Indazolones as modulators of tnf signaling

Abstract

The disclosure provides indazolone compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the disclosure may be useful for treating immunological and oncological conditions.

1 . A compound of Formula (I), 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt, prodrug or stereoisomer thereof, wherein
 X, Y and Z are independently CR 4  or N;
 provided that Y and Z are not both N; 
 
 L is a bond, optionally substituted (C 1 -C 3 )alkylene or —C(O)—; 
 R 1  is H, CD 3 , optionally substituted (C 1 -C 3 )alkyl, or optionally substituted (C 3 -C 6 )cycloalkyl; 
 R 2  is optionally substituted aryl or optionally substituted heteroaryl; 
 R 3  is —R 3a -R 3b , wherein:
 R 3a  is an optionally substituted saturated, unsaturated or partially saturated heterocyclyl or optionally substituted heteroaryl; 
 R 3b  is —N(R a )(R b ), —O(R a ), optionally substituted (C 1 -C 5 )alkyl, optionally substituted (C 3 -C 6 )cycloalkyl, or —(CH 2 ) p -optionally substituted heterocyclyl; wherein
 R a  and R b  are independently selected from H, optionally substituted (C 1 -C 5 )alkyl, and —(CH 2 ) n -optionally substituted heterocyclyl; 
 
 
 R 4  is independently H, Cl, CN, F, CF 3 , or optionally substituted (C 1 -C 3 )alkyl; and 
 n is 0 or 1; 
 p is 0, 1 or 2. 
 
       
     
     
         2 . The compound according to  claim 1  wherein the compound is a compound of Formula (Ia), Formula (Ib), Formula (Ic), Formula (Id), or Formula (Ie) 
       
         
           
           
               
               
           
         
       
     
     
         3 . The compound according to  claim 1  wherein R 1  is optionally substituted (C 1 -C 3 )alkyl or optionally substituted cyclopropyl. 
     
     
         4 . The compound according to  claim 1  wherein R 2  is optionally substituted heteroaryl, or optionally substituted phenyl. 
     
     
         5 . The compound according to  claim 1  wherein R 3a  is optionally substituted 1,2,4-oxadiazolyl, optionally substituted pyrazolyl, optionally substituted pyridinyl, optionally substituted pyrimidinyl, optionally substituted pyrazinyl, or optionally substituted 1,2,4-thiadiazolyl. 
     
     
         6 . The compound according to  claim 1  wherein R 3b  is —N(R a )(R b ), —O(R a ), optionally substituted (C 1 -C 3 )alkyl, —(CH 2 ) p -optionally substituted 2-oxa-6-azaspiro[3.3]heptanyl, —(CH 2 ) p -optionally substituted 2-azaspiro[3.3]heptanyl, —(CH 2 ) p -optionally substituted 5-azaspiro[2.3]hexanyl, —(CH 2 ) p -optionally substituted azetidinyl, —(CH 2 ) p -optionally substituted morpholinyl, —(CH 2 ) p -optionally substituted oxetanyl, —(CH 2 ) p -optionally substituted piperazinyl, —(CH 2 ) p -optionally substituted piperidinyl, —(CH 2 ) p -optionally substituted pyrrolidinyl, —(CH 2 ) p -optionally substituted tetrahydropyranyl, —(CH 2 ) p -optionally substituted 6-oxohexahydropyrrolo[1,2-a]pyrazinyl, —(CH 2 ) p -optionally substituted tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one or —(CH 2 ) p -optionally substituted hexahydroimidazo[1,5-a]pyrazin-3(2H)-one;
 wherein R a  and R b  are independently selected from H, optionally substituted (C 1 -C 3 )alkyl, —(CH 2 ) n -oxoazepanyl, —(CH 2 ) n -optionally substituted tetrahydrofuranyl, —(CH 2 ) n -optionally substituted oxetanyl, —(CH 2 ) n -optionally substituted tetrahydropyranyl, and —(CH 2 ) n -optionally substituted pyrrolidinyl. 
 
     
     
         7 . The compound according to  claim 1  wherein L is a bond or optionally substituted (C 1 -C 2 )alkylene. 
     
     
         8 . The compound according to  claim 1  wherein R 2  is phenyl, pyridinyl or pyrimidinyl, and R 2  is optionally substituted by one or more substituents independently selected from halogen, CN, haloalkoxy, CF 3 , or optionally substituted (C 1 -C 3 )alkyl. 
     
     
         9 . The compound according to  claim 1  wherein R 3b  is —N(H)CH 2 -optionally substituted pyrrolidinyl, —O(R a ), —N(H)-optionally substituted oxetanyl, optionally substituted (C 1 -C 3 )alkyl, optionally substituted 2-oxa-6-azaspiro[3.3]heptanyl, optionally substituted 5-azaspiro[2.3]hexanyl, optionally substituted azetidinyl, optionally substituted morpholinyl, —(CH 2 ) p -optionally substituted oxetanyl, optionally substituted piperazinyl, optionally substituted piperidinyl, —(CH 2 ) p -optionally substituted pyrrolidinyl, or optionally substituted tetrahydropyranyl;
 wherein R a  is selected from H, optionally substituted (C 1 -C 3 )alkyl, —(CH 2 ) n -oxoazepanyl, —(CH 2 ) n -optionally substituted tetrahydrofuranyl, —(CH 2 ) n -optionally substituted oxetanyl, —(CH 2 ) n -optionally substituted tetrahydropyranyl, and —(CH 2 ) n -optionally substituted pyrrolidinyl. 
 
     
     
         10 . The compound according to  claim 1  wherein R 3b  is optionally substituted by one or more substituents independently selected from halogen, CN, —C(O)OH, —C(O)CH 3 , —C(O)NH 2 , NH 2 , ═O, —OH, optionally substituted (C 1 -C 3 )alkyl, optionally substituted (C 1 -C 3 )alkoxy and optionally substituted oxetanyl. 
     
     
         11 . The compound according to  claim 1  wherein Y is CR 4 . 
     
     
         12 . The compound according to  claim 1  wherein Z is CR 4 . 
     
     
         13 . The compound according to  claim 1  wherein the compound is:
 1-(2-(difluoromethoxy)benzyl)-2-methyl-6-(2-(((1-methyl-5-oxopyrrolidin-3-yl)methyl)amino)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 (R)-1-(5-(1-(2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)pyrrolidine-3-carboxylic acid; 
 (S)-1-(5-(1-(2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)pyrrolidine-3-carboxylic acid; 
 1-(4-chloropyridin-3-yl)methyl)-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 (R)-1-(2-(difluoromethoxy)benzyl)-6-(2-(3-hydroxypyrrolidin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 2-(5-(1-(2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)-2-azaspiro[3.3]heptane-6-carboxylic acid; 
 5-(5-(1-(2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)-5-azaspiro[2.3]hexane-1-carboxylic acid; 
 1-(2-(difluoromethoxy)benzyl)-2-ethyl-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-fluorobenzyl)-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 6-(2-(2-oxa-6-azaspiro[3.3]heptan-6-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)benzyl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(5-(1-(2-(difluoromethoxy)benzyl)-2,5-dimethyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)piperidine-4-carboxylic acid; 
 1-(2-(difluoromethoxy)benzyl)-2,5-dimethyl-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-2,5-dimethyl-6-(2-(3-oxopiperazin-1-yl)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-((3,6-dichloropyridin-2-yl)methyl)-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 6-(2-((1-acetylpyrrolidin-3-yl)amino)pyrimidin-5-yl)-1-(2-(difluoromethoxy)benzyl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(5-(1-(2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)azetidine-3-carboxylic acid; 
 1-(2-(difluoromethoxy)benzyl)-6-(2-(2,2-dimethylmorpholino)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-6-(2-(3-(hydroxymethyl)azetidin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-6-(2-(3-hydroxyazetidin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(5-(1-(2,5-dichlorobenzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)piperidine-4-carboxylic acid; 
 6-(5-chloro-2-morpholinopyridin-4-yl)-1-(2-(difluoromethoxy)benzyl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-2-methyl-6-(2-(oxetan-3-ylamino)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-benzoyl-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 6-(5-chloro-2-morpholinopyridin-4-yl)-1-(3-fluorobenzyl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzoyl)-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-6-(2-((2-hydroxyethyl)amino)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 2-(1-(5-(1-(2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)azetidin-3-yl)acetic acid; 
 1-(2-(difluoromethoxy)benzyl)-2-methyl-6-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-2-methyl-6-(2-morpholinopyridin-4-yl)-1H-indazol-3(2H)-one; 
 1-(3-fluorobenzyl)-2-methyl-6-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-1H-indazol-3(2H)-one; 
 1-(3-fluorobenzyl)-2-methyl-6-(2-morpholinopyridin-4-yl)-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-6-fluorobenzyl)-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(1-(2-(difluoromethoxy)phenyl)ethyl)-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 2-methyl-6-(2-morpholinopyrimidin-5-yl)-1-phenethyl-1H-indazol-3(2H)-one; 
 2-methyl-1-(2-methylbenzyl)-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(2,6-dichlorobenzyl)-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(3-(difluoromethoxy)benzyl)-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(3-fluorobenzyl)-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(2-fluorophenethyl)-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(2-fluorobenzyl)-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 2-((2-methyl-6-(2-morpholinopyrimidin-5-yl)-3-oxo-2,3-dihydro-1H-indazol-1-yl)methyl)benzonitrile; 
 2-methyl-1-(3-methylbenzyl)-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(4-fluorobenzyl)-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-benzyl-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(2,6-dichlorobenzyl)-2-methyl-6-(2-(3-oxopiperazin-1-yl)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(5-(1-(2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)piperidine-4-carboxylic acid; 
 1-(2-(difluoromethoxy)benzyl)-6-(2-methoxypyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-2-methyl-6-(2-(3-oxopiperazin-1-yl)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(2,5-dichlorobenzyl)-2-methyl-6-(2-(piperazin-1-yl)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(2,5-dichlorobenzyl)-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-2-methyl-6-(6-(3-oxopiperazin-1-yl)pyridin-3-yl)-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-2-methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-2-methyl-6-(6-morpholinopyridin-3-yl)-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-2-methyl-6-(2-(3-(oxetan-3-yl)azetidin-1-yl)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 2-((5-(1-(2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)amino)propanamide; 
 1-(2-(difluoromethoxy)benzyl)-2-methyl-6-(5-morpholinopyrazin-2-yl)-1H-indazol-3(2H)-one; 
 1-((5-(1-(2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)methyl)azetidine-3-carboxylic acid; 
 1-(2-(difluoromethoxy)benzyl)-2-methyl-6-(2-(((5-oxopyrrolidin-3-yl)methyl)amino)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-((3-chloropyridin-2-yl)methyl)-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 2-cyclopropyl-1-(2-(difluoromethoxy)benzyl)-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(2,5-dichlorophenyl)-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-6-fluorobenzyl)-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 4-(5-(1-(2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)piperazine-1-carboxamide; 
 1-(1-(2-(difluoromethoxy)phenyl)ethyl)-6-(2-((R)-2-(methoxymethyl)pyrrolidin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 6-(2-(4-acetylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)benzyl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-2-methyl-6-(2-((2-oxoazepan-3-yl)amino)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(3-(difluoromethoxy)benzyl)-2-methyl-6-(2-((tetrahydrofuran-3-yl)amino)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-2-methyl-6-(2-((tetrahydro-2H-pyran-3-yl)amino)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-6-(2-((3-methoxypropyl)amino)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2,5-dichlorobenzyl)-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(5-(1-(2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrazin-2-yl)piperidine-4-carboxylic acid; 
 1-(2-(difluoromethoxy)benzyl)-2-methyl-6-(5-morpholino-1,2,4-thiadiazol-3-yl)-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-pyrazolo[4,3-b]pyridin-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-2-methyl-6-(2-((3-methyloxetan-3-yl)methyl)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-2-methyl-6-(3-morpholino-1,2,4-oxadiazol-5-yl)-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-pyrazolo[3,4-b]pyridin-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-pyrazolo[3,4-b]pyridin-3(2H)-one. 
 1-(2-(difluoromethoxy)benzyl)-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-pyrazolo[4,3-c]pyridin-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-2-methyl-6-(2-(6-oxohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 (R)-1-(2-(difluoromethoxy)benzyl)-2-methyl-6-(2-((tetrahydrofuran-3-yl)amino)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 (R)-7-(5-(1-(2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one; 
 (S)-7-(5-(1-(2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one; 
 7-(5-(1-(2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)hexahydroimidazo[1,5-a]pyrazin-3(2H)-one; 
 (R)-7-(5-(1-(2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)hexahydroimidazo[1,5-a]pyrazin-3(2H)-one; 
 (S)-7-(5-(1-(2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)hexahydroimidazo[1,5-a]pyrazin-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-(hydroxymethyl)benzyl)-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 (R)-7-(5-(1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)hexahydroimidazo[1,5-a]pyrazin-3(2H)-one; 
 (S)-7-(5-(1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)hexahydroimidazo[1,5-a]pyrazin-3(2H)-one; 
 (S)-7-(5-(1-(2-(Difluoromethoxy)-5-(hydroxymethyl)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)hexahydroimidazo[1,5-a]pyrazin-3(2H)-one; or 
 7-(5-(1-(2-(difluoromethoxy)-5-(hydroxymethyl)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-methylbenzyl)-5-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; or 
 (R)-1-(2-(difluoromethoxy)benzyl)-6-(2-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one. 
 
     
     
         14 . A compound of Formula (I), or a pharmaceutically acceptable salt, prodrug or stereoisomer thereof, wherein
 X, Y and Z are independently CR 4  or N;
 provided that Y and Z are not both N; 
   L is a bond, optionally substituted (C 1 -C 3 )alkylene or —C(O)—;   R 1  is H, CD 3 , CN, optionally substituted (C 1 -C 3 )alkyl, —(CH 2 ) n -optionally substituted phenyl, —(CH 2 ) n -optionally substituted heteroaryl or —(CH 2 ) n -optionally substituted heterocyclyl;   R 2  is optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl or optionally substituted cycloalkyl;   R 3  is —R 3a -R 3b , wherein:
 R 3a  is an optionally substituted saturated, unsaturated or partially saturated heterocyclyl or optionally substituted heteroaryl; 
 R 3b  is —N(R a )(R b ), —O(R a ), optionally substituted (C 1 -C 5 )alkyl, optionally substituted (C 3 -C 6 )cycloalkyl, or —(CH 2 ) p -optionally substituted heterocyclyl; wherein
 R a  and R b  are independently selected from H, optionally substituted (C 1 -C 5 )alkyl, and —(CH 2 ) n -optionally substituted heterocyclyl; 
 
   R 4  is independently H, Cl, CN, F, CF 3 , optionally substituted (C 1 -C 3 )alkyl or optionally substituted (C 1 -C 3 ) alkoxy; and   n is 0 or 1;   p is 0, 1 or 2.   
     
     
         15 . The compound according to  claim 14  wherein R 1  is H, CD 3 , optionally substituted (C 1 -C 3 )alkyl or —CH 2 -pyrimidinyl. 
     
     
         16 . The compound according to  claim 14  wherein R 2  is optionally substituted heteroaryl, optionally substituted heterocyclyl or optionally substituted phenyl. 
     
     
         17 . The compound according to  claim 14  wherein R 3a  is optionally substituted dihydropyranyl, optionally substituted imidazo[1,2-b]pyridazinyl, optionally substituted 1,2,4-oxadiazolyl, optionally substituted pyrazolyl, optionally substituted 3,6-dihydro-2H-pyranyl, optionally substituted pyridinyl, optionally substituted pyrimidinyl, optionally substituted pyrazinyl, or optionally substituted 1,2,4-thiadiazolyl. 
     
     
         18 . The compound according to  claim 14  wherein R 3b  is —N(R a )(R b ), —O(R a ), optionally substituted (C 1 -C 3 )alkyl, —(CH 2 ) p -optionally substituted imidazo[1,2-b]pyridazinyl, —(CH 2 ) p -optionally substituted morpholinyl, —(CH 2 ) p -optionally substituted piperazinyl, —(CH 2 ) p -optionally substituted piperidinyl, —(CH 2 ) p -optionally substituted pyrrolidinyl, —(CH 2 ) p -optionally substituted tetrahydropyranyl, —(CH 2 ) p -optionally substituted tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one, —(CH 2 ) p -optionally substituted hydroimidazo[1,2-b]pyridazin-3(2H)-one; or —(CH 2 ) p -optionally substituted hexahydroimidazo[1,5-a]pyrazin-3(2H)-one;
 wherein R a  and R b  are independently selected from H, optionally substituted (C 1 -C 3 )alkyl, —(CH 2 ) n -morpholinyl —(CH 2 ) n -oxoazepanyl, —(CH 2 ) n -optionally substituted tetrahydrofuranyl, —(CH 2 ) n -optionally substituted oxetanyl, —(CH 2 ) n -optionally substituted piperidinyl, —(CH 2 ) n -optionally substituted tetrahydropyranyl, —(CH 2 ) p -optionally substituted hexahydroimidazo[1,5-a]pyrazin-3(2H)-one, and —(CH 2 ) n -optionally substituted pyrrolidinyl. 
 
     
     
         19 . The compound according to  claim 14  wherein L is a bond or optionally substituted (C 1 -C 2 )alkylene. 
     
     
         20 . The compound according to  claim 14  wherein R 2  is 4,5-dihydrobenzo[f][1,5]thiazepin-3(2h)-one, 1.3-dihydroisobenzofuranyl, phenyl, pyridinyl, pyrimidinyl or pyrrolyl, and R 2  is optionally substituted by one or more substituents independently selected from halogen, CN, haloalkoxy, CF 3 , —SCHF 2 , optionally substituted (C 1 -C 3 )alkyl, optionally substituted (C 3 -C 6 )cycloalkyl, —CH 2 OC(O)C(H)NH 2 CH 3 , —CH 2 NHC(O)OCH 3 , —CH 2 -pyridinyl, —CH 2 -pyrrolyl, —CH 2 -optionally substituted pyrazolyl, —CH 2 -triazolyl-, —CH 2 —O-pyrazolyl, —C(O)CH 3 , —N(H)CH 2 C(OH)(CH 3 ) 2 , —N(H)CH 2 C(H)(OH)CH 3 , or —N(H)(R c );
 wherein R c  is —(CH 2 ) n -optionally substituted heterocyclyl or —(CH 2 ) n  optionally substituted heteroaryl, wherein n is 0 or 1. 
 
     
     
         21 . The compound according to  claim 14  wherein R 3b  is —N(H)-optionally substituted oxetanyl, —N(H)-optionally substituted piperidin-2-one, —N(H)-optionally substituted tetrahydropyranyl, —O-tetrahydropyranyl, optionally substituted (C 1 -C 3 )alkyl, optionally substituted morpholinyl, optionally substituted piperazinyl, optionally substituted piperidinyl, optionally substituted pyrrolidinyl, -optionally substituted tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one —(CH 2 ) p -optionally substituted hexahydroimidazo[1,5-a]pyrazin-3(2H)-one, or optionally substituted tetrahydropyranyl. 
     
     
         22 . The compound according to  claim 14  wherein R 3b  is optionally substituted by one or more substituents independently selected from halogen, —CHO, CN, —C(O)OH, —C(O)CH 3 , —C(O)CH 2 CN, —C(O)CH 2 OH, —C(O)CH 2 NH 2 , C(O)CH 2 OCH 3 , —C(O)C(H)(CH 3 )NH 2 , —C(O)C(H)(OH)CH 2 OH, —C(O)C(H)(OH)CH 2 C(O)OH, —C(O)C(H)(OH)CH 2 NH 2 , —C(O)CH 2 OC(O)C(H)(NH 2 )CH(CH 3 ) 2 , —C(O)NH 2 , —C(O)OCH 3 , —C(O)CH 2 OP(O)(OH) 2 , —C(O)— oxetanyl, NH 2 , ═O, —OH, —S(O) 2 CH 3 , optionally substituted (C 1 -C 3 )alkyl, optionally substituted (C 1 -C 3 )alkoxy and optionally substituted oxetanyl. 
     
     
         23 . The compound according to  claim 14  wherein Y is CR 4  and R 4  is H. 
     
     
         24 . The compound according to  claim 14  wherein Z is CR 4  and R 4  is H or F. 
     
     
         25 . The compound according to  claim 14  wherein the compound is
 (R)-1-(5-((1H-pyrazol-4-yl)methyl)-2-(difluoromethoxy)benzyl)-6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-1-(2-(difluoromethoxy)benzyl)-7-fluoro-6-(2-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-2-(4-(difluoromethoxy)-3-((6-(2-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-1-yl)methyl)phenyl)acetonitrile; 
 (R)-2-(4-(5-(1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)-2-methylpiperazin-1-yl)-2-oxoethyl dihydrogen phosphate;) 
 (R)-1-(2-(difluoromethoxy)benzyl)-5,7-difluoro-6-(2-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-1-(2-chlorobenzyl)-7-fluoro-6-(2-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-1-(2-chlorobenzyl)-7-fluoro-6-(2-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-1-(2-(difluoromethoxy)-5-methylbenzyl)-5-fluoro-6-(2-(4-(2-hydroxyacetyl)-2-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(5-((1H-pyrazol-5-yl)methyl)-2-(difluoromethoxy)benzyl)-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-methylbenzyl)-6-(3-(2-hydroxypropan-2-yl)imidazo[1,2-b]pyridazin-7-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-6-(2-(3-methylpyrrolidin-3-yl)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(1-(2,5-difluorophenyl)ethyl)-6-(2-((R)-4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-methylbenzyl)-5-fluoro-6-(6-(1-hydroxyethyl)-5,6-dihydro-2H-pyran-3-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-chloro-5-((2-hydroxy-2-methylpropyl)amino)benzyl)-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-methylbenzyl)-6-(2-(1,3-dimethylpyrrolidin-3-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one acetate; 
 1-(2-(difluoromethoxy)-5-methylbenzyl)-6-(2-(1,3-dimethylpyrrolidin-3-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-1-(2-(difluoromethoxy)benzyl)-5-fluoro-6-(2-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 6-[2-[(3R)-4-acetyl-3-methyl-piperazin-1-yl]pyrimidin-5-yl]-1-[[2-(difluoromethoxy)-5-methyl-phenyl]methyl]-2(trideuteriomethyl)indazol-3-one; 
 (S)-6-(2-(4-acetyl-2-methylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-1-(2-(difluoromethoxy)-5-methylbenzyl)-6-(2-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-[[2-(difluoromethoxy)-5-methyl-phenyl]methyl]-6-[2-[(3R)-4-(2-hydroxyacetyl)-3-methyl-piperazin-1-yl]pyrimidin-5-yl]-2-(trideuteriomethyl)indazol-3-one; 
 (R)-1-(2-(difluoromethoxy)-5-methylbenzyl)-6-(2-(4-(2-hydroxyacetyl)-2-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-6-(2-(4-acetyl-2-methylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)-6-(hydroxymethyl)benzyl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-1-(2-(difluoromethoxy)benzyl)-6-(2-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)-4-methylpyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-methylbenzyl)-5-fluoro-6-(6-(2-hydroxypropan-2-yl)-5,6-dihydro-2H-pyran-3-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-((S)-1-(2,6-difluorophenyl)ethyl)-6-(2-((R)-4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-6-(2-(3-methyl-4-(methylsulfonyl)piperazin-1-yl)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 (R)-methyl 4-(5-(1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)-2-methylpiperazine-1-carboxylate; 
 (R)-6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)-6-(hydroxymethyl)benzyl)-2-methyl-1H-indazol-3(2H)-one; 
 (S)-7-(5-(1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one; 
 (R)-6-(2-(4-acetyl-2-methylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-1-(2-(difluoromethoxy)benzyl)-6-(2-(4-(2-hydroxyacetyl)-2-methylpiperazin-1-yl)-4-methylpyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-7-(5-(1-(5-((1H-1,2,4-triazol-1-yl)methyl)-2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)hexahydroimidazo[1,5-a]pyrazin-3(2H)-one; 
 (R)-7-(5-(1-(2-(difluoromethoxy)-6-(hydroxymethyl)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)hexahydroimidazo[1,5-a]pyrazin-3(2H)-one; 
 1-(5-((1H-pyrazol-4-yl)methyl)-2-(difluoromethoxy)benzyl)-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-((difluoromethyl)thio)-5-methylbenzyl)-2-methyl-1H-pyrazolo[3,4-b]pyridin-3(2H)-one; 
 (R)-2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-chloro-5-methylbenzyl)-2-methyl-1H-pyrazolo[3,4-b]pyridin-3(2H)-one; 
 (R)-6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-((difluoromethyl)thio)-5-methylbenzyl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-2-(4-(difluoromethoxy)-3-((2-methyl-3-oxo-6-(2-(3-oxotetrahydro-1H-oxazolo[3,4-a]pyrazin-7(3H)-yl)pyrimidin-5-yl)-2,3-dihydro-1H-indazol-1-yl)methyl)phenyl)acetonitrile; 
 (S)-1-(2-(difluoromethoxy)benzyl)-6-(2-(4-(2-hydroxyacetyl)-2-methylpiperazin-1-yl)-4-methylpyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-6-(2-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1-((6-methyl-3-(trifluoromethyl)pyridin-2-yl)methyl)-1H-indazol-3(2H)-one; 
 (R)-7-(5-(1-(2-(difluoromethoxy)-6-(methoxymethyl)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)hexahydroimidazo[1,5-a]pyrazin-3(2H)-one; 
 (S)-1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-6-(2-(3-methyl-4-(methylsulfonyl)piperazin-1-yl)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 (R)-1-(2-(difluoromethoxy)benzyl)-5-fluoro-6-(2-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-pyrazolo[3,4-b]pyridin-3(2H)-one; 
 6-(2-((R)-4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1-((S)-1-(m-tolyl)ethyl)-1H-indazol-3(2H)-one; 
 6-(2-(4-(3-amino-2-hydroxypropanoyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-6-(2-((R)-4-((S)-2,3-dihydroxypropanoyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-1-(2-(difluoromethoxy)benzyl)-5-fluoro-6-(2-(4-(2-hydroxyacetyl)-2-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-6-(2-((3R)-3-methyl-4-(oxetane-2-carbonyl)piperazin-1-yl)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 (R)-2-(4-(5-(1-(2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)-2-methylpiperazin-1-yl)-2-oxoethyl phosphate; 
 (R)-1-(2-(difluoromethoxy)benzyl)-6-(2-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-3-(4-(5-(1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)-2-methylpiperazin-1-yl)-3-oxopropanenitrile; 
 1-(1-(2,6-difluorophenyl)ethyl)-6-(2-((R)-4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (S)-1-(2-(difluoromethoxy)benzyl)-6-(2-(4-(2-hydroxyacetyl)-2-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-6-(2-((R)-4-((R)-2,3-dihydroxypropanoyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-6-(2-(4-acetyl-2-ethylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-1-(2-(difluoromethoxy)-5-(hydroxymethyl)benzyl)-2-methyl-6-(2-((2-oxopiperidin-4-yl)amino)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 (S)-7-(5-(1-(2-(difluoromethoxy)-5-(hydroxymethyl)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one; 
 (R)-1-(2-(difluoromethoxy)benzyl)-5-fluoro-6-(6-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyridin-3-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-1-(2-chlorobenzyl)-6-(2-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-6-(2-(3-methyl-4-(oxetane-3-carbonyl)piperazin-1-yl)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 4-(5-(1-(2-(difluoromethoxy)-5-(hydroxymethyl)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)piperazine-1-carbaldehyde; 
 (S)-2-((R)-4-(5-(1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)-2-methylpiperazin-1-yl)-2-oxoethyl 2-amino-3-methylbutanoate; 
 (R)-7-(5-(1-(2-(difluoromethoxy)-5-(hydroxymethyl)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one; 
 (S)-7-(5-(1-(2-chloro-5-methylbenzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)hexahydroimidazo[1,5-a]pyrazin-3(2H)-one; 
 (R)-1-(2-(difluoromethoxy)benzyl)-7-fluoro-6-(2-(4-(2-hydroxyacetyl)-2-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1-((6-methyl-3-(trifluoromethyl)pyridin-2-yl)methyl)-1H-indazol-3(2H)-one; 
 (R)-7-(5-(1-(2-(Difluoromethoxy)-5-methylbenzyl)-2-(methyl-d 3 )-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)hexahydro-3H-oxazolo[3,4-a]pyrazin-3-one; 
 (R)-1-(2-(difluoromethoxy)-5-methylbenzyl)-6-(2-(4-(2-methoxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (S)-7-(5-(2-methyl-1-(5-methyl-2-(trifluoromethyl)benzyl)-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)hexahydroimidazo[1,5-a]pyrazin-3(2H)-one; 
 6-(2-(4-acetylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)-5-(hydroxymethyl)benzyl)-2-methyl-1H-indazol-3(2H)-one; 
 (S)-1-(2-(difluoromethoxy)-5-methylbenzyl)-6-(2-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 6-(2-((R)-4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1-(1-(m-tolyl)propyl)-1H-indazol-3(2H)-one; 
 (S)-7-(5-(1-(5-((4H-1,2,4-triazol-4-yl)methyl)-2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)hexahydroimidazo[1,5-a]pyrazin-3(2H)-one; 
 (R)-1-(2-(difluoromethoxy)benzyl)-6-(2-(4-(2-hydroxyacetyl)-2-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-1H-pyrazolo[3,4-b]pyridin-3(2H)-one; 
 (R)-7-(5-(1-(3-(difluoromethoxy)-6-(hydroxymethyl)pyridin-2-yl)methyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)hexahydroimidazo[1,5-a]pyrazin-3(2H)-one; 
 (R)-6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)benzyl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1-((6-methyl-3-(trifluoromethyl)pyridin-2-yl)methyl)-1H-pyrazolo[3,4-b]pyridin-3(2H)-one; 
 (S)-4-(difluoromethoxy)-3-((2-methyl-3-oxo-6-(2-((R)-3-oxohexahydroimidazo[1,5-a]pyrazin-7(1H)-yl)pyrimidin-5-yl)-2,3-dihydro-1H-indazol-1-yl)methyl)benzyl 2-aminopropanoate hydrochloride; 
 (R)-6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1-((4-(trifluoromethyl)-1H-pyrrol-3-yl)methyl)-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-methylbenzyl)-6-(2-(2-hydroxypropan-2-yl)-4-methylpyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 6-(2-((R)-4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1-(1-(m-tolyl)ethyl)-1H-indazol-3(2H)-one; 
 1-(2-chloro-5-((4,5,6,7-tetrahydro-1H-indazol-7-yl)amino)benzyl)-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-2-(4-(difluoromethoxy)-3-((2-methyl-3-oxo-6-(2-(3-oxohexahydroimidazo[1,5-a]pyrazin-7(1H)-yl)pyrimidin-5-yl)-2,3-dihydro-1H-indazol-1-yl)methyl)phenyl)acetonitrile; 
 (R)-6-(2-(4-(2-aminoacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-methylbenzyl)-6-(2-(4-(2-hydroxyacetyl)piperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-1-(5-(((1H-pyrazol-5-yl)oxy)methyl)-2-(difluoromethoxy)benzyl)-6-(2-(4-actyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (S)-6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(5-((1H-1,2,4-triazol-1-yl)methyl)-2-difluoromethoxy)benzyl)-5-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-7-(5-(1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one; 
 (R)-1-(2-(difluoromethoxy)-5-(hydroxymethyl)benzyl)-2-methyl-6-(2-((1-methyl-2-oxopiperidin-4-yl)amino)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 (R)-1-(2-(difluoromethoxy)benzyl)-6-(2-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-7-methoxy-2-methyl-1H-indazol-3(2H)-one; 
 1-((S)-1-(2-fluorophenyl)ethyl)-6-(2-((R)-4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-6-(2-(4-acetyl-2-methylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)benzyl)-2-methyl-1H-indazol-3(2H)-one; 
 6-(2-((R)-4-((S)-2-aminopropanoyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-methylbenzyl)-5-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-(hydroxymethyl)benzyl)-2-methyl-6-(2-((2-oxopiperidin-4-yl)amino)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 (R)-methyl 3-((6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-1-yl)methyl)-4-(difluoromethoxy)benzylcarbamate; 
 1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-6-(2-((tetrahydro-2H-pyran-4-yl)oxy)pyridin-4-yl)-1H-indazol-3(2H)-one; 
 (S)-3-(4-(5-(1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)-2-methylpiperazin-1-yl)-3-oxopropanenitrile; 
 (S)-2-((R)-4-(5-(1-(2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)-2-methylpiperazin-1-yl)-2-oxoethyl 2-amino-3-methylbutanoate; 
 (R)-7-(5-(1-(2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)-2-(2-hydroxyethyl)hexahydroimidazo[1,5-a]pyrazin-3(2H)-one; 
 (R)-6-(2-(4-(2-hydroxyacetyl)-2-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1-((6-methyl-3-(trifluoromethyl)pyridin-2-yl)methyl)-1H-indazol-3(2H)-one; 
 (R)-7-(5-(2-methyl-1-((6-methyl-3-(trifluoromethyl)pyridin-2-yl)methyl)-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one; 
 (R)-6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-1-((1-acetyl-4-(trifluoromethyl)-1H-pyrrol-3-yl)methyl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-1-(2-(difluoromethoxy)-5-methylbenzyl)-6-(3-(1-hydroxyethyl)imidazo[1,2-b]pyridazin-7-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-2-(6-((6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-1-yl)methyl)-5-(trifluoromethyl)pyridin-2-yl)acetonitrile; 
 (R)-1-(2-(difluoromethoxy)benzyl)-6-(2-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-3-oxo-2,3-dihydro-1H-indazole-7-carbonitrile; 
 1-(2-(difluoromethoxy)-5-methylbenzyl)-5-fluoro-6-(2-(2-hydroxypropan-2-yl)-4-methylpyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-4-((R)-4-(5-(1-(2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)-2-methylpiperazin-1-yl)-3-hydroxy-4-oxobutanoic acid; 
 1-(2-(difluoromethoxy)benzyl)-6-(2-((2R,4R)-4-hydroxy-2-methylpiperidin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-1-((1-((4-methoxy-1H-pyrazol-3-yl)methyl)-4-(trifluoromethyl)-1H-pyrrol-3-yl)methyl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-2-(4-(difluoromethoxy)-3-((6-(2-(4-(2-hydroxyacetyl)-2-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-1-yl)methyl)phenyl)acetonitrile; 
 (R)-2-(2-((6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-1-yl)methyl)-3-(difluoromethoxy)phenyl)acetonitrile; 
 (R)-2-((R)-4-(5-(1-(2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)-2-methylpiperazin-1-yl)-2-oxoethyl 2-amino-3-methylbutanoate; 
 1-(2-(difluoromethoxy)-5-(hydroxymethyl)benzyl)-2-methyl-6-(2-((1-methyl-2-oxopiperidin-4-yl)amino)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 6-(2-(4-acetylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2,5-dimethylbenzyl)-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 (R)-1-(2-(difluoromethoxy)benzyl)-6-(2-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2,7-dimethyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-(hydroxymethyl)benzyl)-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (S)-7-(5-(2-methyl-1-(6-methyl-3-(trifluoromethyl)pyridin-2-yl)methyl)-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)hexahydroimidazo[1,5-a]pyrazin-3(2H)-one; 
 (R)-6-(2-(4-acetyl-2-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1-((6-methyl-3-(trifluoromethyl)pyridin-2-yl)methyl)-1H-indazol-3(2H)-one; 
 6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1-((1-(pyridin-3-ylmethyl)-4-(trifluoromethyl)-1H-pyrrol-3-yl)methyl)-1H-indazol-3(2H)-one; 
 6-(2-(4-(3-amino-2-hydroxypropanoyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)benzyl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-methylbenzyl)-5-fluoro-6-(2-(1-hydroxy-2-methylpropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-1-(2-chloro-5-methylbenzyl)-6-(2-(4-(2-hydroxyacetyl)-2-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-pyrazolo[3,4-b]pyridin-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-methylbenzyl)-6-(3-(1-hydroxyethyl)imidazo[1,2-b]pyridazin-7-yl)-2-methyl-1H-indazol-3(2H)-one; 
 6-(2-(2-aminopropan-2-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-1H-indazol-3(2H)-one; 
 (1S,3S)-3-(4-fluoromethoxy)-3-((6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-1-yl)methyl)phenyl)cyclopentanecarbonitrile; 
 (S)-1-(2-(difluoromethoxy)-5-methylbenzyl)-6-(3-(1-hydroxyethyl)imidazo[1,2-b]pyridazin-7-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (S)-7-(5-(1-(5-chloro-2-(trifluoromethyl)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)hexahydroimidazo[1,5-a]pyrazin-3(2H)-one; 
 (R)-6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-1-((3-chloro-6-methylpyridin-2-yl)methyl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-7-(5-(1-(2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)-2-methylhexahydroimidazo[1,5-a]pyrazin-3(2H)-one; 
 (S)-7-(5-(2-methyl-1-((1-methyl-4-(trifluoromethyl)-1H-pyrrol-3-yl)methyl)-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)hexahydroimidazo[1,5-a]pyrazin-3(2H)-one; 
 (R)-1-(2-chlorobenzyl)-6-(2-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-pyrazolo[3,4-b]pyridin-3(2H)-one; 
 (S)-1-(2-(difluoromethoxy)-5-(hydroxymethyl)benzyl)-2-methyl-6-(2-((2-oxopiperidin-4-yl)amino)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-2-methyl-6-(2-((tetrahydro-2H-pyran-4-yl)oxy)pyridin-4-yl)-1H-indazol-3(2H)-one; 
 6-(2-((R)-4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1-(1-phenylethyl)-1H-indazol-3(2H)-one; 
 1-(1-(2-fluorophenyl)ethyl)-6-(2-((R)-4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-1-((3-(difluoromethoxy)-6-methylpyridin-2-yl)methyl)-6-(2-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-1-((1-(2-hydroxyethyl)-4-(trifluoromethyl)-1H-pyrrol-3-yl)methyl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(5-((1H-1,2,4-triazol-1-yl)methyl)-2-(difluoromethoxy)benzyl)-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-methylbenzyl)-6-(2-(4-hydroxypiperidin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-methylbenzyl)-6-(2-isopropylpyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-1-(2-chlorobenzyl)-6-(2-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2,7-dimethyl-1H-indazol-3(2H)-one; 
 6-(6-(2-aminopropan-2-yl)pyridin-3-yl)-1-(2-(difluoromethoxy)-5-methylbenzyl)-5-fluoro-2-methyl-1H-indazol-3(2H)-one; 
 (S)-4-(difluoromethoxy)-3-((2-methyl-3-oxo-6-(2-((S)-3-oxotetrahydro-1H-oxazolo[3,4-a]pyrazin-7(3H)-yl)pyrimidin-5-yl)-2,3-dihydro-1H-indazol-1-yl)methyl)benzyl 2-aminopropanoate; 
 1-(2-(difluoromethoxy)benzyl)-6-(2-((2R,4S)-4-hydroxy-2-methylpiperidin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-4-(difluoromethoxy)-3-((2-methyl-3-oxo-6-(2-(3-oxohexahydroimidazo[1,5-a]pyrazin-7(1H)-yl)pyrimidin-5-yl)-2,3-dihydro-1H-indazol-1-yl)methyl)benzyl dimethylcarbamate; 
 (S)-6-(2-(4-(2-aminoacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-7-(5-(1-((6-(hydroxymethyl)-3-(trifluoromethyl)pyridin-2-yl)methyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)hexahydroimidazo[1,5-a]pyrazin-3(2H)-one; 
 (S)-7-(5-(1-((5-chloro-1,3-dihydroisobenzofuran-4-yl)methyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)hexahydroimidazo[1,5-a]pyrazin-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-methylbenzyl)-7-fluoro-6-(2-(2-hydroxypropan-2-yl)-4-methylpyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-methylbenzyl)-5-fluoro-6-(2-(2-hydroxypropan-2-yl)-4-methylpyrimidin-5-yl)-2-methyl-1H-pyrazolo[3,4-b]pyridin-3(2H)-one; 
 1-(2-chloro-5-methylbenzyl)-6-(2-(2-hydroxypropan-2-yl)-4-methylpyrimidin-5-yl)-2-methyl-1H-pyrazolo[3,4-b]pyridin-3(2H)-one; 
 (R)-1-(2-(difluoromethoxy)benzyl)-2-(difluoromethyl)-6-(2-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-6-(2-(4-(2-hydroxyacetyl)piperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 6-(2-((S)-4-((S)-2-aminopropanoyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-1H-indazol-3(2H)-one; 
 (S)-4-((R)-4-(5-(1-(2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)-2-methylpiperazin-1-yl)-3-hydroxy-4-oxobutanoic acid; 
 (S)-6-(2-(4-acetyl-3-(hydroxymethyl)piperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-1-((3-(difluoromethoxy)-6-methylpyridin-2-yl)methyl)-2-methyl-1H-indazol-3(2H)-one; 
 6-(2-(4-acetylpiperazin-1-yl)pyrimidin-5-yl)-1-(5-(hydroxymethyl)-2-(trifluoromethyl)benzyl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-1-(2-chlorobenzyl)-6-(2-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-7-methoxy-2-methyl-1H-indazol-3(2H)-one; 
 (R)-6-(2-(4-acetyl-3-(hydroxymethyl)piperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-1-(2-(difluoromethoxy)-5-methylbenzyl)-6-(2-(4-(2-hydroxyacetyl)-2-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-pyrazolo[3,4-b]pyridin-3(2H)-one; 
 (S)-4-(difluoromethoxy)-3-((2-methyl-3-oxo-6-(2-((R)-3-oxohexahydroimidazo[1,5-a]pyrazin-7(1H)-yl)pyrimidin-5-yl)-2,3-dihydro-1H-indazol-1-yl)methyl)benzyl 2-amino-3-methylbutanoate; 
 (S)-7-(5-(1-((3-(difluoromethoxy)-6-methylpyridin-2-yl)methyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)hexahydroimidazo[1,5-a]pyrazin-3(2H)-one; 
 (R)-9-((6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-1-yl)methyl)-4,5-dihydrobenzo[f][1,4]thiazepin-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-5-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 6-(2-((R)-4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)-5-(2-hydroxypropyl)benzyl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-methylbenzyl)-5-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-pyrazolo[3,4-b]pyridin-3(2H)-one; 
 (R)-1-(2-(difluoromethoxy)benzyl)-6-(2-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-5-methoxy-2-methyl-1H-indazol-3(2H)-one; 
 (R)-1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-6-(2-(3-methylpiperazin-1-yl)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(5-(1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)pyrrolidine-3-carboxamide; 
 1-(2-(difluoromethoxy)-5-methylbenzyl)-6-(2-(2-hydroxypropan-2-yl)-4-methylpyrimidin-5-yl)-2-methyl-1H-pyrazolo[3,4-b]pyridin-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-6-(2-((3aS,6aS)-4-oxohexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 (R)-6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)-5-((3-methyl-2-oxoimidazolidin-1-yl)methyl)benzyl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-(hydroxymethyl)benzyl)-2-methyl-6-(2-((2-oxopyrrolidin-3-yl)amino)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 2-(difluoromethoxy)-3-((5-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-1-yl)methyl)phenyl)acetonitrile; 
 1-(5-((4H-1,2,4-triazol-4-yl)methyl)-2-(difluoromethoxy)benzyl)-5-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-methylbenzyl)-6-(2-(1-hydroxy-2-methylpropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-(hydroxymethyl)benzyl)-2-methyl-6-(4-((1-methyl-2-oxopyrrolidin-3-yl)amino)phenyl)-1H-indazol-3(2H)-one; 
 (S)-1-(2-(difluoromethoxy)-5-(hydroxymethyl)benzyl)-2-methyl-6-(2-((1-methyl-2-oxopiperidin-4-yl)amino)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 6-(2-((R)-4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1-(1-(6-methylpyridin-2-yl)ethyl)-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-2-methyl-6-(2-((tetrahydro-2H-pyran-3-yl)oxy)pyridin-4-yl)-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-methylbenzyl)-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 6-(2-((R)-4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1-(1-(4-methylpyridin-2-yl)ethyl)-1H-indazol-3(2H)-one; 
 1-(2-chloro-5-((1-methyl-2-oxopiperidin-3-yl)amino)benzyl)-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)—N-(3-((6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-1-yl)methyl)-4-(difluoromethoxy)benzyl)acetamide; 
 (R)-6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-chlorobenzyl)-2-(pyridin-4-ylmethyl)-1H-indazol-3(2H)-one; 
 (S)-4-(difluoromethoxy)-3-((2-methyl-3-oxo-6-(2-((S)-3-oxotetrahydro-1H-oxazolo[3,4-a]pyrazin-7(3H)-yl)pyrimidin-5-yl)-2,3-dihydro-1H-indazol-1-yl)methyl)benzyl 2-amino-3-methylbutanoate; 
 (R)-1-(2-(difluoromethoxy)-5-methylbenzyl)-6-(2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (S)-1-(2-(difluoromethoxy)-5-methylbenzyl)-6-(2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (S)-7-(5-(2-methyl-1-(5-methyl-2-(trifluoromethyl)pyridin-3-yl)methyl)-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)hexahydroimidazo[1,5-a]pyrazin-3(2H)-one; 
 (R)-1-(2-(difluoromethoxy)benzyl)-6-(2-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-3-oxo-2,3-dihydro-1H-indazole-5-carbonitrile; 
 (S)-4-methyl-2-((2-methyl-3-oxo-6-(2-(3-oxohexahydroimidazo[1,5-a]pyrazin-7(1H)-yl)pyrimidin-5-yl)-2,3-dihydro-1H-indazol-1-yl)methyl)benzonitrile; 
 3-(3-((6-(2-((R)-4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-1-yl)methyl)-4-(difluoromethoxy)phenyl)-2-methylpropanenitrile; 
 2-(difluoromethoxy)-3-((6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-1-yl)methyl)phenyl)acetonitrile; 
 (R)-6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)-5-((3-oxo-2,3-dihydro-1H-pyrazol-1-yl)methyl)benzyl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(1-(2-chlorophenyl)ethyl)-6-(2-((R)-4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-3-((6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-chlorobenzyl)-3-oxo-1H-indazol-2(3H)-yl)methyl)benzonitrile; 
 1-(2-(difluoromethoxy)-6-(methoxymethyl)benzyl)-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-((R)-1-(2-fluorophenyl)ethyl)-6-(2-((R)-4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-chloro-5-((pyridin-3-ylmethyl)amino)benzyl)-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-1-(2-chlorobenzyl)-6-(2-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-3-oxo-2,3-dihydro-1H-indazole-7-carbonitrile; 
 (R)-6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)benzyl)-2-(pyridin-4-ylmethyl)-1H-indazol-3(2H)-one; 
 (S)-7-(5-(2-methyl-1-((1-methyl-4-(trifluoromethyl)-1H-pyrazol-3-yl)methyl)-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)hexahydroimidazo[1,5-a]pyrazin-3(2H)-one; 
 3-(1-(5-(1-(2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)piperidin-4-yl)-1,2,4-thiadiazol-5 (4H)-one; 
 1-(2-chloro-5-((1-methyl-2-oxopyrrolidin-3-yl)amino)benzyl)-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-chloro-5-((pyridin-2-ylmethyl)amino)benzyl)-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 methyl 4-(difluoromethoxy)-3-((6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-1-yl)methyl)benzylcarbamate; 
 (S)-7-(5-(2-methyl-3-oxo-1-((2-(fluoromethyl)pyridin-3-yl)methyl)-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)hexahydroimidazo[1,5-a]pyrazin-3(2H)-one; 
 1-(5-(hydroxymethyl)-2-methylbenzyl)-2-methyl-6-(2-morpholinopyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 1-(5-(((1H-pyrazol-3-yl)methyl)amino)-2-chlorobenzyl)-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 6-(2-(4-acetylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)-5-(methoxymethyl)benzyl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)—N-(3-((6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-1-yl)methyl)-4-(difluoromethoxy)benzyl)-N-ethylacetamide; 
 1-((1-((4-ethylpyridin-3-yl)methyl)-4-(trifluoromethyl)-1H-pyrrol-3-yl)methyl)-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-6-(2-(dimethylamino)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 6-(2-(1-acetyl-4-hydroxypiperidin-4-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)benzyl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(5-((1-acetylazetidin-3-yl)methyl)-2-(difluoromethoxy)benzyl)-5-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-((5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)benzyl)-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 6-(2-((R)-4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1-((R)-1-(m-tolyl)ethyl)-1H-indazol-3(2H)-one; 
 6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1-((1-(pyridazin-4-ylmethyl)-4-(trifluoromethyl)-1H-pyrrol-3-yl)methyl)-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-methylbenzyl)-2-(difluoromethyl)-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 (1R,2S)-2-(4-(difluoromethoxy)-3-((6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-1-yl)methyl)phenyl)cyclopentanecarbonitrile; 
 (1R,3S)-3-(4-(difluoromethoxy)-3-((6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-1-yl)methyl)phenyl)cyclopentanecarbonitrile; 
 6-(2-(1-(2-aminoacetyl)-4-hydroxypiperidin-4-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)benzyl)-2-methyl-1H-indazol-3(2H)-one; 
 4-(5-(1-(2-(difluoromethoxy)benzyl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)pyrimidin-2-yl)-4-hydroxypiperidine-1-carbaldehyde; 
 6-(2-((1-acetylpiperidin-4-yl)oxy)pyridin-4-yl)-1-(2-(difluoromethoxy)benzyl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)-5-morpholinobenzyl)-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 1-(2-(difluoromethoxy)benzyl)-6-(2-(3-hydroxy-1-(2-hydroxyacetyl)azetidin-3-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-2-(3-((6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-3-oxo-2,3-dihydro-1H-indazol-1-yl)methyl)-4-(difluoromethoxy)phenyl)acetonitrile; 
 (R)-6-(2-(4-acetyl-2-methylpiperazin-1-yl)-4-methylpyrimidin-5-yl)-1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-1-(2-(difluoromethoxy)benzyl)-5, 7-difluoro-6-(2-(4-(2-hydroxyacetyl)-2-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-6-(2-(4-acetyl-2-methylpiperazin-1-yl)-4-methylpyrimidin-5-yl)-1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-1-(2-(difluoromethoxy)-5-(hydroxymethyl)benzyl)-2-methyl-6-(2-((1-methyl-2-oxopiperidin-4-yl)amino)pyrimidin-5-yl)-1H-indazol-3(2H)-one; 
 (R)-1-(2-(difluoromethoxy)benzyl)-5-fluoro-6-(2-(4-(2-hydroxyacetyl)-3-methylpiperazin-1-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one; 
 (R)-6-(2-(4-acetyl-3-methylpiperazin-1-yl)pyrimidin-5-yl)-1-(2-(difluoromethoxy)-5-methylbenzyl)-2-methyl-d 3 -1H-indazol-3(2H)-one; or 
 (S)-1-(2-chloro-5-((2-hydroxypropyl)amino)benzyl)-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1H-indazol-3(2H)-one. 
 
     
     
         26 . A pharmaceutical composition comprising a compound according to  claim 1  and one or more pharmaceutically acceptable excipients. 
     
     
         27 . A method of treating a disease comprising administering a therapeutically effective amount of a compound or pharmaceutical composition according to  claim 1 . 
     
     
         28 . The method according to  claim 27  wherein the disease is rheumatoid arthritis, juvenile rheumatoid arthritis, psoriasis, psoriatic arthritis, Crohn's disease, inflammatory bowel disease, ulcerative colitis, psoriatic arthritis, psoriasis, ankylosing spondylitis, systemic lupus erythematosus, lupus nephritis, multiple sclerosis, uveitis or hidraenitis suppurativa.