Thromboresistant/bactericidal s-nitroso-n-acetylpenicillamine (snap)-doped nitric oxide release polymers with enhanced stability

Abstract

In an example of a method for making an NO-releasing polymeric composition, a discrete RSNO adduct is dissolved in a solvent to form a discrete RSNO adduct solution. A polymer material is soaked in the discrete RSNO adduct solution for a predetermined time to swell the polymer material and impregnate the polymer material with the discrete RSNO adduct.

What is claimed is: 
     
         1 . A method for making an NO-releasing polymeric composition, comprising the steps of:
 dissolving a discrete RSNO adduct in a solvent to form a discrete RSNO adduct solution; and   soaking a polymer material in the discrete RSNO adduct solution for a predetermined time to swell the polymer material and impregnate the polymer material with the discrete RSNO adduct.   
     
     
         2 . The method as defined in  claim 1  wherein the polymer matrix is selected from the group consisting of a siloxane-based polyurethane elastomer, silicone rubber, and a thermoplastic silicone-polycarbonate-urethane, and wherein the discrete RSNO adduct is S-nitroso-N-acetylpenicillamine (SNAP). 
     
     
         3 . The method as defined in  claim 1  wherein the dissolving and the soaking are accomplished at room temperature ranging from about 17° C. to about 24° C. 
     
     
         4 . The method as defined in  claim 1  wherein dissolving is accomplished by:
 adding the S-nitroso-N-acetylpenicillamine (SNAP) to the solvent, wherein the solvent is selected from the group consisting of tetrahydrofuran, chloroform, methylene chloride, cyclohexanone, and combinations thereof; and 
 stirring the solution for a predetermined time. 
 
     
     
         5 . The method as defined in  claim 1 , further comprising completely immersing the polymer material in the discrete RSNO adduct solution prior to the soaking. 
     
     
         6 . The method as defined in  claim 1  wherein the predetermined time is about 24 hours, and wherein the soaking is accomplished in darkness. 
     
     
         7 . The method as defined in  claim 1  wherein after the soaking for the predetermined time, the method further comprises drying the impregnated polymer material in darkness.