Bacterial anti-phage defense systems

Abstract

An isolated polypeptide is disclosed comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 2773-5544 and 11089-11094, wherein the polypeptide has antimicrobial activity. Uses thereof for treating microbial infections are also disclosed.

What is claimed is: 
     
         1 . A method of killing a microbe, the method comprising contacting the microbe with an isolated peptide comprising an amino acid sequence of a toxin having a domain selected from the group consisting of COG0514, DUF1814, COG2189, PF09019, DUF1814, DUF324 and PF07916, thereby killing the microbe. 
     
     
         2 . The method of  claim 1 , wherein when said peptide comprises said COG0514 domain said peptide is selected from the group consisting of SEQ ID NO: 2872-2935. 
     
     
         3 . The method of  claim 1 , wherein when said peptide comprises said DUF1814 domain said peptide is selected from the group consisting of SEQ ID NO: 2773-2804, 3031-3078. 
     
     
         4 . The method of  claim 1 , wherein when said peptide comprises said COG2189 domain said peptide is selected from the group consisting of SEQ ID NO: 3079-3087. 
     
     
         5 . The method of  claim 1 , wherein when said peptide comprises said PF09019 domain said peptide is selected from the group consisting of SEQ ID NO: 3088-3094. 
     
     
         6 . The method of  claim 1 , wherein when said peptide comprises said DUF324 domain said peptide is selected from the group consisting of SEQ ID NO: 3110-3117. 
     
     
         7 . The method of  claim 1 , wherein when said peptide comprises said PF07916 domain said peptide is selected from the group consisting of SEQ ID NO: 3095-3109.