Bioresorbable metal alloy and implants made of same

Abstract

Disclosed herein is a non-toxic, bioresorbable, magnesium based alloy for use in production of implants. Specifically exemplified herein are alloy embodiments useful for orthopedic implants. Also disclosed are alloy materials that incorporate magnesium, calcium and strontium.

What is claimed is: 
     
         1 . A bioresorbable, non-toxic, osteogenic magnesium alloy, said alloy comprising, by weight percentage:
 0.3 to 10 percent calcium;   0.3 to 10 percent strontium; and   50 to 99.5 percent magnesium.   
     
     
         2 . The alloy of  claim 1 , wherein said percent of calcium is 1 to 7 wt percent. 
     
     
         3 . The alloy of  claim 1 , wherein said percent of strontium is 1 to 7 wt percent. 
     
     
         4 . The alloy of  claim 1 , wherein said percent of magnesium is 80 to 99 wt percent. 
     
     
         5 . A non-toxic, non-immunoreactive orthopedic implant comprised of the alloy of  claim 1 . 
     
     
         6 . The implant of  claim 5 , wherein said alloy comprises at least 50 percent total weight of said implant. 
     
     
         7 . The implant of  claim 5  fashioned for insertion into a spine of a subject in need. 
     
     
         8 . The implant of  claim 7 , wherein said implant is a cage, dowel or wedge. 
     
     
         9 . The implant of  claim 5 , wherein said implant is a rod, screw, pin or plate. 
     
     
         10 . A method of performing an orthopedic surgery, said surgery comprising inserting the implant of  claim 5  into a subject in need. 
     
     
         11 . An implant for use in orthopedic surgery, said implant comprising an alloy consisting essentially of magnesium, calcium and strontium. 
     
     
         12 . The alloy of  claim 1 , substantially free from aluminum, manganese, zirconium and/or zinc. 
     
     
         13 . A dental implant comprised of the alloy of  claim 1 . 
     
     
         14 . A method of orthopedic surgery which comprises surgically positioning the implant of  claim 5  against a bone of a subject in need thereof. 
     
     
         15 . The implant of  claim 5 , wherein said implant is a prosthetic femoral hip joint; a prosthetic femoral head; a prosthetic acetabular cup; a prosthetic elbow; a prosthetic knee; a prosthetic shoulder; a prosthetic wrist; a prosthetic ankle; a prosthetic hand; a prosthetic finger; a prosthetic toe; a prosthetic vertebrae; a prosthetic spinal disc; a prosthetic cochlea; a prosthetic vessel; or a prosthetic heart valve. 
     
     
         16 . An alloy of  claim 1 , said alloy further comprising an osteogenic growth factor, hormone, nucleic acid sequence or drug. 
     
     
         17 . The implant of  claim 5 , wherein said implant further comprises an osteogenic growth factor, hormone, nucleic acid sequence or drug. 
     
     
         18 . The alloy of  claim 1 , wherein said calcium percent is 0.5-7 wt %. 
     
     
         19 . The alloy of  claim 1 , wherein said strontium percent is 0.5-3.5 wt %.