Antiviral compounds

Abstract

The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

1 - 103 . (canceled) 
     
     
         104 . A compound of the formula: 
       
         
           
           
               
               
           
         
         wherein:
 R 1  is selected from H, methyl, ethyl, and benzyl; and 
 R 2  is selected from ethyl, n-propyl, isopropyl, n-butyl, isobutyl, CH 2 -cyclopropyl, CH 2 -cyclobutyl, n-pentyl, and benzyl; 
 or a pharmaceutically acceptable salt thereof. 
 
       
     
     
         105 . The compound of  claim 104 , wherein R 1  is H, methyl, or ethyl. 
     
     
         106 . The compound of  claim 104 , wherein R 1  is methyl or ethyl. 
     
     
         107 . The compound of  claim 104 , wherein R 1  is methyl. 
     
     
         108 . The compound of  claim 104 , wherein R 2  is ethyl, n-propyl, isopropyl, n-butyl, isobutyl, or n-pentyl. 
     
     
         109 . The compound of  claim 104 , wherein R 2  is ethyl, n-propyl, n-butyl, or n-pentyl. 
     
     
         110 . The compound of  claim 104 , wherein R 2  is ethyl. 
     
     
         111 . The compound of  claim 104 , wherein the compound is 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         112 . The compound of  claim 104 , wherein the compound is 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         113 . A pharmaceutical composition comprising a compound of  claim 104 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipients or carriers.