US2017088608A1PendingUtilityA1

Polypeptides With Enhanced Anti-Inflammatory And Decreased Cytotoxic Properties And Relating Methods

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Assignee: UNIV ROCKEFELLERPriority: Nov 7, 2005Filed: Oct 7, 2016Published: Mar 30, 2017
Est. expiryNov 7, 2025(expired)· nominal 20-yr term from priority
Inventors:Jeffrey V. RavetchFalk NimmerjahnYoshikatsu Kaneko
A61P 37/00A61P 29/00A61K 47/68C07K 2317/41G01N 33/6854A61K 2039/505C12P 21/005C07K 16/18C07K 16/00C07K 2317/52C07K 2317/71C07K 2317/76C07K 16/06
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Abstract

The invention provides a polypeptide containing at least one IgG Fc region, wherein said at least one IgG Fc region is glycosylated with at least one galactose moiety connected to a respective terminal sialic acid moiety by a α 2,6 linkage, and wherein said polypeptide having a higher anti-inflammatory activity as compared to an unpurified antibody.

Claims

exact text as granted — not AI-modified
1 . An isolated polypeptide containing at least one IgG Fc region, having altered properties compared to an unpurified antibody preparation, wherein sialylation of the isolated polypeptide is higher than the sialylation of the unpurified antibody preparation. 
     
     
         2 - 31 . (canceled)

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