Patient permission-based mobile health-linked information collection and exchange systems and methods

Abstract

A suite of components comprising an objective measurement medical data collection device and a cohort database may standardize, simplify, and objectify clinical outcomes tracking, culminating in population health measurements within the restorative neurosciences such as Parkinson disease individuals diagnosed with a disease. A data collection device may comprise one or more of a gyroscope, an accelerometer, a locator, a camera and a magnetometer for collecting, for example, data related to tremors experienced by the individuals diagnosed with disease and receive instruction data responsive to evaluation of the collected data in relation to the cohort database. A related method collects objective measurements during phases of treatment such as preoperative symptomatology, probabilistic atlas linked targeting for neuromodulation, accountancy for gravitational effects of brain shift during surgery, measurements of movement and quality of life during supervised treatment and ongoing community and self-directed treatment and provides feedback to implants, intelligent devices and users thereof.

What I claim is: 
     
         1 . Apparatus for intracranial surgery comprising
 a first catheter adapted for penetrating the cranium and comprising a delivery channel along its length for delivery of one of an infusion, implanting a device and implanting an electrode,   a neuro-surgical drive for driving the catheter adapted to follow a predetermined intraoperative trajectory from a point of cranial entry to a first target point in the cranium, a digital imaging device for providing at least one digital image of the cranium during the intracranial surgery,   a gravitational sensor for determining the relative position of components of a brain within the cranium with respect to gravity,   wherein the first catheter is advanced within the cranium and the delivery channel is actuated for one of a first infusion, implanting a first device and implanting a first electrode, the first catheter being advanced further for one of a second infusion,   implanting a second device and implanting a second electrode.   
     
     
         2 . Apparatus for intracranial surgery as recited in  claim 1 , further comprising
 a second catheter having a different predetermined intraoperative trajectory adapted for penetrating the cranium at a different location and comprising a delivery channel along its length for delivery of one of an infusion, implanting a device and implanting an electrode.   
     
     
         3 . Apparatus for intracranial surgery as recited in  claim 1  wherein the neuro-surgical drive comprises a micro-drive having three degrees of freedom and a Ben-gun insert perpendicular to the predetermined intraoperative trajectory and parallel to the micro-drive. 
     
     
         4 . Apparatus for intracranial surgery as recited in  claim 1  wherein the digital imaging device comprises one of a CT scan, impedance spectroscopy, ultrasound and magnetic resonance imaging to orient the predetermined trajectory and locating the anterior and posterior commissure with respect to gravitational force applied to the cranium intraoperatively responsive to the gravitational sensor. 
     
     
         5 . Apparatus for intracranial surgery as recited in  claim 1  wherein the gravitational sensor comprises a handheld device including one of a gyroscope and an accelerometer. 
     
     
         6 . Apparatus for intracranial surgery as recited in  claim 4  wherein the digital imaging device is adapted to output a three dimensional volumetric scan of the cranium and included brain components. 
     
     
         7 . Apparatus for intracranial surgery as recited in  claim 6  for delivery of multiple collinear fluidic infusions having a desired predetermined three dimensional shape within the brain. 
     
     
         8 . Apparatus for intracranial surgery as recited in  claim 7  further comprising an automatic reporting system responsive to the three dimensional volumetric scan adapted to alert if a predefined infusion border of the desired three dimensional shape is reached. 
     
     
         9 . Apparatus for intracranial surgery as recited in  claim 6  wherein a time series of three dimensional volumetric scans of the cranium are output to a display device during the intracranial surgery for input to a computer processor. 
     
     
         10 . Apparatus for intracranial surgery as recited in  claim 9  wherein the display device, responsive to the computer processor, is adapted to identify a field location error associated with a cranial implant for correction of the field location error during the intracranial surgery. 
     
     
         11 . Apparatus for intracranial surgery as recited in  claim 9  for delivery of a therapeutic device via the delivery channel of the first catheter, the apparatus further comprising the computer processor adapted for calculating three dimensional locations in the cranium of a plurality of thin-film electrodes of the therapeutic device. 
     
     
         12 . Apparatus for intracranial surgery as recited in  claim 9  for delivering a plurality of collinear fluidic infusions along a desired trajectory by successive advancement of the first catheter, the time series of three dimensional volumetric scans as displayed on the display device adapted to record a three dimensional representation of the shape of the collinear fluidic infusions within the cranium. 
     
     
         13 . Apparatus for intracranial surgery as recited in  claim 12  further comprising a three dimensional printer for real-time shaped infusion monitoring and for providing independent control of one of hydraulic advancement and fluidic delivery responsive to a time series of three dimensional volumetric scans. 
     
     
         14 . Apparatus for intracranial surgery as recited in  claim 9  further comprising a computer processor and memory for recording one of first catheter entry and target points, first catheter impedance, first catheter pressure, and delivery channel infusion pressure for permitting the alteration of one of fluidic flow through the first catheter and delivery of one of a therapeutic device and a fluidic infusion through the first catheter. 
     
     
         15 . Apparatus for intracranial surgery as recited in  claim 13 , the hydraulic advancement actuated by one of mechanical push-pull cabling, screw rotation and hydraulic advancement by fluidic pressure. 
     
     
         16 . Apparatus for intracranial surgery as recited in  claim 9  for use during intracranial surgery and adapted to alter, responsive to computer processor calculation, one of a change in delivery channel pressure over time, regulating pressure to not exceed a maximum delivery channel pressure and to control delivery between a minimum and a maximum insertion with respect to a target point, the apparatus further comprising a plurality of sensors adapted for measuring one of body temperature, line infusate temperature, and molecular weight of infusate for regulating rate of infusion. 
     
     
         17 . Apparatus for intracranial surgery as recited in  claim 11  wherein the plurality of thin-film electrodes comprises a thin-film electrode array adapted to overlay a horizontally situated cortical sulcus located in an anteroposterior location, the array for outputting data to the computer processor and memory, the computer processor adapted for alerting of an abnormality occurring during the intracranial surgery and of a need for the computer processor to alter an electrode stimulation program. 
     
     
         18 . Apparatus for intracranial surgery as recited in  claim 14 , the computer processor for deriving a resulting equation representing an implant trajectory within the cranium and outputting a therapy with reference to a tip of the first catheter at a center of a target point for the therapy. 
     
     
         19 . Apparatus for intracranial surgery as recited in  claim 1  further comprising one of ultrasound, microelectrode recording and impedance spectroscopy adapted to characterize a progression of the advancement of the first catheter for implant or infusion delivery system through brain tissue. 
     
     
         20 . Apparatus for intracranial surgery as recited in  claim 12  wherein the shape of the collinear fluidic infusions within the cranium comprises a triangular arrangement of at least three fluidic infusion clouds.