Compositions Comprising 15-HEPE and Methods of Treating or Preventing Cancer and Neurologic Disease

Abstract

The present disclosure provides compositions comprising 15-HEPE and methods of using same for treating and/or preventing cancer and neurological diseases in a subject in need thereof.

What is claimed is: 
     
         1 . A method of treating and/or preventing cancer in a subject in need thereof, the method comprising administering to the subject 15-HEPE or a composition comprising 15-HEPE. 
     
     
         2 . The method of  claim 1 , wherein the 15-HEPE is in free acid form. 
     
     
         3 . The method of  claim 1 , wherein the 15-HEPE is in esterified form. 
     
     
         4 . The method of  claim 3 , wherein the esterified form is an alkyl ester form. 
     
     
         5 . The method of  claim 4 , wherein the esterified form is ethyl ester. 
     
     
         6 . The method of  claim 3 , wherein the esterified form is a triglyceride form. 
     
     
         7 . The method of  claim 1 , wherein the cancer is selected from carcinoma, CNS cancer, liver cancer, hepatocellular carcinoma, skin cancer, prostate cancer, breast cancer, carcinoma, sarcoma, leukaemia, lymphoma-myeloma and CNS cancer. 
     
     
         8 . The method of  claim 1 , wherein the 15-HEPE comprises, consists essentially of, or consists of 15(S)-HEPE or a derivative thereof. 
     
     
         9 . The method of  claim 1 , wherein the 15-HEPE comprises, consists essentially of, or consists of 15(R)-HEPE or a derivative thereof. 
     
     
         10 . A method of treating and/or preventing a CNS disease in a subject in need thereof, the method comprising administering to the subject 15-HEPE or a composition comprising 15-HEPE. 
     
     
         11 . The method of  claim 10 , wherein the 15-HEPE is in free acid form. 
     
     
         12 . The method of  claim 10 , wherein the 15-HEPE is in esterified form. 
     
     
         13 . The method of  claim 12 , wherein the esterified form is an alkyl ester form. 
     
     
         14 . The method of  claim 13 , wherein the esterified form is ethyl ester. 
     
     
         15 . The method of  claim 12 , wherein the esterified form is a triglyceride form. 
     
     
         16 . The method of  claim 10 , wherein the CNS disease is selected from catalepsy, epilepsy, encephalitis, meningitis, migraine, Huntington's, Alzheimer's, Parkinson's, and multiple sclerosis. 
     
     
         17 . The method of  claim 10 , wherein the 15-HEPE comprises, consists essentially of, or consists of 15(S)-HEPE or a derivative thereof. 
     
     
         18 . The method of  claim 10 , wherein the 15-HEPE comprises, consists essentially of, or consists of 15(R)-HEPE or a derivative thereof. 
     
     
         19 . A method of sensitizing cancer cells to radiation therapy in a subject in need thereof, the method comprising administering to the subject 15-HEPE or a composition comprising 15-HEPE and concurrently or thereafter treating cancer cells in the subject with radiation.