Polymer coating comprising 2-methoxyethyl acrylate units synthesized by surface-initiated atom transfer radical polymerization

Abstract

The present invention relates to preparation of a polymer coating comprising or consisting of polymer chains comprising or consisting of units of 2-methoxyethyl acrylate synthesized by Surface-Initiated Atom Transfer Radical Polymerization (SIATRP) such as ARGET SIATRP or AGET SIATRP and uses of said polymer coating.

1 .- 15 . (canceled) 
     
     
         16 . A polymer coating comprising polymer chains consisting of repeating units of 2-methoxyethyl acrylate (MEA), wherein said polymer chains are straight and covalently bound to a surface of one or more polymer substrate(s) via one or more covalent bonds at an end of each of the straight polymer chains. 
     
     
         17 . The polymer coating of  claim 16 , wherein the straight polymer chains are bound to the surface via initiator groups covalently bound to the polymer substrate. 
     
     
         18 . The polymer coating of  claim 17 , wherein the initiator groups are alkyl halide initiators. 
     
     
         19 . The polymer coating according to  claim 16 , wherein the polymer coating is obtained or obtainable by Surface Initiated Atom Transfer Radical Polymerization (SI ATRP), reverse ATRP, Simultaneous Reverse and Normal Initiation (SR and NI) ATRP, Initiators for Continuous Activator Regeneration (ICAR) ATRP, Activators Generated by Electron Transfer (AGET) ATRP, or Activator Regenerated by Electron Transfer (ARGET) ATRP. 
     
     
         20 . The polymer coating according to  claim 16 , wherein said straight polymer chains comprises at least 5 MEA units. 
     
     
         21 . The polymer according to  claim 16 , wherein at least 50% of the straight polymer chains comprise at least 5 MEA units. 
     
     
         22 . The polymer coating according to  claim 16 , wherein the substrate is selected from the group consisting of Poly(ether ether ketone) (PEEK), Polypropylene (PP), Polyethylene (PE) (including linear low density polyethylene (LLDPE), low density polyethylene (LDPE) high density polyethylene (HDPE), ultra high molecular weight polyethylene (UHMWPE), and cross-linked polyethylene (PEX)), Poly(ethylene terephthalate) (PET), poly(propylene terephthalate (PPT), PPT/PET copolyester, Polybutylene terephthalate (PBT), Poly(vinyl chloride) (PVC), Polyamide/nylon (PA), Polycarbonate (PC), Cyclic olefin copolymer (COC), Filter paper, Cotton, Cellulose, Poly(4-vinylbenzyl chloride) (PVBC), Poly(vinylidene fluoride) (PVDF), Polystyrene (PS), Toyopearl®, Hydrogels, Polyimide (PI), 1,2-Polybutadiene (PB), Liquid silicon rubber (LSR), poly(dimethylsiloxane) (PDMS), fluoropolymers -and copolymers (e.g. poly(tetrafluoroethylene) (PTFE), Perfluoroethylene propylene copolymer (FEP), Ethylene tetrafluoroethylene copolymer (ETFE), Polyvinyl fluoride (PVF), Polyvinylidene fluoride (PVDF), Polychlorotrifluoroethylene (PCTFE)), poly(methyl methacrylate) (PMMA), Acrylonitrile butadiene styrene (ABS), styrene acrylonitrile (SAN), polyacrylonitrile (PAN), Polymethylpentene (TPX), Polyoxymethylene (POM), Polysulfone (PSU), polyetherimide (PEI), polyphenylene oxide (PPO), polyethersulfone (PES), Polyphenylene sulfide (PPS), Polyamideimide (PM), Liquid crystal polymer (LCP), Epoxy, Polyurethane (PU), Thermoplastic elastomer (TPE), natural or synthetic rubber, polyisobutylene (PIB), polyisoprene, poly(ethylene-co-propylene), Kraton polymers: Poly(styrene-b-butadiene-b-styrene) (SBS), poly(styrene-b-isoprene-b-styrene) (SIS), poly(styrene-b-(ethylene/butylene)-b-styrene) (SEBS), and poly(styrene-b-(ethylene/propylene)-b-styrene) (SEPS). 
     
     
         23 . The polymer coating of  claim 16 , wherein the substrate is selected from the group consisting of polypropylene, and Poly(ether ether ketone). 
     
     
         24 . The polymer coating of  claim 16 , wherein bacterial growth is inhibited by more than 50% on the surface of the one or more polymer substrate(s) compared to a non-coated substrate. 
     
     
         25 . A device comprising one or more polymer surface(s) to which straight polymer chains consisting of repeating units of 2-methoxyethyl acrylate (MEA) are covalently bound via one or more covalent bonds at an end of each of said straight polymer chains. 
     
     
         26 . The device according to  claim 25 , wherein said device is selected from the group consisting of a container, an implantable device, a tubing device, a membrane, a film, a medical device, cell culture dishes or flasks, bioreactors, syringe, needle, biopsy needle, pipette tip, test tube, slide for microscopic inspection, medicine bottle or ampoule, bag, pouch, implantable device, stent, blood filter, blood storage bag, a blood sample glass or tube, blood filter, a blood circuit, infusion set, pump, a catheter, a pump, an oxygenator, prostheses, and biosensors. 
     
     
         27 . The device according to  claim 25 , wherein said device is selected from the group consisting of a container, an implantable device, a tube, a catheter, a film, a membrane, and a filter. 
     
     
         28 . The device according to  claim 25 , wherein the polymer of said polymer surface is selected from the group consisting of Poly(ether ether ketone) (PEEK), Polypropylene (PP), Polyethylene (PE) (including linear low density polyethylene (LLDPE), low density polyethylene (LDPE) high density polyethylene (HDPE), ultra high molecular weight polyethylene (UHMWPE), and cross-linked polyethylene (PEX)), Poly(ethylene terephthalate) (PET), poly(propylene terephthalate (PPT), PPT/PET copolyester, Polybutylene terephthalate (PBT), Poly(vinyl chloride) (PVC), Polyamide/nylon (PA), Polycarbonate (PC), Cyclic olefin copolymer (COC), Filter paper, Cotton, Cellulose, Poly(4-vinylbenzyl chloride) (PVBC), Poly(vinylidene fluoride) (PVDF), Polystyrene (PS), Toyopearl®, Hydrogels, Polyimide (PI), 1,2-Polybutadiene (PB), Liquid silicon rubber (LSR), poly(dimethylsiloxane) (PDMS), fluoropolymers -and copolymers (e.g. poly(tetrafluoroethylene) (PTFE), Perfluoroethylene propylene copolymer (FEP), Ethylene tetrafluoroethylene copolymer (ETFE), Polyvinyl fluoride (PVF), Polyvinylidene fluoride (PVDF), Polychlorotrifluoroethylene (PCTFE)), poly(methyl methacrylate) (PMMA), Acrylonitrile butadiene styrene (ABS), styrene acrylonitrile (SAN), polyacrylonitrile (PAN), Polymethylpentene (TPX), Polyoxymethylene (POM), Polysulfone (PSU), polyetherimide (PEI), polyphenylene oxide (PPO), polyethersulfone (PES), Polyphenylene sulfide (PPS), Polyamideimide (PAI), Liquid crystal polymer (LCP), Epoxy, Polyurethane (PU), Thermoplastic elastomer (TPE), natural or synthetic rubber, polyisobutylene (PIB), polyisoprene, poly(ethylene-co-propylene), Kraton polymers: Poly(styrene-b-butadiene-b-styrene) (SBS), poly(styrene-b-isoprene-b-styrene) (SIS), poly(styrene-b-(ethylene/butylene)-b-styrene) (SEB S), and poly(styrene-b-(ethylene/propylene)-b-styrene) (SEPS).