US2016324835A1PendingUtilityA1

Methods for improving muscle strength

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Assignee: UNIV WASHINGTONPriority: Feb 2, 2012Filed: Jul 18, 2016Published: Nov 10, 2016
Est. expiryFeb 2, 2032(~5.6 yrs left)· nominal 20-yr term from priority
Inventors:Samuel A. WicklineGregory M. Lanza
A61K 9/0019A61K 9/167A61P 21/00A61K 9/5123A61K 9/51A61K 9/5115A61K 31/436
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Claims

Abstract

The present invention relates to methods for improving muscle strength and treating muscular dystrophy.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A method for increasing muscle strength in a subject that has muscular dystrophy, the method comprising administering rapamycin-loaded nanoparticles. 
     
     
         2 . The method for  claim 1 , wherein the administration of rapamycin-loaded nanoparticles attenuates muscle destruction. 
     
     
         3 . The method for  claim 1 , wherein the administration of rapamycin-loaded nanoparticles induces autophagy. 
     
     
         4 . The method for  claim 1 , wherein the rapamycin-loaded nanoparticles are administered intravenously. 
     
     
         5 . The method for  claim 1 , wherein the rapamycin-loaded nanoparticles comprise between about 0.1 and 0.5% rapamycin. 
     
     
         6 . The method for  claim 1 , wherein the rapamycin-loaded nanoparticles are administered at least once a week. 
     
     
         7 . The method for  claim 1 , wherein 1 mL/kg of the rapamycin-loaded nanoparticles are administered at least once a week.

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