N-ethyl-n-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide, preparation and uses thereof

Abstract

The subject invention provides a pharmaceutical composition containing laquinimod or a pharmaceutically acceptable salt thereof, and a compound of N-ethyl-N-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide or a salt thereof.

What is claimed is: 
     
         1 - 56 . (canceled) 
     
     
         57 . A sealed package containing a pharmaceutical composition comprising laquinimod or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable carrier, wherein the sealed package is light resistant packaging. 
     
     
         58 . The sealed package of  claim 57 , wherein the light-resistant packaging is an opaque ampule, an opaque bag, an opaque blister pack, an opaque bottle, an opaque can, an opaque carton, an opaque drum, an opaque jar, an opaque pouch or an opaque tube. 
     
     
         59 . The sealed package of  claim 57 , wherein the light-resistant packaging is an opaque blister pack or an opaque high density polyethylene (HPDE) container. 
     
     
         60 . The sealed package of  claim 59 , wherein the opaque blister pack comprises a blend of aluminum and aluminum-silver. 
     
     
         61 . The sealed package of  claim 59 , wherein the opaque blister pack comprises a blend of aluminum and poly-chloro-trifluoro-ethylene. 
     
     
         62 . The sealed package of  claim 59 , wherein the opaque blister pack comprises a blend of two or more of polyvinyl chloride, polyethylene, polycarbonate, polyvinylidene chloride and ethylene vinyl alcohol. 
     
     
         63 . The sealed package of  claim 59 , wherein the opaque high density polyethylene (HDPE) container is an opaque high density polyethylene (HDPE) bottle. 
     
     
         64 . The sealed package of  claim 63 , wherein the opaque high density polyethylene (HDPE) bottle is an opaque high density polyethylene bottle capped with polypropylene child-resistant screw caps fitted with a silica desiccant insert. 
     
     
         65 . The sealed package of  claim 63 , wherein the opaque high density polyethylene (HDPE) bottle is an opaque high density polyethylene bottle capped with polypropylene child-resistant screw caps with aluminum induction seal.