Solid dressing for treating wounded tissue

Abstract

Disclosed are solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of a fibrinogen component and a fibrinogen activator, wherein the haemostatic layer(s) is cast or formed from a single aqueous solution containing the fibrinogen component and the fibrinogen activator. Also disclosed are methods for treating wounded tissue using these dressings and frozen compositions useful for preparing the haemostatic layer(s) of these dressings.

1 . A solid dressing for treating wounded tissue in a mammal comprising at least one haemostatic layer consisting essentially of a fibrinogen component and a fibrinogen activator and a solvent consisting of water, wherein said haemostatic layer is substantially homogenous, frozen, and substantially free of fibrin. 
     
     
         2 . (canceled) 
     
     
         3 . The solid dressing of  claim 1 , further comprising at least one support layer. 
     
     
         4 . The solid dressing of  claim 3 , wherein said support layer comprises a backing material. 
     
     
         5 . The solid dressing of  claim 3 , wherein said support layer comprises an internal support material. 
     
     
         6 . The solid dressing of  claim 3 , wherein said support layer comprises a resorbable material. 
     
     
         7 . The solid dressing of  claim 3 , wherein said support layer comprises a non-resorbable material. 
     
     
         8 . The solid dressing of  claim 7 , wherein said non-resorbable material is selected from the group consisting of silicone polymers, paper, gauze and latexes. 
     
     
         9 . The solid dressing of  claim 3 , further comprising at least physiologically acceptable adhesive between said haemostatic layer and said backing layer. 
     
     
         10 . The solid dressing of  claim 6 , wherein said resorbable material is selected from the group consisting of proteinaceous materials and carbohydrate substances. 
     
     
         11 . The solid dressing of  claim 10 , wherein said proteinaceous material is at least one substance selected from the group consisting of keratin, silk, fibrin, collagen and gelatin. 
     
     
         12 . The solid dressing of  claim 10 , wherein said carbohydrate substance is selected from the group consisting of alginic acid and salts thereof, chitin, chitosan, cellulose, n-acetyl glucosamine, proteoglycans, glycolic acid polymers, lactic acid polymers, glycolic acid/lactic acid co-polymers and mixtures of two or more thereof. 
     
     
         13 . The solid dressing of  claim 1 , wherein said haemostatic layer also contains a fibrin cross-linker and/or a source of calcium ions. 
     
     
         14 . The solid dressing of  claim 1 , wherein said haemostatic layer also contains one or more of the following: at least one filler; at least one solubilizing agent; at least one foaming agent; and at least one release agent. 
     
     
         15 . The solid dressing of  claim 14 , wherein said filler is selected from the group consisting of sucrose, lactose, maltose, keratin, silk, fibrin, collagen, gelatin, albumin, polysorbate, chitin, chitosan, alginic acid and salts thereof, cellulose, proteoglycans, glycolic acid polymers, lactic acid polymers, glycolic acid/lactic acid co-polymers, and mixtures of two or more thereof. 
     
     
         16 . The solid dressing of  claim 14 , wherein said solubilizing agent is selected from the group consisting of sucrose, lactose, maltose, dextrose, mannose, trehalose, mannitol, sorbitol, albumin, sorbate, polysorbate, and mixtures of two or more thereof. 
     
     
         17 . The solid dressing of  claim 14 , wherein said release agent is selected from the group consisting of gelatin, mannitol, sorbitol, polysorbate, sorbitan, lactose, maltose, trehalose, sorbate, glucose and mixtures of two or more thereof. 
     
     
         18 . The solid dressing of  claim 14 , wherein said foaming agent is selected from the group consisting of mixtures of sodium bicarbonate/citric acid, sodium bicarbonate/acetic acid, calcium carbonate/citric acid and calcium carbonate/acetic acid. 
     
     
         19 . The solid dressing of  claim 1 , wherein said haemostatic layer also contains at least one therapeutic supplement selected from the group consisting of antibiotics, anticoagulants, steroids, cardiovascular drugs, growth factors, antibodies (poly and mono), chemoattractants, anesthetics, antiproliferatives/antitumor agents, antivirals, cytokines, colony stimulating factors, antifungals, antiparasitics, antiinflammatories, antiseptics, hormones, vitamins, glycoproteins, fibronectin, peptides, proteins, carbohydrates, proteoglycans, antiangiogenins, antigens, nucleotides, lipids, liposomes, fibrinolysis inhibitors and gene therapy reagents. 
     
     
         20 - 24 . (canceled) 
     
     
         25 . The solid dressing of  claim 1 , wherein said haemostatic layer is lyophilized. 
     
     
         26 - 39 . (canceled) 
     
     
         40 . A method of treating wounded tissue in a mammal, comprising placing a solid dressing of  claim 1  to said wounded tissue and applying sufficient pressure to said dressing for a sufficient time for enough fibrin to form to reduce the loss of blood and/or other fluid from said wounded tissue. 
     
     
         41 - 43 . (canceled)