Biologic replacement for fibrin clot

Abstract

The invention provides composition and methods for repairing a ruptured anterior cruciate ligament.

1 . A scaffold for repair of a tissue defect in comprising a three-dimensional matrix adapted to facilitate cell in-growth, wherein said matrix is shaped for implantation into a patient at the site of the tissue defect, wherein said matrix comprises a natural matrix material wherein the natural matrix material is a collagen glycosaminoglycan copolymer comprised of collagen type I, and wherein said scaffold further comprises plasma. 
     
     
         2 . The scaffold according to  claim 1 , wherein the tissue defect is extra-articular. 
     
     
         3 . The scaffold according to  claim 1 , wherein said tissue defect is intra-articular. 
     
     
         4 . The scaffold according to  claim 1 , wherein said tissue defect comprises a ligament. 
     
     
         5 . The scaffold according to  claim 1 , wherein said tissue defect comprises a tendon. 
     
     
         6 . The scaffold according to  claim 1 , wherein said tissue defect comprises bone. 
     
     
         7 . A scaffold for repair of a tissue defect in comprising a three-dimensional matrix adapted to facilitate cell in-growth, wherein said matrix is shaped for implantation into a patient at the site of the tissue defect, wherein said matrix comprises a natural matrix material wherein the natural matrix material is a collagen glycosaminoglycan copolymer comprised of collagen type I, and wherein said scaffold further comprises a platelet. 
     
     
         8 . The scaffold according to  claim 7 , wherein said tissue defect is extra-articular. 
     
     
         9 . The scaffold according to  claim 7 , wherein said tissue defect is intra-articular. 
     
     
         10 . The scaffold according to  claim 7 , wherein said tissue defect comprises a ligament. 
     
     
         11 . The scaffold according to  claim 7 , wherein said tissue defect comprises a tendon. 
     
     
         12 . A scaffold for repair of a tissue defect in comprising a three-dimensional matrix adapted to facilitate cell in-growth, wherein said matrix is shaped for implantation into a patient at the site of the tissue defect, wherein said matrix comprises a natural matrix material wherein the natural matrix material is a collagen glycosaminoglycan copolymer comprised of collagen type I, and wherein said scaffold further comprises a neutralizing agent. 
     
     
         13 . The scaffold according to  claim 12 , wherein said tissue defect is extra-articular. 
     
     
         14 . The scaffold according to  claim 12 , wherein said tissue defect is intra-articular. 
     
     
         15 . The scaffold according to  claim 12 , wherein said tissue defect is a partial or complete tear of a ligament. 
     
     
         16 . The scaffold according to  claim 12 , wherein said tissue defect is a partial or complete tear of an anterior cruciate ligament (ACL). 
     
     
         17 . The scaffold according to  claim 12 , wherein said tissue defect is a partial or complete tear of the rotator cuff. 
     
     
         18 . The scaffold according to  claim 12 , wherein said tissue defect is a partial or complete tear of the labrum. 
     
     
         19 . The scaffold according to  claim 12 , wherein said tissue defect is a partial or complete tear of the meniscus.