US2016271104A1PendingUtilityA1

Small molecule, indirubin-3-oxime, for prevention and treatment of bone disease

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Assignee: INDUSTRY-ACADEMIC COOPERATION FOUNDATION YONSEI UNIVPriority: Jul 11, 2013Filed: Jul 10, 2014Published: Sep 22, 2016
Est. expiryJul 11, 2033(~7 yrs left)· nominal 20-yr term from priority
Inventors:Kang-Yell ChoiHyun-Yi KimSehee Choi
A23L 2/52A61K 31/404A23L 33/10A23L 33/105A61P 19/00A23V 2002/00A23L 1/3002A61K 31/403
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Claims

Abstract

The present invention provides a composition comprising an indirubin derivative for stimulating longitudinal bone growth. Because the composition for stimulating longitudinal bone growth according to the present invention is shown to be effective in longitudinal bone growth, it may be used not only as a composition for stimulating longitudinal bone growth, but also as a pharmaceutical composition for treating or preventing short stature, microplasia, dwarfism, or precocious puberty.

Claims

exact text as granted — not AI-modified
1 . A composition comprising an indirubin derivative for stimulating longitudinal bone growth. 
     
     
         2 . The composition according to  claim 1 , wherein the indirubin derivative is indirubin-3′-oxime. 
     
     
         3 . The composition according to  claim 1 , wherein the longitudinal bone growth is an increase in the length of the tibia. 
     
     
         4 . The composition according to  claim 1 , wherein the longitudinal bone growth is an increase in the activity of the growth plate. 
     
     
         5 . A pharmaceutical composition comprising an indirubin derivative for treating or preventing longitudinal bone growth disorders. 
     
     
         6 . The pharmaceutical composition according to  claim 5 , wherein the indirubin derivative is indirubin-3′-oxime. 
     
     
         7 . The pharmaceutical composition according to  claim 5 , wherein the longitudinal bone growth disorder is short stature, microplasia, dwarfism, or precocious puberty. 
     
     
         8 . A food composition comprising an indirubin derivative for improving longitudinal bone growth. 
     
     
         9 . The food composition according to  claim 8 , wherein the indirubin derivative is indirubin-3′-oxime. 
     
     
         10 . The food composition according to  claim 8 , wherein the longitudinal bone growth is an increase in the length of the tibia. 
     
     
         11 . The food composition according to  claim 8 , wherein the longitudinal bone growth is an increase in the activity of the growth plate. 
     
     
         12 . A functional beverage composition comprising an indirubin derivative for improving longitudinal bone growth. 
     
     
         13 . The functional beverage composition according to  claim 12 , wherein the indirubin derivative is indirubin-3′-oxime. 
     
     
         14 . The functional beverage composition according to  claim 12 , wherein the longitudinal bone growth is an increase in the length of the tibia. 
     
     
         15 . The functional beverage composition according to  claim 12 , wherein the longitudinal bone growth is an increase in the activity of the growth plate.

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