3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors

Abstract

The present invention relates to 3-cycloalkylaminopyrrolidine derivatives of the formula I: (wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , X, Y and Z are as defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and more specifically as modulators of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoid arthritis.

1 - 57 . (canceled) 
     
     
         58 . A method of preparing a compound of formula 7-7, 
       
         
           
           
               
               
           
         
       
       comprising the steps of
 (1) reacting a compound of 
 
       
         
           
           
               
               
           
         
       
       with a compound of 
       
         
           
           
               
               
           
         
       
       under a first suitable condition, to obtain a compound of 
       
         
           
           
               
               
           
         
         (2) converting the compound of 
       
       
         
           
           
               
               
           
         
       
       under a second suitable condition to obtain a compound of 
       
         
           
           
               
               
           
         
       
       and
 (3) treating the compound of 
 
       
         
           
           
               
               
           
         
       
       under an acidic condition to obtain the compound of formula 7-7.