Hyperspectral tissue oxygenation measurement system

Abstract

The invention is directed to a hyperspectral/multispectral system referred to as the OxyVu-1 system. The hyperspectral imaging technology performs spectral analysis at each point in a two-dimensional scanned a producing an image displaying information derived from the analysis. For the OxyVu-1 system, the spectral analytical methods determined in superficial tissues approximate values of oxygen saturation (HT-Sat), oxyhemoglobin levels (HT-oxy), and deoxyhemoglobin levels (HT-deoxy). The OxyVu-1 system displays the tissue oxygenation in a two-dimensional, color-coded image. The system contains a system console, a cart, system electronics, CPU, monitor, keyboard, pointing device and printer. The hyperspectral instrument head with support arm contains broadband illuminator, camera and spectral filter for collecting hyperspectral imaging cube. The single use OxyVu Check Pads and Targets are used to perform an instrument check prior to patient measurements. The OxyVu Target is placed within the intended field of view and is used as a fiduciary mark for image registration and for focusing.

1 . A non-invasive, tissue oxygenation measurement system comprising:
 a hyperspectral/multispectral imaging camera that reports an approximate value of: oxygen saturation, oxyhemoglobin level, and deoxyhemoglobin level in superficial tissue;   a display for projecting two-dimensional color-coded images of tissue oxygenation of   a scanned surface of one or more regions of the superficial tissue.   
     
     
         2 . The system of  claim 1 , wherein the oxygenation measurements comprise one or more of: a value for oxyhemoglobin, a value for deoxyhemoglobin, and a value for percent oxygen saturation. 
     
     
         3 . The system of  claim 1 , wherein tissue oxygenation information can be viewed pixel-by-pixel, as a region of interest, or for a viewing area. 
     
     
         4 . The system of  claim 1 , further comprising one or more of a system console, a cart, system electronics, CPU, monitor, keyboard, pointing device and printer. 
     
     
         5 . The system of  claim 1  comprising a hyperspectral instrument head with a support arm, wherein the hyperspectral instrument head contains a broadband illuminator, the camera, and a spectral filter for collecting a three-dimensional matrix of spectral measurements in the form of a hyperspectral imaging cube. 
     
     
         6 . The system of  claim 1 , wherein the two-dimensional images have a 0.1 mm spatial resolution within a 10 cm by 13 cm field of view. 
     
     
         7 . The system of  claim 1 , further comprising a check pad and target, wherein the target is placed within an intended field of view and is used as a fiduciary mark for image registration and for focusing. 
     
     
         8 . The system of  claim 1 , wherein the system provides a tissue oxygenation scan with a 50 micron, 100 micron, 150 micron or 200 micron resolution. 
     
     
         9 . The system of  claim 1 , wherein the system performs the tissue oxygenation measurement in less than 20 seconds per site, less than 15 seconds, less than 10 seconds, less than 5 seconds, or within 2 seconds. 
     
     
         10 . The system of  claim 1 , wherein a patient is not physically contacted by any part of the system. 
     
     
         11 . The system of  claim 1 , wherein the tissue comprises or is near a wound or ulcer. 
     
     
         12 . The system of  claim 1 , wherein the system detects reduced blood flow ischemia states. 
     
     
         13 . The system of  claim 5 , wherein the hyperspectral instrument head is 17 inches from the tissue. 
     
     
         14 . The system of  claim 1 , further comprising a hard drive disk onto which data or displayed information obtained from the system is stored. 
     
     
         15 . The system of  claim 14 , further comprising software which performs a system integrity check. 
     
     
         16 . The system of  claim 15 , wherein the system integrity check comprises calibration, verification of consistency of the software and the data, validation of algorithm software using a known calibration scheme, and verification of operation and functionality of the hard drive disk. 
     
     
         17 . The system of  claim 5 , wherein the broadband illuminator produces polarized visible light. 
     
     
         18 . The system of  claim 1 , wherein the system measures diffusely reflected backscattered light at 15 wavelengths between 500 and 660 nm. 
     
     
         19 . The system of  claim 18 , wherein the backscattered light is measured at increments of 5 nm, 10 nm, 15 nm, 20 nm, 25 nm, 30 nm, 35 nm, 40 nm, or combinations thereof. 
     
     
         20 . The system of  claim 1 , further comprising a two-dimensional CMOS detector. 
     
     
         21 - 40 . (canceled)