Enema dispenser

Abstract

An enema includes a liquid in a dispenser having a bottle, a nozzle attached to the bottle, and a valve. The valve may be a membrane having a slit and a thickness of at most 0.90 mm. The valve may be attached to the bottle or it may be attached to the nozzle. The enema can be administered more easily, with a lower amount of force. A method of bowel cleansing includes inserting the enema into a rectum and applying a compression force to the enema bottle.

1 - 26 . (canceled) 
     
     
         27 . A dispenser, comprising:
 a bottle comprising a bottle opening;   a nozzle, attached to the bottle at the bottle opening, and comprising a proximal opening, a distal opening, and a lumen between the proximal opening and the distal opening; and   a valve comprising a membrane having a slit and a thickness of 0.05 to 0.90 mm.   
     
     
         28 . The dispenser of  claim 27 , wherein the valve is attached to the bottle opening. 
     
     
         29 . (canceled) 
     
     
         30 . (canceled) 
     
     
         31 . The dispenser of  claim 27 , wherein the valve is attached to the nozzle and extends across the lumen. 
     
     
         32 . The dispenser of  claim 27 , wherein the valve prevents liquid flow from the distal opening into the bottle. 
     
     
         33 - 37 . (canceled) 
     
     
         38 . The enema dispenser of claim  33   27 , further comprising lubricant on the nozzle. 
     
     
         39 . The dispenser of  claim 27 , further comprising a protective shield on the nozzle. 
     
     
         40 . (canceled) 
     
     
         41 . An enema, comprising:
 a bottle comprising a bottle opening;   a nozzle, attached to the bottle at the bottle opening, and comprising a distal opening;   a valve comprising a membrane having a slit, and   a liquid in the bottle;   wherein at least a portion of the liquid can be dispensed through the distal opening when the bottle is compressed with a force of at most 15 Newtons, and   the liquid comprises a unit dose of a composition selected from the group consisting of an aqueous mixture comprising dibasic sodium phosphate and monobasic sodium phosphate, an aqueous mixture comprising bisacodyl, and mineral oil.   
     
     
         42 . (canceled) 
     
     
         43 . The enema of  claim 41 , wherein at least a portion of the liquid can be dispensed through the distal opening when the bottle is compressed with a force of at most 5 Newtons. 
     
     
         44 . The enema of  claim 41 , wherein the liquid comprises a unit dose of an aqueous mixture comprising dibasic sodium phosphate and monobasic sodium phosphate. 
     
     
         45 . The enema of  claim 44 , wherein the unit dose comprises from 6.84 to 7.56 grams dibasic sodium phosphate and from 18.24 to 20.16 grams monobasic sodium phosphate. 
     
     
         46 . The enema of  claim 45 , wherein at least 50% of the unit dose can be dispensed from the distal opening when the bottle is compressed with a force of at most 80 Newtons. 
     
     
         47 . (canceled) 
     
     
         48 . (canceled) 
     
     
         49 . The enema of  claim 44 , wherein the unit dose comprises from 3.42 to 3.78 grams dibasic sodium phosphate and from 9.12 to 10.08 grams monobasic sodium phosphate. 
     
     
         50 . The enema of  claim 49 , wherein at least 50% of the unit dose can be dispensed from the distal opening when the bottle is compressed with a force of at most 80 Newtons. 
     
     
         51 . (canceled) 
     
     
         52 . The enema of  claim 41 , wherein the liquid comprises a unit dose of mineral oil. 
     
     
         53 . The enema of  claim 52 , wherein at least 50% of the unit dose can be dispensed from the distal opening when the bottle is compressed with a force of at most 80 Newtons. 
     
     
         54 . The enema of  claim 41 , wherein liquid flow from the distal opening into the bottle is prevented. 
     
     
         55 . (canceled) 
     
     
         56 . An enema, comprising:
 a bottle comprising a bottle opening;   a nozzle, attached to the bottle at the bottle opening, and comprising a distal opening;   a valve comprising a membrane having a slit, and   at least a unit dose of a liquid, in the bottle;   wherein at least 50% of the unit dose can be dispensed through the distal opening when the bottle is compressed with a force of at most 80 Newtons,   the liquid comprises a unit dose of a composition selected from the group consisting of an aqueous mixture comprising dibasic sodium phosphate and monobasic sodium phosphate, an aqueous mixture comprising bisacodyl, and mineral oil.   
     
     
         57 . (canceled) 
     
     
         58 . The enema of  claim 56 , wherein at least 50% of the unit dose can be dispensed from the distal opening upon application of a compression force to the bottle of at most 40 Newtons. 
     
     
         59 . (canceled) 
     
     
         60 . The enema of  claim 56 , wherein liquid flow from the distal opening into the bottle is prevented. 
     
     
         61 - 66 . (canceled) 
     
     
         67 . The enema of  claim 56 , wherein the membrane has 2 slits.