Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide f2 alpha agonists

Abstract

The present invention is directed to compositions and methods for the treatment of post-chemotherapeutic hypotrichosis. More specifically, the present invention is directed to the use of compositions comprising bimatoprost for the treatment of post-chemotherapeutic hypotrichosis which may be applied before, during and after receiving chemotherapeutic treatment.

What is claimed is: 
     
         1 ) A method of growing eyelashes in chemotherapy patients, the method comprising applying 0.03% w/v bimatoprost at least once a day to the eyelids of a chemotherapy patient from at least one selected from the group consisting of before, during, and after chemotherapeutic treatment wherein patients receiving 0.03% w/v bimatoprost resulted in greater eyelash growth as compared to patients not receiving 0.03% w/v bimatoprost. 
     
     
         2 ) The method of  claim 1 , wherein 0.03% w/v bimatoprost is applied after chemotherapeutic treatment and results in greater eyelash growth in patients as compared to patients not receiving 0.03% w/v bimatoprost. 
     
     
         3 ) The method of  claim 2 , wherein the method results in eyelashes which are longer or thicker as compared to patients not receiving 0.03% w/v bimatoprost. 
     
     
         4 ) The method of  claim 1 , wherein the patients receiving 0.03% w/v bimatoprost before starting chemotherapeutic treatment resulted in greater eyelash growth as compared to patients receiving 0.03% w/v bimatoprost during or after chemotherapeutic treatment. 
     
     
         5 ) The method of  claim 1 , wherein 0.03% w/v bimatoprost is applied to the upper eyelid. 
     
     
         6 ) The method of  claim 1 , wherein 0.03% w/v bimatoprost is applied to the lower eyelid. 
     
     
         7 ) The method of  claim 1 , wherein the bimatoprost is added before, during and after chemotherapeutic treatment. 
     
     
         8 ) A method of treating eyelashes loss in chemotherapy patients, the method comprising applying 0.03% w/v bimatoprost at least once a day to the eyelids of a chemotherapy patient from at least one selected from the group consisting of before, during, and after chemotherapeutic treatment wherein patients receiving 0.03% w/v bimatoprost resulted in greater eyelash growth as compared to patients not receiving 0.03% w/v bimatoprost. 
     
     
         9 ) The method of  claim 8 , wherein 0.03% w/v bimatoprost is applied after chemotherapeutic treatment and results in greater eyelash growth in patients as compared to patients not receiving 0.03% w/v bimatoprost. 
     
     
         10 ) The method of  claim 9 , wherein the method results in eyelashes which are longer or thicker as compared to patients not receiving 0.03% w/v bimatoprost. 
     
     
         11 ) The method of  claim 8 , wherein the patients receiving 0.03% w/v bimatoprost before starting chemotherapeutic treatment resulted in greater eyelash growth as compared to patients receiving 0.03% w/v bimatoprost during or after chemotherapeutic treatment. 
     
     
         12 ) The method of  claim 8 , wherein 0.03% w/v bimatoprost is applied to the upper eyelid. 
     
     
         13 ) The method of  claim 8 , wherein 0.03% w/v bimatoprost is applied to the lower eyelid. 
     
     
         14 ) The method of  claim 8 , wherein the bimatoprost is applied after completing chemotherapeutic treatment. 
     
     
         15 ) The method of  claim 14 , wherein the method is applied for at least 12 months after completing chemotherapeutic treatment. 
     
     
         16 ) The method of  claim 12  wherein the method is applied prior to receiving chemotherapeutic treatment. 
     
     
         17 ) The method of  claim 16 , wherein the method is applied for six months after receiving chemotherapeutic treatment. 
     
     
         18 ) The method of  claim 8  wherein the bimatoprost is in the form of a solution or an emulsion. 
     
     
         19 ) The method of  claim 8  wherein the bimatoprost is applied to the upper eyelid or both the upper and lower eyelid. 
     
     
         20 ) The method of  claim 8  wherein the method is applied after the patient completes chemotherapeutic treatment.