Sulfonyl amide derivatives for the treatment of abnormal cell growth

Abstract

The present invention relates to a compound of the formula I wherein R 1 to R 6 , A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

We claim: 
     
         1 . A method of making a compound of Formula (1), or a pharmaceutically acceptable salt thereof, the method comprising: 
       
         
           
           
               
               
           
         
         reacting a compound of Formula (C3): 
       
       
         
           
           
               
               
           
         
         with a compound of Formula (B5): 
       
       
         
           
           
               
               
           
         
         thereby providing the compound of Formula (1), or a pharmaceutically acceptable salt thereof. 
       
     
     
         2 . The method of  claim 1 , wherein the reaction of the compound of Formula (C3) and the compound of Formula (B5) is performed in the presence of a base. 
     
     
         3 . The method of  claim 2 , wherein the base is diethylamine (DIEA). 
     
     
         4 . The method of  claim 1 , wherein the reaction of the compound of Formula (C3) and the compound of Formula (B5) is performed for 20 hours. 
     
     
         5 . The method of  claim 1 , wherein the reaction is performed in the presence of a solvent. 
     
     
         6 . The method of  claim 5 , wherein the solvent is 1,2-dichloroethane (DCE):t-BuOH. 
     
     
         7 . The method of  claim 6 , wherein the 1,2-dichloroethane (DCE):t-BuOH is 1:1 vol:vol. 
     
     
         8 . The method of  claim 1 , wherein the temperature is 80° C. 
     
     
         9 . The method of  claim 1 , wherein isolating the compound of Formula (1) comprises decreasing the temperature of the reaction mixture to ambient temperature. 
     
     
         10 . The method of  claim 9 , wherein the temperature is 25° C. 
     
     
         11 . The method of  claim 9 , wherein isolating the compound of Formula (1) comprises treating the reaction of the compound of Formula (C3) and the compound of Formula (B5) with EtOAc. 
     
     
         12 . The method of  claim 9 , wherein the reaction of the compound of Formula (C3) and the compound of Formula (B5) is washed with water. 
     
     
         13 . The method of  claim 9 , wherein the reaction of the compound of Formula (C3) and the compound of Formula (B5) is dried over MgSO 4 . 
     
     
         14 . The method of  claim 9 , wherein isolating the compound of Formula (1) comprises filtration.