable of producing a nitric oxide gas;   a heating element connected to the reaction chamber wherein the heating element is capable of heating the reaction chamber in a manner sufficient to heat the reactants and initiate the production of the nitric oxide gas;   the outlet in fluid communication with the reaction chamber, the atmosphere outside the apparatus and a second pump;   the second pump in fluid communication with a second filter and an aperture wherein the second pump is capable of drawing the nitric oxide gas out of the reaction chamber and pumping the nitric oxide gas through the aperture; and   the aperture in fluid communication with a delivery line.   
     
     
         25 . The nitric oxide generator of  claim 24 , wherein the reaction chamber further comprises fins that are connected to an outside wall of the reaction chamber and to the heating element. 
     
     
         26 . The nitric oxide generator of  claim 25 , wherein the fins are connected to the outside wall of the reaction chamber and to a heat cartridge sleeve. 
     
     
         27 . The nitric oxide generator of  claim 24 , further comprising an analyzer capable of measuring a concentration of the nitric oxide gas. 
     
     
         28 . The nitric oxide generator of  claim 24 , further comprising a cooler capable of cooling the nitric oxide gas after the nitric oxide gas is drawn out of the reaction chamber. 
     
     
         29 . A nitric oxide gas generator, comprising:
 a first pump in fluid communication with a first filter and an inlet of a reaction chamber wherein the first pump is capable of pressurizing the reaction chamber and the first filter is capable of filtering oxygen and moisture;   the reaction chamber having at least the inlet and an outlet and containing a first reactant in a solid form, a second reactant in a solid form, and a third reactant in a solid form that when combined and heated are capable of producing a nitric oxide gas;   a heating element connected to the reaction chamber wherein the heating element is capable of heating the reaction chamber in a manner sufficient to heat the reactants and initiate the production of the nitric oxide gas;   the reaction chamber further comprises fins that are connected to an outside wall of the reaction chamber and to the heating element such that the fins are capable of dissipating heat through the reaction chamber;   the outlet in fluid communication with the reaction chamber, the atmosphere outside the apparatus and a second pump;   the second pump in fluid communication with a second filter and an aperture wherein the second pump is capable of drawing the nitric oxide gas out of the reaction chamber and pumping the nitric oxide gas through the aperture; and   the aperture in fluid communication with a delivery line.   
     
     
         30 . The nitric oxide generator of  claim 29 , wherein the fins are connected to the outside wall of the reaction chamber and to a heat cartridge sleeve. 
     
     
         31 . The nitric oxide generator of  claim 29 , wherein the reactants further comprise 51% w/w of calcine chromium oxide (Cr203), 34.7% w/w of sodium nitrite (NaNO2), and 14.4% of sodium nitrate (NaNO3). 
     
     
         32 . The nitric oxide generator of  claim 29 , further comprising an analyzer capable of measuring a concentration of the nitric oxide gas. 
     
     
         33 . The nitric oxide generator of  claim 29 , further comprising a cooler capable of cooling the nitric oxide gas after the nitric oxide gas is drawn out of the reaction chamber.