Hydraulic Cements, Methods and Products

Abstract

Non-aqueous, hydraulic cement-forming compositions comprise a non-aqueous mixture of (a) a non-hydrated powder composition comprising calcium aluminate powder, and (b) non-aqueous water-miscible liquid. Hardened cements are formed from such hydraulic cement-forming compositions, and methods of producing hardened cements, kits, and articles of manufacture employ such hydraulic cement-forming compositions.

What is claimed is: 
     
         1 . A non-aqueous, hydraulic cement-forming composition, comprising a non-aqueous mixture of (a) a non-hydrated powder composition comprising calcium aluminate powder, and (b) non-aqueous water-miscible liquid. 
     
     
         2 . The hydraulic cement-forming composition of  claim 1 , wherein the calcium aluminate powder comprises one or more powders selected from the group consisting of (CaO) 3 Al 2 O 3 , (CaO) 12 (Al 2 O 3 ) 7 , and (CaO)Al 2 O 3 . 
     
     
         3 . The hydraulic cement-forming composition of  claim 1 , wherein the calcium aluminate powder comprises (CaO)Al 2 O 3 . 
     
     
         4 . The hydraulic cement-forming composition of  claim 1 , wherein the powder composition comprises at least about 10 weight percent of the calcium aluminate powder, and further comprises from about 3 to about 60 weight % of an agent operable to increase radio-opacity of the composition and/or from about 0.1 to about 15 weight % of microcrystalline silica. 
     
     
         5 . The hydraulic cement-forming composition of  claim 1 , wherein the powder composition comprises at least about 50 weight percent of the calcium aluminate powder, and further comprises from about 3 to about 50 weight % of an agent operable to increase radio-opacity of the composition and/or from about 0.1 to about 5 weight % of microcrystalline silica. 
     
     
         6 . The hydraulic cement-forming composition of  claim 1 , wherein the non-aqueous water-miscible liquid comprises glycerol. 
     
     
         7 . The hydraulic cement-forming composition of  claim 1 , wherein the weight to volume ratio of the powder composition to the non-aqueous water-miscible liquid is in a range of about 0.5:1 to about 10:1. 
     
     
         8 . The hydraulic cement-forming composition of  claim 1 , wherein the weight to volume ratio of the powder composition to the non-aqueous water-miscible liquid is in a range of about 2.5:1 to about 7:1. 
     
     
         9 . The hydraulic cement-forming composition of  claim 1 , wherein the powder composition comprises nanopowders having a grain size of less than 1 micron. 
     
     
         10 . The hydraulic cement-forming composition of  claim 1 , wherein the powder composition comprises nanopowders having a grain size of less than 500 nm. 
     
     
         11 . The hydraulic cement-forming composition of  claim 1 , further comprising one or more components selected from the group consisting of a surfactant operable to facilitate diffusion of water into the composition, a porogen operable to provide a macroporous structure upon hydration, a gelling agent operable to enhance cohesiveness of the composition, an agent operable to increase radio-opacity of the composition, and reinforcing fiber. 
     
     
         12 . The hydraulic cement-forming composition of  claim 1 , further comprising an active pharmaceutical ingredient. 
     
     
         13 . The hydraulic cement-forming composition of  claim 1 , further comprising one or more actives selected from the group consisting of an anti-cancer agent, an antibacterial agent, an analgesic agent, a bisphosphonate, a bone growth promoter, and an anti-inflammatory agent. 
     
     
         14 . A method of producing a hardened cement, comprising contacting the hydraulic cement-forming composition of  claim 1  with a hydration liquid or vapor, the hardened cement comprising calcium aluminate hydrate. 
     
     
         15 . A hardened cement comprising a product formed by contacting the hydraulic cement-forming composition of  claim 1  with a hydration liquid or vapor. 
     
     
         16 . An article of manufacture comprising the hydraulic cement-forming composition of  claim 1  in a dispensing container. 
     
     
         17 . An article of manufacture comprising the hydraulic cement-forming composition of  claim 1  in a dispensing syringe.