Method for Treating Diabetes

Abstract

This application is directed to the use of steroid compounds for the selective inhibition of the enzyme PTP1B in a mammal for the treatment of diabetes.

1 .- 10 . (canceled) 
     
     
         11 . A compound or pharmaceutically acceptable salt thereof selected from the group consisting of: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
     
     
         12 . The compound of  claim 11 , where the compound is 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         13 . The compound of  claim 11 , where the compound is 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         14 . The compound of  claim 11 , where the compound is 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         15 . The compound of  claim 11 , where the compound is 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         16 . The compound of  claim 11 , where the compound is 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         17 . The compound of  claim 11 , where the compound is 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         18 . The compound of  claim 11 , where the compound is 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         19 . A pharmaceutical composition comprising the compound of  claim 12  and a pharmaceutically acceptable diluent or carrier. 
     
     
         20 . A pharmaceutical composition comprising the compound of  claim 13  and a pharmaceutically acceptable diluent or carrier. 
     
     
         21 . A pharmaceutical composition comprising the compound of  claim 14  and a pharmaceutically acceptable diluent or carrier. 
     
     
         22 . A pharmaceutical composition comprising the compound of  claim 15  and a pharmaceutically acceptable diluent or carrier. 
     
     
         23 . A pharmaceutical composition comprising the compound of  claim 16  and a pharmaceutically acceptable diluent or carrier. 
     
     
         24 . A pharmaceutical composition comprising the compound of  claim 17  and a pharmaceutically acceptable diluent or carrier. 
     
     
         25 . A pharmaceutical composition comprising the compound of  claim 18  and a pharmaceutically acceptable diluent or carrier.