Coating For A Surface

Abstract

Coatings for a surface, especially a priming coating, of the present invention have been found to be durable, resistant to oxidative degradation, erosion and depolymerisation, stable to sterilization and low particulating, and are easily applied to the required surface of a substrate in a surface-independent manner. Such coatings, when used as priming coatings to be coated with a subsequent coating, in at least some embodiments, form exterior coatings which are also highly durable and are stable to sterilisation and aging.

1 . A surface having a coating comprising a mixture of components A and B, wherein
 component A is a polymer formed by self-polymerisation of a molecule comprising catechol functionality and amine and/or amide and/or hydroxyl functionality; and   component B comprises a polymer comprising photosensitive or thermosensitive moieties at least some of which moieties form covalent bonds with component A and which polymer forms an interpenetrating network with component A.   
     
     
         2 . A surface having a coating according to  claim 1 , wherein component B is a mixture of a cross-linking molecule comprising two or more photosensitive or thermosensitive moieties, at least some of which moieties form covalent bonds with component A, and a polymer comprising photosensitive or thermosensitive moieties at least some of which moieties form covalent bonds with component A and which polymer forms an interpenetrating network with component A. 
     
     
         3 . A surface having a coating according to  claim 1 , wherein component A is a catecholamine capable of self-polymerisation. 
     
     
         4 . A surface having a coating according to  claim 3 , wherein component A is dopamine. 
     
     
         5 . A surface having a coating according to  claim 1 , wherein the coating is covalently bonded to the surface. 
     
     
         6 . A surface having a coating according to  claim 1 , wherein the one or more photosensitive or thermosensitive moieties component B are capable of hydrogen abstraction. 
     
     
         7 . A surface having a coating according to  claim 6 , wherein the surface comprises abstractable hydrogen atoms and the coating is covalently bonded to the surface via abstraction of hydrogen atoms from the surface by at least some of the photosensitive or thermosensitive moieties of component B. 
     
     
         8 . A surface having a coating according to  claim 1 , wherein component B comprises one or more photosensitive moieties. 
     
     
         9 . A surface having a coating according to  claim 8 , wherein the one or more photosensitive moieties are selected from the group consisting of aryl ketone, diaryl ketone, aryl azide, alkenyl and alkynyl. 
     
     
         10 . A surface having a coating according to  claim 8 , wherein the one or more photosensitive moiety is a Type I or Type II photoinitiator, 
     
     
         11 . A surface having a coating according to  claim 10 , wherein the one or more photosensitive moiety is a Type II photoinitiator. 
     
     
         12 . A surface having a coating according to  claim 11 , wherein one or more photosensitive moiety is a diaryl ketone. 
     
     
         13 . A surface having a coating according to  claim 11 , wherein the one or more photosensitive moiety is benzophenone. 
     
     
         14 . A surface having a coating according to  claim 1 , wherein component B comprises one or more thermosensitive moieties. 
     
     
         15 . A surface having a coating according to  claim 1 , wherein component B comprises one or more photosensitive or thermosensitive moieties capable of forming a carbene or nitrene. 
     
     
         16 . A surface having a coating according to  claim 1 , wherein the surface has a subsequent coating, 
     
     
         17 . A surface having a coating according to  claim 16 , wherein the subsequent a coating is selected from the group consisting of a synthetic or naturally occurring organic or inorganic polymer or material, such as polyolefins, polyesters, polyurethanes, polyamides, polyether block amides, polycarbonates, polyphenylene sulfides, polyphenylene oxides, polyethers, silicones, polycarbonates, polyhydroxyethylmethacrylate polyvinyl pyrrolidone, polyvinyl alcohol, rubber, silicone rubber, polyhydroxyacids, polyallylamine, polyallylalcohol, polyacrylamide, polyamelic acid, styrenic polymers, polytetrafluoroethylene and copolymers thereof, bioresorbables, such as poly(D,L-lactide), polyglycolids and copolymers thereof, non-woven, bioabsorbable web materials comprising a tri-block copolymer such as poly(glycolide-co-trimethylene carbonate) tri-block copolymer (PGA:TMC), nylon 12, nylon 11, nylon 9, nylon 6/9 and nylon 6/6, polyetheresteramide, polyethylene terephthalate and polybutylene terephthalate, polyester ethers, polyester elastomer copolymers, block copolymer elastomers such as those copolymers having styrene end blocks, and midblocks formed from butadiene, isoprene, ethylene/butylene, ethylene/propene, styrenic block copolymers including acrylonitrile-styrene and acrylonitrile-butadiene-styrene block copolymers, polystyrenes, poly(methyl)methacrylates, polyacrylonitriles, poly(vinylacetates), poly(vinyl alcohols), chlorine-containing polymers such as poly(vinyl) chloride, polyoxymethylenes, polycarbonates, polyamides, polyimides, polyurethanes, phenolics, amino-epoxy resins, polyesters, silicones, cellulose-based plastics, rubber-like plastics, fluorinated polymers such as fluoropolymers, e.g. expanded polytetrafluoroethylene (ePTFE), polytetrafluoroethylene (PTFE), fluorinated ethylene-propylene (FEP), perfluorocarbon copolymers, e.g. tetrafluoroethylene perfluoroalkylvinyl ether (TFE/PAVE) copolymers, copolymers of tetrafluoroethylene (TFE) and perfluoromethyl vinyl ether (PMVE), copolymers of TFE with functional monomers that comprise acetate, alcohol, amine, amide, sulfonate, functional groups, expanded polyethylene, polyvinylchloride, polyurethane, silicone, polyethylene, polypropylene, polyurethane, polyglycolic acid, polyesters, polyamides, elastomers and their mixtures, blends and copolymers or derivatives. 
     
     
         18 . A surface having a coating according to  claim 16 , wherein the coating is covalently bonded to the subsequent coating. 
     
     
         19 . A surface having a coating according to  claim 16 , wherein the subsequent coating comprises a therapeutic agent. 
     
     
         20 . A surface having a coating according to  claim 19 , wherein the therapeutic agent is selected from the group consisting of an anti-thrombogenic agent, a hemostatic agent, an anti-angiogenic agent, an angiogenic agents, an anti-microbial agent, an anti-proliferative agent, a proliferative agent and an anti-inflammatory agent, or a combination thereof. 
     
     
         21 . A surface having a coating according to  claim 21 , wherein the surface is the surface of a substrate comprising a medical device. 
     
     
         22 . A surface having a coating according to  claim 21 , wherein the medical device is selected from the group consisting of stents including bifurcated stents, balloon expandable stents and self-expanding stents, stent-grafts including bifurcated stent-drafts, grafts including vascular grafts and bifurcated grafts, dialators, vascular occluders, embolic filters, embolectomy devices, catheters including microcatheters, central venous catheters, peripheral intravenous catheters and hemodialysis catheters, artificial blood vessels, sheaths including retractable sheaths, blood indwelling monitoring devices, artificial heart valves, pacemaker electrodes, guidewires, cardiac leads, cardiopulmonary bypass circuits, cannulae, plugs, drug delivery devices, balloons, tissue patch devices and blood pumps.