Methods and devices for endovascular embolization

Abstract

The present disclosure describes an occlusion device and methods of delivering the occlusion device. The occlusion device can include an expandable structure configured to move between an unexpanded configuration and an expanded configuration. The expandable structure can be configured to have an expansion ratio of at least about 5:1. Further, the occlusion device can be configured to prevent substantially all fluid from flowing past the occlusion device when the occlusion device is in the expanded configuration in the vessel.

1 - 87 . (canceled) 
     
     
         88 . A resheathable, repositionable vascular occlusion device, comprising:
 a frame, expandable from a constrained configuration to an unconstrained configuration, the frame comprising:
 a proximal embolic zone expandable to include a radially outwardly flared side wall portion having a first outwardly concave curvature; 
 a distal anchoring zone expandable to include a radially outwardly flared side wall portion having a second outwardly concave curvature; and 
 a central portion between the proximal embolic zone and the distal anchoring zone; 
   wherein a radius of a best fit circle conforming to the first outwardly concave curvature is less than a radius of a best fit circle conforming to the second outwardly concave curvature such that the frame is configured to reduce the force necessary to retract the distal anchoring zone into a delivery system.   
     
     
         89 . The vascular occlusion device of  claim 88 , wherein a wall pattern of the frame comprises bilateral symmetry in the constrained configuration and bilateral asymmetry in the unconstrained configuration. 
     
     
         90 . The vascular occlusion device of  claim 88 , wherein:
 the radially outwardly flared sidewall portion of the proximal embolic zone comprises a plurality of proximal struts, each proximal strut comprising an arc having a midpoint, and   the radially outwardly flared sidewall portion of the distal anchoring zone comprises a plurality of distal struts, each distal strut comprising an arc having a midpoint, the midpoint of one of said distal struts being a greater radial distance from a longitudinal axis of the frame than the midpoint of one of said proximal struts.   
     
     
         91 . The vascular occlusion device of  claim 88 , wherein the radius of the best fit circle conforming to the second outwardly concave curvature is at least about 25% of a largest diameter of the distal anchoring zone in the unconstrained configuration. 
     
     
         92 . The vascular occlusion device of  claim 91 , wherein the radius of the best fit circle conforming to the second outwardly concave curvature is at least about 35% of the largest diameter of the distal anchoring zone in the unconstrained configuration. 
     
     
         93 . The vascular occlusion device of  claim 88 , wherein the radius of the best fit circle conforming to the first outwardly concave curvature is less than about 25% of a largest diameter of the proximal embolic zone in the unconstrained configuration. 
     
     
         94 . The vascular occlusion device of  claim 93 , wherein the radius of the best fit circle conforming to the first outwardly concave curvature is less than about 15% of the largest diameter of the proximal embolic zone in the unconstrained configuration. 
     
     
         95 . A vascular occlusion device comprising:
 a frame expandable from a constrained configuration to an unconstrained configuration, the frame comprising:
 a proximal embolic zone expandable comprising a proximal tissue contacting portion, a first tapered portion, and a first transition point between the proximal tissue contacting portion and the first tapered portion; 
 a distal anchoring zone comprising a distal tissue contacting portion, a second tapered portion, and a second transition point between the distal tissue contacting portion and the second tapered portion; and 
 a central portion between the proximal embolic zone and the distal anchoring zone; 
   a first angle measured from a line extending through the first transition point and an axial center of the central portion to a longitudinal axis of the vascular occlusion device when the frame is in the unconstrained configuration;   a second angle measured from a line extending through the second transition point and the axial center of the central portion to the longitudinal axis of the vascular occlusion device when the frame is in the unconstrained configuration;   wherein the second angle is less than the first angle such that the frame is configured to reduce the force necessary to retract the distal anchoring zone into a delivery system.   
     
     
         96 . The vascular occlusion device of  claim 95 , wherein a wall pattern of the frame comprises bilateral symmetry in the constrained configuration and bilateral asymmetry in the unconstrained configuration. 
     
     
         97 . The vascular occlusion device of  claim 95 , wherein the first tapered portion comprises a first outwardly concave curvature, and wherein the second tapered portion comprises a second outwardly concave curvature. 
     
     
         98 . The vascular occlusion device of  claim 97 , wherein:
 the first tapered portion of the proximal embolic zone comprises a plurality of proximal struts, each proximal strut having a launch angle between a curved axis of said proximal strut and a longitudinal axis of the frame;   the second tapered portion of the distal anchoring zone comprises a plurality of distal struts, each distal strut having a launch angle between a curved axis of said distal strut and the longitudinal axis of the frame; and   the launch angle of each proximal strut is steeper than the launch angle of each distal strut.   
     
     
         99 . The vascular occlusion device of  claim 98 , wherein:
 each proximal strut comprises a tapered portion between the curved axis of said proximal strut and the first transition point, a first tapered angle being measured between the tapered portion of said proximal strut and the longitudinal axis of the frame; and   each distal strut comprises a tapered portion between the curved axis of said distal strut and the second transition point, a second tapered angle being measured between the tapered portion of said distal strut and the longitudinal axis of the frame, the first tapered angle being substantially the same as the second tapered angle.   
     
     
         100 . The vascular occlusion device of  claim 99 , wherein each of the first tapered angle and the second tapered angle is between about 45 degrees and about 75 degrees.