Novel sulphur containing lipids for use as food supplement or as medicament

Abstract

The present disclosure relates to lipid compounds of the general formula (I): (I) wherein R 1 is selected from a C 10 -C 22 alkyl, a C 10 -C 22 alkenyl having 1-6 double bonds, and a C 10 -C 22 alkynyl having 1-6 triple bonds; R 2 and R 3 are the same or different substituents; Y is selected from sulphur, sulfoxide, and sulfone; and X represents a carboxylic acid or a derivative thereof, a carboxylic ester, a carboxylic anhydride or a carboxamide; or a pharmaceutically acceptable salt, complex or solvate thereof. The disclosure also relates to pharmaceutical compositions and lipid compositions comprising such compounds, and to such compounds for use as medicaments or for use in therapy, in particular for the treatment of diseases related to the cardiovascular, metabolic and inflammatory disease area.

1 . A lipid compound of formula (I): 
       
         
           
           
               
               
           
         
       
       wherein
 R 1  is selected from a C 10   - C 22  alkyl group, a C 10   - C 22  alkenyl group having 1-6 double bonds, and a C 10 -C 22  alkynyl group having 1-6 triple bonds; 
 R 2  and R 3  are the same or different and may be selected from a group of substituents consisting of a hydrogen atom, a hydroxy group, an alkyl group, a halogen atom, an alkoxy group, an acyloxy group, an acyl group, an alkenyl group, an alkynyl group, an aryl group, an alkylthio group, an alkoxycarbonyl group, a carboxy group, an alkylsulfinyl group, an alkylsulfonyl group, an amino group, and an alkylamino group, provided that R 2  and R 3  cannot both be a hydrogen atom; or 
 R 2  and R 3  can be connected in order to form a cycloalkane like cyclopropane, cyclobutane, cyclopentane or cyclohexane; 
 Y is selected from sulphur, sulfoxide, and sulfone; 
 X represents a carboxylic acid or a derivative thereof, a carboxylic ester or a carboxamide; 
 
       or a pharmaceutically acceptable salt, solvate, solvate of such salt or a prodrug thereof. 
     
     
         2 - 86 . (canceled)