Solid dressing for treating wounded tissue

Abstract

Disclosed are solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of fibrinogen and a fibrinogen activator, wherein the fibrinogen is present in an amount between 3.0 mg/cm 2 of the wound facing surface of the dressing and 13.0 mg/cm 2 of the wound facing surface of the dressing. Also disclosed are methods for treating wounded tissue.

1 . A solid dressing for treating wounded tissue in a mammal comprising at least one haemostatic layer consisting essentially of fibrinogen and a solvent consisting of water and a fibrinogen activator wherein said haemostatic layer is substantially homogeneous, wherein said fibrinogen is present in an amount about 13.0 mg/cm 2  of the wound facing surface of said dressing, and wherein the moisture content of said solid dressing is from 6% to 44%. 
     
     
         2 . The solid dressing of  claim 1 , further comprising at least one support layer. 
     
     
         3 . The solid dressing of  claim 2 , wherein said support layer comprises a backing material. 
     
     
         4 . The solid dressing of  claim 2 , wherein said support layer comprises an internal support material. 
     
     
         5 . The solid dressing of  claim 2 ; wherein said support layer comprises a resorbable material. 
     
     
         6 . The solid dressing of  claim 2 , wherein said support layer comprises a non resorbable material. 
     
     
         7 . (canceled) 
     
     
         8 . The solid dressing of  claim 3 , further comprising at least physiologically acceptable adhesive between said haemostatic layer and said backing layer. 
     
     
         9 - 11 . (canceled) 
     
     
         12 . The solid dressing of  claim 1 , wherein said haemostatic layer also contains a fibrin crosslinker and/or a source of calcium ions. 
     
     
         13 . The solid dressing of  claim 1 , wherein said haemostatic layer also contains one or more of the following: at least one filler, at least one solubilizing agent, at least one foaming agent and at least one release agent. 
     
     
         14 - 21 . (canceled) 
     
     
         22 . The solid dressing of  claim 1 , wherein said haemostatic layer is composed of a plurality of particles, each of said particles consisting essentially of fibrinogen and thrombin. 
     
     
         23 . The solid dressing of  claim 22 , wherein said haemostatic layer further contains at least one binding agent in an amount effective to improve the adherence of said particles to one another. 
     
     
         24 . (canceled) 
     
     
         25 . The solid dressing of  claim 1 , wherein said haemostatic layer is a monolith. 
     
     
         26 . The solid dressing of  claim 1 , wherein said haemostatic layer has been lyophilized. 
     
     
         27 - 37 . (canceled) 
     
     
         38 . The solid dressing of  claim 1 , wherein said fibrinogen activator is present in an amount between 2.50 Units/mg of fibrinogen component and 0.025 Units/mg of the fibrinogen. 
     
     
         39 . (canceled) 
     
     
         40 . A method of treating wounded tissue in a mammal, comprising placing a solid dressing of  claim 1  to said wounded tissue and applying sufficient pressure to said dressing for a sufficient time for enough fibrin to form to reduce the loss of blood and/or other fluid from said wounded tissue. 
     
     
         41 . The solid dressing of  claim 1 , wherein said moisture content is at least 28%.