Method for non-toxic treatment for drug withdrawal

Abstract

The disclosure provides a method to administer noribogaine to a human patient having drug addiction in dosages that provide efficacy without leading to any significant deleterious clinical signs.

What is claimed is: 
     
         1 . A method for treating withdrawal symptoms in a patient suffering from withdrawal from addiction to a substance comprising administering to the patient a dosage of noribogaine that provides a C max  of noribogaine of less than about 1980 ng/mg serum and an average AUC/24 hr of about 1,100 ng/ml. 
     
     
         2 . A method for treating withdrawal symptoms in a patient suffering from withdrawal from addiction to a substance comprising administering to the patient a dosage of noribogaine that provides a C max  of noribogaine of less than about 1800 ng/mg serum and an AUC/24 hr of about 1000 ng/ml. 
     
     
         3 . A method for treating withdrawal symptoms in a patient suffering from withdrawal from addiction to a substance comprising administering to the patient a dosage of noribogaine that provides a C max  of noribogaine of less than about 1620 ng/mg serum and an AUC/24 hr of about 900 ng/ml. 
     
     
         4 . A method for treating withdrawal symptoms in a patient suffering from withdrawal from addiction to a substance comprising administering to the patient a dosage of noribogaine that provides a C max  of noribogaine of less than about 1440 ng/mg serum and an AUC/24 hr of about 800 ng/ml. 
     
     
         5 . A method for treating withdrawal symptoms in a patient suffering from withdrawal from addiction to a substance comprising administering to the patient a dosage of noribogaine that provides a C max  of noribogaine of less than about 1260 ng/mg serum and an AUC/24 hr of about 700 ng/ml. 
     
     
         6 . A method for treating withdrawal symptoms in a patient suffering from withdrawal from addiction to a substance comprising administering to the patient a dosage of noribogaine that provides a C max  of noribogaine of less than about 1400 ng/mg scrum and an AUC/24 hr of from about 600 ng/ml. 
     
     
         7 . A method for treating withdrawal symptoms in a patient suffering from withdrawal from addiction to a substance comprising administering to the patient a dosage of noribogaine that provides a C max  of noribogaine of less than about 900 ng/mg serum and an AUC/24 hr of about 500 ng/ml. 
     
     
         8 . A method for treating withdrawal symptoms in a patient suffering from withdrawal from addiction to a substance comprising administering to the patient a dosage of noribogaine that provides a C max  of noribogaine of less than about 720 ng/mg serum and an AUC/24 hr of about 400 ng/ml. 
     
     
         9 . A method for treating withdrawal symptoms in a patient suffering from withdrawal from addiction to a substance comprising administering to the patient a dosage of noribogaine that provides a C max  of noribogaine of less than about 540 ng/mg serum and an AUC/24 hr of about 300 ng/ml. 
     
     
         10 . A method for treating withdrawal symptoms in a patient suffering from withdrawal from addiction to a substance comprising administering to the patient a dosage of noribogaine that provides a C max  of noribogaine of less than about 360 ng/mg serum and an AUC/24 hr of about 200 ng/ml. 
     
     
         11 . A method for treating withdrawal symptoms in a patient suffering from withdrawal from addiction to a substance comprising administering to the patient a dosage of noribogaine that provides a C max  of noribogaine of less than about 180 ng/mg serum and an AUC/24 hr of about 100 ng/ml. 
     
     
         12 . A method for treating withdrawal symptoms in a patient suffering from withdrawal from addiction to a substance comprising administering to the patient a dosage of noribogaine from about 100 mg to about 600 mg at intervals of about 24 hours. 
     
     
         13 . The method according to  claim 12 , wherein the patient is administered a dosage of noribogaine from about 100 mg to about 500 mg at intervals of about 24 hours. 
     
     
         14 . The method according to  claim 12 , wherein the patient is administered a dosage of noribogaine from about 100 mg to about 400 mg at intervals of about 24 hours. 
     
     
         15 . The method according to  claim 12 , wherein the patient is administered a dosage of noribogaine from about 100 mg to about 300 mg at intervals of about 24 hours. 
     
     
         16 . The method according to  claim 12 , wherein the patient is administered a dosage of noribogaine from about 100 mg to about 200 mg at intervals of about 24 hours. 
     
     
         17 . A method for treating withdrawal symptoms in a patient suffering from withdrawal from addiction to a substance comprising administering to the patient a dosage of noribogaine from about 200 mg to about 600 mg at intervals of about 24 hours. 
     
     
         18 . The method according to  claim 17 , wherein the patient is administered a dosage of noribogaine from about 200 mg to about 500 mg at intervals of about 24 hours. 
     
     
         19 . The method according to  claim 17 , wherein the patient is administered a dosage of noribogaine from about 200 mg to about 400 mg at intervals of about 24 hours. 
     
     
         20 . The method according to  claim 17 , wherein the patient is administered a dosage of noribogaine from about 200 mg to about 300 mg at intervals of about 24 hours. 
     
     
         21 . A method for treating withdrawal symptoms in a patient suffering from withdrawal from addiction to a substance comprising administering to the patient a dosage of noribogaine from about 300 mg to about 600 mg at intervals of about 24 hours. 
     
     
         22 . The method according to  claim 21 , wherein the patient is administered a dosage of noribogaine from about 300 mg to about 500 mg at intervals of about 24 hours. 
     
     
         23 . The method according to  claim 21 , wherein the patient is administered a dosage of noribogaine from about 300 mg to about 400 mg at intervals of about 24 hours. In some embodiments each patient is administered from about 400 mg to about 500 mg at intervals of about 24 hours. 
     
     
         24 . A method for treating withdrawal symptoms in a patient suffering from withdrawal from addiction to a substance comprising administering to the patient a dosage of noribogaine from about 500 mg to about 600 mg at intervals of about 24 hours.