Method for treating systemic dna mutation disease

Abstract

The invention is directed to treatment of systemic DNA mutation diseases accompanied with development of somatic mosaicism and elevation of blood extracellular DNA. The inventive method comprises introducing a DNASE enzyme into the systemic blood circulation of a patient in doses and regimens which are sufficient to decrease average molecular weight of circulating extracellular blood DNA in the blood of said patient.

1 . A method for suppressing spread of mutated DNA sequences within the body and development of somatic mosaicism in a subject in need thereof, wherein said method comprises administering a DNase enzyme to said subject, wherein said DNase enzyme is administered in a dose and regimen which is sufficient to decrease the average molecular weight of extracellular blood DNA in the blood of said subject. 
     
     
         2 - 4 . (canceled) 
     
     
         5 . The method according to  claim 1 , wherein said DNase enzyme is administered in a dose and regimen that results in a DNA hydrolytic activity measured in blood plasma that exceeds 1.5 Kunitz units per 1 ml of blood plasma for more than 12 hours within a period of 24 hours. 
     
     
         6 . The method of  claim 1 , wherein the subject has a cancer and the development of somatic mosaicism results from a spread of mutated DNA sequences promoting cancer development. 
     
     
         7 . The method of  claim 6 , wherein the subject has a metastatic cancer and the development of somatic mosaicism results from a spread of mutated DNA sequences promoting metastasis development. 
     
     
         8 . The method of  claim 1 , wherein the subject has a cancer and is receiving a chemotherapy and the development of somatic mosaicism results from a spread of mutated DNA sequences promoting resistance to said cancer chemotherapy.