Use of free radical scavengers for protecting and treating skin and hair damages caused by chemotherapy

Abstract

The present invention relates to the use of one or more free radical scavengers as prophylactically or therapeutically effective substances and microparticles having an average particle size ranging from 5 to 200 μm for the preparation of a topical pharmaceutical composition for the protection or treatment of skin or hair damages caused by chemotherapeutic treatment. The invention also concerns a method for the protection or treatment of skin and hair damages of a mammal caused by chemotherapy. The invention further relates to a kit for the protection or treatment of hair damages caused by chemotherapeutic treatment consisting of a topical composition comprising microparticles together with free radical scavengers and a shampoo for an effective hair cleaning and supporting the hair treatment. A kit for the protection or treatment of skin damages caused by chemotherapy consisting of a topical composition comprising microparticles together with free radical scavengers and a cleansing milk for an effective skin cleaning and supporting the skin treatment is a further object of the present invention.

1 . A method for the treatment of alopecia caused by chemotherapeutic treatment in a mammal in need thereof, comprising topically administering to the scalp areas of concern of the mammal a prophylactically or therapeutically effective amount of one or more free radical scavengers administered together with microparticles comprising horny sponges and white clay, having an average particle size ranging from 5 to 200 μm;
 Carbomere; 
 Triethanolamine; and 
 Water. 
 
     
     
         2 . The method of  claim 1 , wherein a radical protection factor of the composition constitutes at least 85×10 14  radicals per mg of the composition, measured by determining the number of free radicals in a solution of a test substance (S 1 ) using electron spin resonance (ESR) in comparison with the ESR measurement result of the composition according to the ratio
   RPF=( RC×RF )/PI 
 
       whereby RF=(S 1 −S 2 ) I S 1 ; RC=the concentration of the test substance (radicals/ml); PI=the concentration of the active substance composition (mg/ml); S 2 =signal amplitude of the antioxidant. 
     
     
         3 - 25 . (canceled) 
     
     
         26 . A method for the treatment of alopecia caused by chemotherapeutic treatment in a mammal in need thereof, comprising topically administering to the scalp areas of concern of the mammal a prophylactically or therapeutically effective amount of one or more free radical scavengers administered together with microparticles comprising hard magnetic particles, bamboo powder, silica, and white clay, having an average particle size ranging from 5 to 200 μm;
 Carbomere; 
 Triethanolamine; and 
 Water. 
 
     
     
         27 . A rinse made by the method of  claim 1 . 
     
     
         28 . The rinse of  claim 27 , further comprising a blend of sodium chloride sodium hydroxide in amounts effective to make a shampoo and D-panthenol, tocopherolacetat, propylene glycol, sodium laureth sulfate, TEA-lauryl sulfate, quaternium 80/propylene glycol, citric acid and cococamidopropyl betaine in amounts effective to make a shampoo.