Method for treating a protozoal infection

Abstract

Patients inflicted with various clustering chronic diseases require treatment with multiple drugs having distinct mechanisms of action. Accordingly, patients with multiple conditions suffer from cumulative side effects of multiple drugs as well as drug-drug interactions. Embodiments, agents, compounds or drugs of the present invention, such as sesquiterpenes, e.g., Zerumbone, replace an equal or larger number of approved drugs during patient treatment. Examples of disorders prevented or ameliorated by administration of the formulations of this invention include but are not limited to inflammatory diseases that may be, oncological, genetic, ischemic, infectious, neurological, hematological, ophthalmological, rheumatoid, orthopedic, neurological, hematological, kidney, vascular, dermatological, gynecological, or obstetric. The present invention further relates to a method of identifying agents, compounds or drugs useful in preventing or treating CDCP related diseases and conditions as well as other disorders, diseases and conditions treatable or preventable by the same agents, compounds or drugs.

1 . A method for treating a protozoal infection, said method comprising administering a composition in an amount effective for treating the protozoal infection, the composition comprising metronidazole and itraconazole. 
     
     
         2 . The method of  claim 1  wherein the composition comprises metronidazole, ciprofloxacin and itraconazole. 
     
     
         3 . The method of  claim 1  wherein the composition comprises metronidazole, itraconazole and a non-approved drug. 
     
     
         4 . The method of  claim 1  wherein the composition comprises metronidazole, itraconazole and a sesquiterpene. 
     
     
         5 . The method of  claim 1  wherein metronidazole and ciprofloxacin are combined with itraconazole to treat a protozoal disease with synergistic efficacy. 
     
     
         6 . The method of  claim 1  wherein the composition further comprises agents from the drug classes represented by metronidazole and itraconazole and/or additional agent(s). 
     
     
         7 . The method of  claim 1  wherein the composition comprises:
 one or more triazoles selected from Itraconazole, Fluconazole, Isavuconazole, Ravuconazole, Posaconazole, Voriconazole and Terconazole; 
 and, one or more nitroimidazoles selected from Metronidazole, Tinidazole, Nitroimidazole, Azanidazole, Secnidazole, Ornidazole, Propenidazole, and Nimorazole. 
 
     
     
         8 . The method of  claim 1  wherein the composition comprises:
 one or more agents selected from triazoles selected from Itraconazole, Fluconazole, Isauiconaole Ravticonazole, Posaconazole, Voriconazole and Terconazole; 
 one or more nitroimidazoles selected from Metronidazole, Tinidazole, Nitroimidazole, Azanidazole, Secnidazole, Omidazole, Propenidazole, and Nimorazole; 
 one or more drug selected from mefloquine, doxycycline, choroquine, hydroxychoroquine, Malarone, atovaquone, and Proguanil (Malarone); 
 and/or one more drug selected from an artemisinin-based compound, antimony, amphotericin miltefosine, paromomycin.