US2017107199A1PendingUtilityA1
Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
Assignee: GLOBAL BLOOD THERAPEUTICS INCPriority: Dec 28, 2011Filed: Dec 27, 2016Published: Apr 20, 2017
Est. expiryDec 28, 2031(~5.5 yrs left)· nominal 20-yr term from priority
C07D 213/65C07D 213/80C07D 401/14C07D 213/69C07D 405/14C07D 487/04C07D 401/12C07D 471/04C07D 213/68C07D 413/12
60
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Claims
Abstract
Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1 . A compound of Formula (I):
or a tautomer or pharmaceutically acceptable salt thereof, wherein
Q is selected from the group consisting of aryl, heteroaryl, and heterocycloalkyl, each optionally substituted with one to three R a ;
Y is O or CR 1a R 1b , where R 1a is H or halo and R 1b is selected from the group consisting of H, halo, and OH;
X is selected from the group consisting of O, >CH(CH 2 ) n R 8 , and C(R 9 ) 2 where n is 0 or 1, R 8 is OH, and R 9 is independently H or halo; or Y—X taken together —NHC(O)— or —C(O)NH—;
R 2 , R 3 , R 4 , and R 5 are independently absent or selected from the group consisting of hydrogen, halo, R b , OR d , O(CH 2 ) 2 OR d , O(CH 2 ) z NR d R d , OC(O)R e , SR d , CN, NO 2 , CO 2 R d , CONR d R d , C(O)R d , OC(O)NR d R d , NR d R d , NR d C(O)R e , NR d C(O) 2 R e , NR d C(O)NR d R d , S(O)R e , S(O) 2 R e , NR d S(O) 2 R e , S(O) 2 NR d R d , and N 3 where z is 1, 2, or 3; or R 5 is —(CH 2 ) p R 5a where p is 0 or 1 and R 5a is OH;
R 6 and R 7 together form oxo or an aldehyde protecting group, or R 6 together with R 1b , R 8 , or R 5 forms a cyclic ether where one of R 1b , R 8 , or R 5a is O, R 6 is a bond, and R 7 is selected from the group consisting of OH, C 1-8 alkoxy, and haloC 1-8 alkoxy;
T 1 , T 2 , T 3 , and T 4 are independently C or N provided that at least one of T 1 , T 2 , T 3 , and T 4 is N and at least one of T 1 , T 2 , T 3 , and T 4 is C;
each R a is independently selected from the group consisting of halo, R b , OR d , O(CH 2 ) u OR d , O(CH 2 ) u NR d R d , O(CH 2 ) u NR d C(O)R e , O(CH 2 ) u NR d C(O) 2 R e , O(CH 2 ) u NR d S(O) 2 R e , NH 2 , —(CH 2 ) k OC(O)R e , —(CH 2 ) k SR d , CN, NO 2 , —(CH 2 ) k CO 2 (C 1-8 alkyl)OH, —(CH 2 ) k CO 2 (C 1-8 alkyl)(heteroaryl)C(O)(C 1-8 alkyl), —(CH 2 ) k CO 2 R d , —(CH 2 ) k CONR d R d , (CH 2 ) k NR d C(O)R e , —(CH 2 ) k NR d (O) 2 R e , —(CH 2 ) k C(O)R d , —(CH 2 ) k OC(O)NR d R d , —NR d (CH 2 ) u OR d , —NR d (CH 2 ) u NR d R d , —NR d (CH 2 ) u NR d C(O)R e , —NR d (CH 2 ) u NR d C(O) 2 R e , —NR d (CH 2 ) u NR d S(O) 2 R e , —(CH 2 ) k NR d C(O)R e , —(CH 2 ) k NR d C(O) 2 R d , —(CH 2 ) k NR d C(O)NR d R d , —(CH 2 ) k S(O)R e , —(CH 2 ) k S(O) 2 R e , —(CH 2 ) k NR d S(O) 2 R e , —C(O)(CH 2 ) k NR d S(O) 2 R e , —(CH 2 ) k C(O)NR d S(O) 2 R e , —(CH) k S(O) 2 NR d R d , N 3 , —(CH 2 ) k aryl optionally substituted with one to three R c , —NR d (CH 2 ) k aryl optionally substituted with one to three R c , —(CH 2 ) k heteroaryl optionally substituted with one to three R c , —NR d (CH 2 ) k heteroaryl optionally substituted with one to three R c , —(CH 2 ) k heterocycloalkyl optionally substituted with one to three R c , and —NR(CH 2 ) k heterocycloalkyl optionally substituted with one to three R c where k is 0, 1, 2, 3, 4, 5, or 6 and u is 1, 2, 3, 4, 5, or 6;
each R b is independently selected from the group consisting of C 1-8 alkyl, C 2-8 alkenyl, and C 2-8 alkynyl, each optionally independently substituted with one to three halo, OR d , or NR d R d ;
each R e is independently selected from the group consisting of halo, C 1-8 alkyl, haloC 1-8 alkyl, C 2-8 alkenyl, haloC 2-8 alkanyl, C 2-8 alkynyl, haloC 2-8 alkynyl, (CH 2 ) m OR f , OC(O)R g , SR f , CN, NO 2 , (CH 2 ) m CO 2 R f , CONR f R f , C(O)R f , OC(O)NR f R f , (CH 2 ) m NR f R f , NR f C(O)R g , NR f C(O) 2 R g , NR f C(O)NR f R f , S(O)R g , S(O) 2 R g , NR f S(O) 2 R g , S(O) 2 NR f R f , N 3 , (R f ) m SiC 1-8 alkyl, heteroaryl optionally substituted with one to three R h , cycloalkyl optionally substituted with one to three R h , and heterocycloalkyl optionally substituted with one to three R h where m is selected from the group consisting of 0, 1, 2, 3, 4, 5, and 6;
each R h is independently selected from the group consisting of halo, C 1-8 alkyl, haloC 1-8 alkyl, OR j , OC(O)R, SR j , NO 2 , CO 2 R j , CONR j R j , C(O)R j , OC(O)NR j R j , NR j R j , NR j C(O)R i , NR j C(O) 2 R i , NR j C(O)NR j R j , S(O)R i , S(O) 2 R i , NR j S(O) 2 R i , and S(O) 2 NR j R j ;
R d , R f , and R j are each independently selected from the group consisting of hydrogen, C 1-8 alkyl, haloC 1-8 alkyl, C 2-8 alkenyl, haloC 2-8 alkenyl, C 2-8 alkynyl, and haloC 2-8 alkynyl; and
R e , R g , and R i are each independently selected from the group consisting of C 1-8 alkyl, haloC 1-8 alkyl, C 2-8 alkenyl, haloC 2-8 alkenyl, C 2-8 alkynyl, and haloC 2-8 alkynyl;
provided that X and Y are not both O;
provided that when X is O, R 1b is not OH; and
provided that when Y is O, and n is 0, R g is not OH.
2 . A according to claim 1 , or a tautomer or pharmaceutically acceptable salt thereof, wherein:
Y is CH 2 ; X is O or CH 2 ; T 1 , T 2 , T 3 , and T 4 are C or N, provided that no more than one of T 1 , T 2 , T 3 , and T 4 is N; Q is selected from the group consisting of i) heteroaryl optionally substituted with one to three R a ; wherein
R 2 , R 3 , R 4 , and R 5 , are independently absent or selected from the group consisting of hydrogen, halo, R b , OR b , O(CH 2 ) z OR d , O(CH 2 ) z NR d R d , OC(O)R e , SR d , CN, NO 2 , CO 2 R d , CONR d R d , C(O)R d , OC(O)NR d R d , NR d R d , NR d C(O)R e , NR d C(O) 2 R e , NR d C(O)NR d R d , S(O)R e , S(O) 2 R e , NR d S(O) 2 R e , S(O)NR d R d , and N 3 where z is 1, 2, or 3;
ii) aryl substituted with one to three —(CH 2 ) k CO 2 R d ; wherein
R 2 and R 5 are independently absent or selected from the group consisting of hydrogen, halo, OR b , O(CH 2 ) z OR d , O(CH 2 ) z NR d R d , OC(O)R e , SR d , CN, NO 2 , CO 2 R d , CONR d R d , C(O)R d , OC(O)NR d R d , NR d R d , NR d C(O)R e , NR d C(O) 2 R e , NR d C(O)NR d R d , S(O)R e , S(O) 2 R e , NR d S(O) 2 R e , S(O) 2 NR d R d , and N 3 where z is 1, 2, or 3;
R 3 and R 4 are independently absent or selected from the group consisting of hydrogen, halo, R b , OR d , O(CH 2 ) z OR d , O(CH 2 ) z NR d R d , OC(O)R e , SR d , CN, NO 2 , CO 2 R d , CONR d R d , C(O)R d , OC(O)NR d R d , NR d R d , NR d C(O)R e , NR d C(O) 2 R e , NR d C(O)NR d R d , S(O)R e , S(O) 2 R e , NR d S(O) 2 R e , S(O) 2 NR d R d , and N 3 where z is 1, 2, or 3;
iii) unsubstituted aryl, wherein
R 2 , R 3 , and R 4 , are independently absent or selected from the group consisting of hydrogen, halo, R b , OR d , O(CH 2 ) z OR d , O(CH 2 ) z NR d R d , OC(O)R e , SR d , CN, NO 2 , CO 2 R d , CONR d R d , C(O)R d , OC(O)NR d R d , NR d R d , NR d C(O)R e , NR d C(O) 2 R e , NR d C(O)NR d R d , S(O)R e , S(O) 2 R e , NR d S(O) 2 R e , S(O) 2 NR d R d , and N 3 where z is 1, 2, or 3; and
R 5 is absent or is OR d ; and
iv) heterocycloalkyl, optionally substituted with one to three R a ; wherein
R 2 , R 3 , R 4 , and R 5 , are independently absent or selected from the group consisting of hydrogen, R b , OR d , O(CH 2 ) z OR d , O(CH 2 ) z NR d R d , OC(O)R e , SR d , CN, NO 2 , CO 2 R d , CONR d R d , C(O)R d , OC(O)NR d R d , NR d R d , NR d C(O)R e , NR d C(O) 2 R e , NR d C(O)NR d R d , S(O)R e , S(O) 2 R e , NR d S(O) 2 R e , S(O) 2 NR d R d , and N 3 where z is 1, 2, or 3;
R 6 and R 7 together form oxo or an aldehyde protecting group; each R a is independently selected from the group consisting of halo, R b , OR d , O(CH 2 ) u OR d , O(CH 2 ) u NR d R d , O(CH 2 ) u NR d C(O)R e , O(CH 2 ) u NR d C(O) 2 R e , O(CH 2 ) u NR d S(O) 2 R e , NH 2 , —(CH 2 ) k OC(O)R e , —(CH 2 ) k SR d , CN, NO 2 , —(CH 2 ) k CO 2 (C 1-8 alkyl)OH, —(CH 2 ) k CO 2 (C 1-8 alkyl)(heteroaryl)C(O)(C 1-8 alkyl), —(CH 2 ) k CO 2 R d , —(CH 2 ) k CONR d R d , —(CH 2 ) k NR d C(O)R e , —NR d (CH 2 ) u NR d R d , —NR d (CH 2 ) u NR d C(O)R e , —NR d (CH 2 ) u NR d C(O) 2 R e , —NR d (CH 2 ) u NR d S(O) 2 R e , —(CH 2 ) k NR d C(O)R e , —(CH 2 ) k NR d C(O) 2 R e , —NR d (CH 2 ) u NR d C(O)NR d R d , —(CH 2 ) k S(O)R e , —(CH 2 ) k S(O) 2 R e , —(CH 2 ) k NR d S(O) 2 R e , —C(O)(CH 2 ) k NR d S(O) 2 R e , —(CH 2 ) k C(O)NR d S(O) 2 R e , —(CH 2 ) k S(O) 2 NR d R d , N 3 , —(CH 2 ) k aryl optionally substituted with one to three R c , —NR d (CH 2 ) k aryl optionally substituted with one to three R c , —(CH 2 ) k heteroaryl optionally substituted with one to three R c , —NR d (CH 2 ) k heteroaryl optionally substituted with one to three R c , —(CH 2 ) k heterocycloalkyl optionally substituted with one to three R c , an —NR d (CH 2 ) k heterocycloalkyl optionally substituted with one to three R c where k is 0, 1, 2, 3, 4, 5, or 6 and u is 1, 2, 3, 4, 5 or 6; each R b is independently selected from the group consisting of C 1-8 alkyl, C 2-8 alkenyl, and C 2-8 alkynyl, each optionally independently substituted with one to three halo, OR d , or NR d R d ; each R e is independently selected from the group consisting of halo, C 1-8 alkyl, haloC 1-8 alkyl, C 2-8 alkenyl, haloC 2-8 alkenyl, C 2-8 alkynyl, haloC 2-8 alkynyl, (CH 2 ) m OR f , OC(O)R g , SR f , CN, NO 3 , (CH 2 ) m CO 2 R f , CONR f R f , C(O)R f , OC(O)NR f R f , (CH 2 ) m NR f R f , NR f C(O)R g , NR f C(O) 2 R g , NR f C(O)NR f R f , S(O)R g , S(O) 2 R g , NR f S(O) 2 R g , S(O) 2 NR f R f , N 3 , (R f ) m SiC 1-8 alkyl, heteroaryl optionally substituted with one to three R h , cycloalkyl optionally substituted with one to three R h , and heterocycloalkyl optionally substituted with one to three R h where m is selected from the group consisting of 0, 1, 2, 3, 4, 5, and 6; each R h is independently selected from the group consisting of halo, C 1-8 alkyl, haloC 1-8 alkyl, OR j , OC(O)R, SR j , NO 2 , CO 2 R j , CONR j R j , C(O)RR, OC(O)NR j R j , NR j R j , NR j C(O)R i , NR h C(O) 2 R i , NR j C(O)NR h R j , S(O)R i , S(O) 2 R i , NR j S(O) 2 R i , and S(O) 2 NR j R j ; R d , R f and R j are each independently selected from the group consisting of hydrogen, C 1-8 alkyl, haloC 1-8 alkyl, C 2-8 alkenyl, haloC 2-8 alkenyl, C 2-8 alkynyl, and haloC 2-8 alkynyl; and R e , R h , and R i are each independently selected from the group consisting of C 1-8 alkyl, haloC 1-8 alkyl, C 2-8 alkenyl, haloC 2-8 alkenyl, C 2-8 alkynyl, and haloC 2-8 alkynyl.
3 . A compound according to claim 2 , or a tautomer or pharmaceutically acceptable salt thereof, wherein R 6 and R 7 together form oxo.
4 . A compound according to claim 2 wherein R 2 and R 3 are independently absent or selected from the group consisting of hydrogen, R b , OR d , O(CH 2 ) z OR d , O(CH 2 ) z NR d R d , OC(O)R e , CO 2 R d , CONR d R d , and C(O)R d , where z is 1, 2, or 3.
5 . A compound according to claim 2 , wherein T 2 is N; R 2 and R 5 are H; R 3 is absent; and R 4 is C 1-8 alkoxy, haloC 1-8 alkoxy, and O(CH 2 ) 2 C 1-8 alkyl.
6 . A compound according to claim 2 , wherein T 2 is N; R 2 and R 4 are H; R 3 is absent; and R 5 is selected from hydroxy and C 1-8 alkoxy.
7 . A compound according to claim 2 , wherein T 4 is N; R 2 and R 3 are H; R 5 is absent; and R 4 is selected from C 1-8 alkyl and C 1-8 alkoxy.
8 . A compound according to any of claims 5 - 7 , wherein Q is selected from the group consisting of an imidazopyridinyl group, a pyrrolopyridinyl group, a pyrazolopyridinyl group, a triazolopyridinyl group, a pyrazolopyrazinyl group, a pyridinyl group, a pyrazinyl group, an oxazolyl group, an imidazolyl group, a triazolyl group, a tetrazolyl group, a pyrazolyl group, a quinolinyl group, an isoquinolinyl group, an indazolyl group, a benzooxazolyl group, a naphthyridinyl group, and a quinoxalinyl group; and wherein Q is optionally substituted with one to three R a .
9 . A compound according to any of claims 5 - 7 , wherein Q is selected from the group consisting of:
and wherein Q is optionally substituted with one to three R a .
10 . A compound accorrding to claim 2 , wherein T 1 is N; R 3 , R 4 , and R 5 are H; and R 2 is absent.
11 . A compound according to claim 2 , wherein T 2 is N; R 2 , R 4 , and R 5 are H; and R 3 is absent.
12 . A compound according to claim 2 , wherein T 3 is N; R 2 , R 3 , and R 5 are H; and R 4 is absent.
13 . A compound according to claim 2 , wherein T 4 is N; R 2 , R 3 , and R 4 are H; and R 5 is absent.
14 . A compound according to any of claims 10 - 13 , wherein Q is selected front the group consisting of an imidazopyridinyl group, a pyrrolopyridinyl group, a pyrazolopyridinyl group, a thiazolopyridinyl group, a pyrazolopyrazinyl group, a pyridinyl group, a pyrazinyl group, an oxazolyl group, an imidazolyl group, a triazolyl group, a tetrazolyl group, a pyrazolyl group, a quinolinyl group, an isoquinolinyl group, an indazolyl group, a benzooxazolyl group, a naphthyridinyl group, and a quinoxalinyl group; and Q is optionally substituted with one to three R a .
15 . A compound according to any of claims 10 - 13 , wherein Q is selected from the group consisting of:
and wherein Q is optionally substituted with one to three R a .
16 . A compound of claim 2 selected from the group consisting of:
4-(pyridin-3-ylmethoxy)nicotinaldehyde,
3-(pyridin-3-ylmethoxy)isonicotinaldehyde,
2-(imidazo[1,2-a]pyridin-8-ylmethoxy)nicotinaldehyde,
3-(imidazo[1,2-a]pyridin-8-ylmethoxy)picolinaldehyde,
5-(imidazo[1,2-a]pyridin-8-ylmethoxy)-1-methoxyisonicotinaldehyde,
3-(imidazo[1,2-a]pyridin-8-ylmethoxy)isonicotinaldehyde,
3-(imidazo[1,5-a]pyridin-8-ylmethoxy)isonicotinaldehyde,
2-methoxy-5-(pyrazolo[1,5-a]pyrazin-3-ylmethoxy)isonicotinaldehyde,
8-((3-formylpyridin-2-yloxy)methyl)imidazo[1,2-a]pyridine-6-carboxamide,
8-((4-formyl-6-methoxypyridin-3-yloxy)methyl)imidazo[1,2-a]pyridine-6-carboxamide,
5-(imidazo[1,2-a]pyridin-8-ylmethoxy)-2-oxo-1,2-dihydropyridine-4-carbaldehyde,
2-(2-(imidazo[1,2-a]pyridin-8-yl)ethyl)nicotinaldehyde,
5-(2-(imidazo[1,2-a]pyridin-8-yl)ethyl)-2-methoxyisonicotinaldehyde,
5-((1H-pyrazolo[3,4-b]pyridin-4-yl)methoxy)-2-methoxyisonicotinaldehyde,
3-((4-formyl-6-methoxypyridin-3-yloxy)methyl)pyrazolo[1,5-a]pyrazine-2-carboxamide,
5-((2-(1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrazine-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-(imidazo[1,2-a]pyridin-2-ylmethoxy)nicotinaldehyde,
2-methoxy-5-((4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)methoxy)isonicotinaldehyde,
2-(imidazo[1,2-a]pyridin-8-ylmethoxy)nicotinaldehyde,
5-(imidazo[1,2-a]pyridin-8-ylmethoxy)-2-methylisonicotinaldehyde,
3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methoxy)isonicotinaldehyde,
3-(imidazo[1,2-a]pyridin-8-ylmethoxy)isonicotinaldehyde,
3-(pyrrolo[1,2-a]pyrazin-6-ylmethoxy)isonicotinaldehyde,
6-((4-formylpyridin-3-yloxy)methyl)pyrrolo[1,2-a]pyrazine-7-carbonitrile,
6-((4-formylpyridin-3-yloxy)methyl)pyrrolo[1,2-a]pyrazine-7-carboxamide,
3-((1H-pyrazolo[3,4-b]pyridin-4-yl)methoxy)isonicotinaldehyde,
3-(pyrazolo[1,5-a]pyrazin-3-ylmethoxy)isonicotinaldehyde,
2-methoxy-5-((6-oxo-1,6-dihydropyridin-3-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-((2-oxo-1,2-dihydropyridin-4-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-(oxazol-5-yl)methoxy)isonicotinaldehyde,
5-((1H-imidazol-5-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((1H-imidazol-2-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((4H-1,2,4-triazol-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((1H-tetrazol-5-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((1H-pyrazol-5-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((1H-pyrazol-4-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-methoxy-5-(oxazol-4-ylmethoxy)isonicotinaldehyde, 2-methoxy-5-((2-methylpyridin-3-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-((4-methylpyridin-3-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-((6-(trifluoromethyl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-((6-methylpyridin-3-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-(pyridin-3-ylmethoxy)isonicotinaldehyde,
2-methoxy-5-((5-methylpyridin-3-yl)methoxy)isonicotinaldehyde,
5-(isoquinolin-1-ylmethoxy)-2-methoxyisonicotinaldehyde,
2-methoxy-5-(quinolin-2-ylmethoxy)isonicotinaldehyde,
2-methoxy-5-(pyridin-4-ylmethoxy)isonicotinaldehyde,
2-methoxy-5-((3-methylpyridin-4-yl)methoxy)isonicotinaldehyde,
5-((3-bromopyridin-4-yl)methoxy)-2-methoxyisonicotinaldehyde,
3-(imidazo[1,2-a]pyridin-8-ylmethoxy)-6-methylpicolinaldehyde,
(5-(imidazo[1,2-a]pyridin-5-ylmethoxy)-2-methoxypyridin-4-yl)(methoxy)methanol,
N-(4-formylpyridin-3-yl)imidazo[1,2-a]pyridine-8-carboxamide,
2-methoxy-5-((6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)methoxy)isonicotinaldehyde,
methyl 2-((4-formyl-6-methoxypyridin-3-yloxy)methyl)imidazo[1,2-a]pyridine-8-carboxylate,
2-methoxy-5-((1-methyl-2-oxo-1,2-dihydropyridin-4-yl)methoxy)isonicotinaldehyde,
5-((3-bromoimidazo[1,2-a]pyridin-2-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((6-bromoimidazo[1,2-a]pyridin-2-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((8-bromoimidazo[1,2-a]pyridin-2-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-methoxy-5-((3-methyl-[1,2,4]triazolo[4,3-a]pyridin-8-yl)methoxy)isonicotinaldehyde,
5-((3-(1H-pyrazol-5-yl)imidazo[1,2-a]pyridin-2-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((6-(1H-pyrazol-3-yl)imidazo[1,2-a]pyridin-2-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-methoxy-5-((8-((1-methyl-1H-pyrazol-5-yl)imidazo[1,2-a]pyridin-2-yl)methoxy)isonicotinaldehyde,
5-((4-formyl-6-methoxypyridin-3-yloxy)methyl)picolinonitrile,
5-((2-bromopyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
3-((4-formyl-6-methoxypyridin-3-yloxy)methyl)picolinonitrile,
5-((2-(1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((5-bromopyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
methyl 2-((4-(1,3-dioxolan-2-yl)-6-methoxypyridin-3-yloxy)methyl)imidazo[1,2-a]pyridine-8-carboxylate,
2-((4-(1,3-dioxolan-2-yl)-6-methoxypyridin-3-yloxy)methyl)imidazo[1,2-a]pyridine-8-carboxamide,
2-((4-(1,3-dioxolan-2-yl)-6-methoxypyridin-3-yloxy)methyl)-N-methylimidazo[1,2-a]pyridine-8-carboxamide,
5-((5-(1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((4-(1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-((4-(dihydroxymethyl)-6-methoxypyridin-3-yloxy)methyl)-N-methylimidazo[1,2-a]pyridine-8-carboxamide,
2-((4-(dihydroxymethyl)-6-methoxypyridin-3-yloxy)methyl)imidazo[1,2-a]pyridine-8-carboxamide,
2-methoxy-5-((5-(1-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-((5-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
5-(5-(1H-pyrazol-4-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-methoxy-5-((5-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
methyl 5-((4-formyl-6-methoxypyridin-3-yloxy)methyl)nicotinate,
5-((4-formyl-6-methoxypyridin-3-yloxy)methyl)nicotinic acid,
2-methoxy-5-(quinolin-3-ylmethoxy)isonicotinaldehyde,
6-methyl-3-(quinolin-3-ylmethoxy)picolinaldehyde,
5-(isoquinolin-7-ylmethoxy)-2-methoxyisonicotinaldehyde,
3-(isoquinolin-7-ylmethoxy)-6-methylpicolinaldehyde,
2-methoxy-5-((1-methyl-1H-indazol-4-yl)methoxy)isonicotinaldehyde,
6-methyl-3-((1-methyl-1H-indazol-4-yl)methoxy)picolinaldehyde,
tert butyl 4-((2-formyl-6-methylpyridin-3-yloxy)methyl)-1H-indazole-1-carboxylate,
5-((1H-indazol-4-yl)methoxy)-2-methoxyisonicotinaldehyde,
3-((1H-indazol-4-yl)methoxy)-6-methylpicolinaldehyde,
6-methoxy-3-((1-methyl-1H-indazol-6-yl)methoxy)picolinaldehyde,
2-methoxy-5-((1-methyl-1H-indazol-7-yl)methoxy)isonicotinaldehyde,
6-methoxy-3-(1-methyl-1H-indazol-6-yl)methoxy)picolinaldehyde,
6-methyl-3-((1-methyl-1H-indazol-7-yl)methoxy)picolinaldehyde,
3-(isoquinolin-1-ylmethoxy)-6-methylpicolinaldehyde,
6-methyl-3-(quinolin-2-ylmethoxy)picolinaldehyde,
5-((4-(1H-pyrazol-4-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((6-bromoimidazo[1,2-a]pyridin-8-yl)methoxy)-2-methoxyisonicotinaldehyde,
8-((4-formyl-6-methoxypyridin-3-yloxy)methyl)imidazo[1,2-a]pyridine-6-carbonitrile,
5-((4-formyl-6-methoxypyridin-3-yloxy)methyl)nicotinonitrile,
3-(benzo[d]oxazol-4-ylmethoxy)-6-methylpicolinaldehyde,
8-((4-formyl-6-methoxypyridin-3-yloxy)methyl)imidazo[1,2-a]pyridine-6-carboxamide,
5-((4-formyl-6-methoxypyridin-3-yloxy)methyl)nicotinamide,
5-((6-((1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-8-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-(benzo[d]oxazol-4-ylmethoxy)-2-methoxyisonicotinaldehyde,
5-((6-(1H-pyrazol-5-yl)imidazo[1,2-a]pyridin-8-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((1,5-naphthyridin-4-yl)methoxy)-2-methoxyisonicotinaldehyde,
3-((1,5-naphthyridin-4-yl)methoxy)-6-methylpicolinaldehyde,
5-((1H-indazol-5-yl)methoxy)-2-methoxyisonicotinaldehyde,
6-methyl-3-((1-methyl-1H-indazol-5-yl)methoxy)picolinaldehyde,
3-((3-chloro-1-methyl-1H-indazol-5-yl)methoxy)-6-methylpicolinaldehyde,
2-methoxy-5-(1-methyl-1H-indazol-5-yl)methoxy)isonicotinaldehyde,
5-((3-chloro-1-methyl-1H-indazol-5-yl)methoxy)-2-methoxyisonicotinaldehyde,
N-(4-formyl-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridine-8-carboxamide,
3-(1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-4-yl)methoxy)-6-methylpicolinaldehyde,
5-((1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-4-yl)methoxy)-2-methoxyisonicotinaldehyde,
3-((4-formyl-6-methoxypyridin-3-yloxy)methyl)picolinamide,
5-((2-chloroquinolin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1H-pyrazol-5-yl)quinolin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-methoxy-5-(quinoxalin-2-ylmethoxy)isonicotinaldehyde,
6-methyl-3-(quinolin-5-ylmethoxy)picolinaldehyde,
2-methoxy-5-(quinolin-5-ylmethoxy)isonicotinaldehyde,
6-methyl-3-((1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methoxy)picolinaldehyde,
2-methoxy-5-((1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methoxy)isonicotinaldehyde,
5-((7-(1H-pyrazol-3-yl)imidazo[1,5-a]pyridin-8-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((5-(2H-tetrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((6-(2H-tetrazol-5-yl)imidazo[1,2-a]pyridin-8-yl)methoxy)-2-methoxyisonicotinaldehyde,
ethyl 2-(5-(imidazo[1,2-a]pyridin-8-ylmethoxy)-2-methoxypyridin-4-yl)thiazolidine-4-carboxylate,
2-methoxy-5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
5-((2-(1H-pyrazol-4-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-methoxy-5-((2-(1-methyl-1H-pyrazol-5-yl)pyridin-1-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-((2-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)methoxyl)isonicotinaldehyde,
5-((2-(2H-tetrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-methoxy-5-((2-(4-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
5-((3-(1H-pyrazol-5-yl)isoquinolin-4-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1H-pyrazol-1-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
3-(2-(1H-pyrazol-1-yl)pyridin-3-yl)methoxy)-6-methylpicolinaldehyde,
6-methyl-3-(pyridin-3-ylmethoxy)picolinaldehyde,
methyl 8-(((4-formyl-6-methoxypyridin-3-yl)oxy)methyl)imidazo[1,2-a]pyridine-6-carboxylate,
methyl 2-bromo-8-(((4-formyl-6-methoxypyridin-3-yl)oxy)methy)imidazo[1,2-a]pyridine-6-carboxylate,
3-(imidazo[1,5-a]pyridin-8-ylmethoxy)-6-methylpicolinaldehyde,
5-(imidazo[1,5-a]pyridin-8-ylmethoxy)-2-methoxyisonicotinaldehyde,
(5-(methoxycarbonyl)pyridin-3-yl)methyl 5-(((4-formyl-6-methoxypyridin-3-yl)oxy)methyl)nicotinate,
5-((2-(1,4-dimethyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1,5-dimethyl-1H-pyrazol-4-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-hydroxyethyl 5-(((4-(1,3-dioxolan-2-yl)-6-methoxypyridin-3-yl)oxy)methyl)nicotinate,
methyl 5-(((4-(1,3-dioxolan-2-yl)-6-methoxypyridin-3-yl)oxy)methyl)nicotinate,
methyl 5-(((4-(bis(2-hydroxyethoxy)methyl)-6-methoxypyridin-3-yl)oxy)methyl)nicotinate,
5-((2-(1,3-dimethyl-1H-pyrazol-4-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1,3-dimethyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1-ethyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-methoxy-5-((2-(3-methyl-1H-pyrazol-1-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
5-(((4-(1,3-dioxolan-2-yl)-6-methoxypyridin-3-yl)oxy)methyl)nicotinic acid,
(E)-2-methoxy-5-((2-(4-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde oxime,
(E)-2-methoxy-5-(pyridin-3-ylmethoxy)isonicotinaldehyde oxime,
2-(5-(imidazo[1,2-a]pyridin-8-ylmethoxy)-2-methoxypyridin-4-yl)thiazolidine,
1-(2-(5-(imidazo[1,2-a]pyridin-8-ylmethoxy)-2-methoxypyridin-4-yl)thiazolidin-3-yl)ethanone, 5-((2-(4-(1H-pyrazol-3-yl)piperazin-1-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-(difluoromethoxy)-5-(imidazo[1,2-a]pyridin-8-yl(methoxy)isonicotinaldehyde,
2-methoxy-5-((2-phenylpyridin-3-yl)methoxy)isonicotinaldehyde,
5-((3-(1-isopropyl-1H-pyrazol-5-yl)pyridin-4-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-([2,3′-bipyridin]-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-methoxy-5-((2-(o-tolyl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-((2′-methoxy-[2,3′-bipyridin]-3-yl)methoxy)isonicotinaldehyde,
4-(((2-formyl-6-methylpyridin-3-yl)oxy)methyl)benzoic acid,
4-(((2-formylpyridin-3-yl)oxy)methyl)benzoic acid,
methyl 3-(((4-formylpyridin-3-yl)oxy)methyl)benzoate,
methyl 3-(((2-formyl-6-methylpyridin-3-yl)oxy)methyl)benzoate,
3-(((4-formylpyridin-3-yl)oxy)methyl)benzoic acid,
3-(((2-formyl-6-methylpyridin-3-yl)oxy)methyl)benzoic acid,
3-(((2-formylpyridin-3-yl)oxy)methyl)benzoic acid,
2-methoxy-5-((2-(1-(2-methoxyethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-((2-(1-propyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-((2-(1-(2,2,2-trifluoromethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
5-((2-(1-(2,2-difluoromethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
3-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)picolinaldehyde,
3-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-6-methylpicolinaldehyde,
2-(difluoromethoxy)-5-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
5-(imidazo[1,2-a]pyridin-8-ylmethoxy)-2-(2-methoxyethoxy)isonicotinaldehyde,
5-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-(2-methoxyethoxy)isonicotinaldehyde,
5-((3-(1-isopropyl-1H-pyrazol-5-yl)pyrazin-2-yl)methoxy)-2-methoxyisonicotinaldehyde,
3-((4-formyl-6-methoxypyridin-3-yloxy)methyl)picolinate,
5-(2-(2-hydroxypropan-2-yl)pyridin-3-yl)methoxy-2-methoxyisonicotinaldehyde,
2-(2-methoxyethoxy)-5-((2-(1-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-(2-methoxyethoxy)-5-((2-(1-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)nicotinaldehyde,
3-hydroxy-5-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
3-(benzyloxy)-5-hydroxyisonicotinaldehyde,
3-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-5-methoxyisonicotinaldehyde,
5-((2-(2-isopropyl-2H-1,2,4-triazol-3-yl)pyridin-3-yl)ethoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1-isopropyl-4-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1-(2-hydroxyethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
6-(((4-formylpyridin-3-yl)oxy)methyl)picolinic acid,
2,2,2-trifluoroacetic acid: 6-(((4-formylpyridin-3-yl)oxy)methyl)picolinic acid (1:1),
2-methoxy-5-((2-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
5-((2-(4-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-oxo-1,2-dihydropyridine-4-carbaldehyde,
5-((2-(1-cyclobutyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1-cyclohexyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1-(cyclohexylmethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1-cyclopentyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-(5-(3-((4-formyl-6-methoxypyridin-3-yloxy)methyl)pyridin-2-yl)-1H-pyrazol-1-yl)acetic acid,
methyl 3-(5-(3-(((4-formyl-6-methoxypyridin-3-yl)oxy)methyl)pyridin-2-yl)-1H-pyrazol-1-yl)propanoate,
3-(3-(3-((4-formyl-6-methoxypyridin-3-yloxy)methyl)pyridin-2-yl)-1H-pyrazol-1-yl)propanoic acid,
3-(5-(3-(((4-formyl-6-methoxypyridin-3-yl)oxy)methyl)pyridin-2-yl)-1H-pyrazol-1-yl)propanoic acid,
3-(((4-formyl-6-methoxypyridin-3-yl)oxy)methyl)benzoic acid,
6-(((4-formylpyridin-3-yl)oxy)methyl)nicotinonitrile 2,2,2-trifluoroacetate,
6-(((4-formylpyridin-3-yl)oxy)methyl)nicotinic acid,
6-(((4-formylpyridin-3-yl)oxy)methyl)nicotinic acid hydrochloride,
6-(((4-formylpyridin-3-yl)oxy)methyl)-N-(methylsulfonyl)nicotinamide,
2,2,2-trifluoroacetic acid 6-(((4-formylpyridin-3-yl)oxy)methyl)-N-(methylsulfonyl)nicotinamide (2:1), 2-(2-methoxyethoxy)-5-((2-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-((2-(1-(3,3,3-trifluoropropyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-(2-methoxyethoxy)-5-((2-(1-(3,3,3-trifluoropropyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-methyl-5-((2-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-methyl-5-((2-(1-(3,3,3-trifluoropropyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
3-((2-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
3-((2-(1-(3,3,3-trifluoropropyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
3-chloro-5-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
3-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-5-methylisonicotinaldehyde,
3-chloro-5-((2-(1-(3,3,3-trifluoropropyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde, and
3-methyl-5-((2-(1-(2,2,2-trifluoromethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
or a tautomer or pharmaceutically acceptable salt thereof.
17 . A compound of claim 2 selected from the group consisting of;
5-(imidazo[1,2-a]pyridin-8-ylmethoxy)-2-methoxyisonicotinaldehyde,
2-methoxy-5-((5-methylpyridin-3-yl)methoxy)isonicotinaldehyde,
5-(isoquinolin-1-ylmethoxy)-2-methoxyisonicotinaldehyde,
2-methoxy-5-(quinolin-2-ylmethoxy)isonicotinaldehyde,
2-methoxy-5-(pyridin-4-ylmethoxy)isonicotinaldehyde,
3-(imidazo[1,2-a]pyridin-8-ylmethoxy)-6-methylpicolinaldehyde,
methyl 2-((4-formyl-6-methoxypyridin-3-yloxy)methyl)imidazo[1,2-a]pyridin-8-carboxylate,
2-methoxy-5-((3-methyl-[1,2,4]triazolo[4,3-a]pyridin-8-yl)methoxy)isonicotinaldehyde,
5-((2-bromopyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((5-bromopyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-methoxy-5-((5-(1-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
5-((4-formyl-6-methoxypyridin-3-yloxy)methyl)nicotinic acid,
2-methoxy-5-(quinolin-3-ylmethoxy)isonicotinaldehyde,
2-methoxy-5-((1-methyl-1H-indazol-4-yl)methoxy)isonicotinaldehyde,
tert-butyl 4-(2-formyl-6-methylpyridin-3-yloxy)methyl)-1H-indazole-1-carboxylate,
6-methyl-3-((1-methyl-1H-indazol-6-yl)methoxy)picolinaldehyde,
6-methyl-3-((1-methyl-1H-indazol-7-yl)methoxy)picolinaldehyde,
3-(isoquinolin-1-ylmethoxy)-6-methylpicolinaldehyde,
5-(benzo[d]oxazol-4-ylmethoxy)-2-methoxyisonicotinaldehyde,
3-((1,5-naphthyridin-4-yl)methoxy)-6-methylpicolinaldehyde,
6-methyl-3-((1-methyl-1H-indazol-5-yl)methoxy)picolinaldehyde,
6-methyl-3-(quinolin-5-ylmethoxy)picolinaldehyde,
2-methoxy-5-(quinolin-5-ylmethoxy)isonicotinaldehyde,
2-methoxy-5-((2-(1-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-((2-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
5-((2-(2H-tetrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-methoxy-5-((2-(4-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
5-((3-(1H-pyrazol-5-yl)isoquinolin-4-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1H-pyrazol-1-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-(imidazo[1,5-a]pyridin-8-ylmethoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1,5-dimethyl-1H-pyrazol-4-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1-ethyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-(difluoromethoxy)-5-(imidazo[1,2-a]pyridin-8-ylmethoxy)isonicotinaldehyde,
2-methoxy-5-((2-phenylpyridin-3-yl)methoxy)isonicotinaldehyde,
5-((3-(1-isopropyl-1H-pyrazol-5-yl)pyridin-4-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-([2,3′-bipyridin]-3-ylmethoxy)-2-methoxyisonicotinaldehyde,
2-methoxy-5-((2-(o-tolyl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-((2′-methoxy-[2,3′-bipyridin]-3-yl)methoxy)isonicotinaldehyde,
4-(((2-formyl-6-methylpyridin-3-yl)oxy)methyl)benzoic acid,
4-(((2-formylpyridin-3-yl)oxy)methyl)benzoic acid,
methyl 3-(((4-formylpyridin-3-yl)oxy)methyl)benzoate,
methyl 3-(((2-formyl-6-methylpyridin-3-yl)oxy)methyl)benzoate,
3-(((4-formylpyridin-3-yl)oxy)methyl)benzoic acid,
3-(((2-formyl-6-methylpyridin-3-yl)oxy)methyl)benzoic acid,
3-(((2-formylpyridin-3-yl)oxy)methyl)benzoic acid,
2-methoxy-5-((2-(1-(2-methoxyethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-((2-(1-propyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxyisonicotinaldehyde,
2-methoxy-5-((2-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
5-((2-(1-(2,2-difluoroethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
3-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)picolinaldehyde,
3-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-6-methylpicolinaldehyde,
2-(difluoromethoxy)-5-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
5-(imidazo[1,2-a]pyridin-8-ylmethoxy)-2-(2-methoxyethoxy)isonicotinaldehyde,
5-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-(2-methoxyethoxy)isonicotinaldehyde,
5-((3-(1-isopropyl-1H-pyrazol-5-yl)pyrazin-2-yl)methoxy)-2-methoxyisonicotinaldehyde,
3-((4-formyl-6-methoxypyridin-3-yloxy)methyl)picolinate,
5-((2-(2-hydroxypropan-2-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-(2-methoxyethoxy)-5-((2-(1-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-(2-methoxyethoxy)-5-((2-(1-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)nicotinaldehyde,
3-hydroxy-5-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
3-(benzyloxy)-5-hydroxyisonicotinaldehyde,
3-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-5-methoxyisonicotinaldehyde,
5-((2-(2-isopropyl-2H-1,2,4-triazol-3-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1-isopropyl-4-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1-(2-hydroxyethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
6-(((4-formylpyridin-3-yl)oxy)methyl)picolinic acid
2,2,2-trifluoroacetic acid: 6-(((4-formylpyridin-3-yl)oxy)methyl)picolinic acid (1:1),
2-methoxy-5-((2-(1-(((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-5-yl)pyridin-3-3-yl)methoxy)isonicotinaldehyde,
5-((2-(4-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy-2-oxy)-2-oxo-1,2-dihydropyridine-4-carbaldehyde,
5-((2-(1-cyclobutyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1-cyclohexyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1-cyclohexylmethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1-cyclopentyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-(5-(3-((4-formyl-6-methoxypyridin-3-yloxy)methyl)pyridin-2-yl)-1H-pyrazol-1-yl)acetic acid,
methyl 3-(5-(3-(((4-formyl-6-methoxypyridin-3-yl)oxy)methyl)pyridin-2-yl)-1H-pyrazol-1-yl)propanoate,
3-(3-(3-((4-formyl-6-methoxypyridin-3-yloxy)methyl)pyridin-2-yl)-1H-pyrazol-1-yl)propanoic acid,
3-(5-(3-(((4-formyl-6-methoxypyridin-3-yl)oxy)methyl)pyridin-2-yl)-1H-pyrazol-1-yl)propanoic acid,
3-(((4-formyl-6-methoxypyridin-3-yl)oxy)methyl)benzoic acid,
6-(((4-formylpyridin-3-yl)oxy)methyl)nicotinonitrile 2,2,2-trifluoroacetate,
6-(((4-formylpyridin-3-yl)oxy)methyl)nicotinic acid,
6-(((4-formylpyridin-3-yl)oxy)methyl)nicotinic acid hydrochloride,
6-(((4-formylpyridin-3-yl)oxy)methyl)-N-(methylsulfonyl)nicotinamide,
2,2,2-trifluoroacetic acid: 6-(((4-formylpyridin-3-yl)oxy)methyl)-N-(methylsulfonyl)nicotinamide (2:1), 2-(2-methoxyethoxy)-5-((2-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-((2-(1-(3,3,3-trifluoropropyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-(2-methoxyethoxy)-5-((2-(1-(3,3,3-trifluoropropyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-methyl-5-((2-(1-(2,2,2-trifluoromethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-methyl-5-((2-(1-(3,3,3-trifluoropropyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
3-((2-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
3-((2-(1-(3,3,3-trifluoropropyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
3-chloro-5-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
3-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-5-methylisonicotinaldehyde,
3-chloro-5-((2-(1-(3,3,3-trifluoropropyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde, and
3-methyl-5-((2-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
or a tautomer or pharmaceutically acceptable salt thereof.
18 . A pharmaceutical composition comprising a compound of any of the preceding claims or a tautomer or pharmaceutically acceptable salt thereof.
19 . A method for increasing tissue oxygenation, the method comprising administering to a subject in need thereof a therapeutically effective amount of a compound of any of the preceding claims or a tautomer or pharmaceutically acceptable salt thereof.
20 . A method for treating a condition associated with oxygen deficiency, the method comprising administering to a subject in need thereof a therapeutically effective amount of a compound of any of the preceding claims or a tautomer or pharmaceutically acceptable salt thereof.
21 . The method of claim 20 , wherein the condition is selected from the group consisting of sickle cell disease, cancer, a pulmonary disorder, stroke, high altitude sickness, an ulcer, a pressure sore, Alzheimer's disease, acute respiratory disease syndrome, and a wound.
22 . The method according to any of claims 19 - 21 wherein the compound is selected from the group consisting of:
4-(pyridin-3-ylmethoxy)nicotinaldehyde,
3-(pyridin-3-ylmethoxy)isonicotinaldehyde,
2-(imidazo[1,2-a]pyridin-8-ylmethoxy)nicotinaldehyde,
3-(imidazo[1,2-a]pyridin-8-ylmethoxy)picolinaldehyde,
5-(imidazo[1,2-a]pyridin-8-ylmethoxy)-1-methoxyisonicotinaldehyde,
3-(imidazo[1,2-a]pyridin-8-ylmethoxy)isonicotinaldehyde,
3-(imidazo[1,5-a]pyridin-8-ylmethoxy)isonicotinaldehyde,
2-methoxy-5-(pyrazolo[1,5-a]pyrazin-3-ylmethoxy)isonicotinaldehyde,
8-((3-formylpyridin-2-yloxy)methyl)imidazo[1,2-a]pyridine-6-carboxamide,
8-((4-formyl-6-methoxypyridin-3-yloxy)methyl)imidazo[1,2-a]pyridine-6-carboxamide,
5-(imidazo[1,2-a]pyridin-8-ylmethoxy)-2-oxo-1,2-dihydropyridine-4-carbaldehyde,
2-(2-(imidazo[1,2-a]pyridin-8-yl)ethyl)nicotinaldehyde,
5-(2-(imidazo[1,2-a]pyridin-8-yl)ethyl)-2-methoxyisonicotinaldehyde,
5-((1H-pyrazolo[3,4-b]pyridin-4-yl)methoxy)-2-methoxyisonicotinaldehyde,
3-((4-formyl-6-methoxypyridin-3-yloxy)methyl)pyrazolo[1,5-a]pyrazine-2-carboxamide,
5-((2-(1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrazine-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-(imidazo[1,2-a]pyridin-2-ylmethoxy)nicotinaldehyde,
2-methoxy-5-((4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)methoxy)isonicotinaldehyde,
2-(imidazo[1,2-a]pyridin-8-ylmethoxy)nicotinaldehyde,
5-(imidazo[1,2-a]pyridin-8-ylmethoxy)-2-methylisonicotinaldehyde,
3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methoxy)isonicotinaldehyde,
3-(imidazo[1,2-a]pyridin-8-ylmethoxy)isonicotinaldehyde,
3-(pyrrolo[1,2-a]pyrazin-6-ylmethoxy)isonicotinaldehyde,
6-((4-formylpyridin-3-yloxy)methyl)pyrrolo[1,2-a]pyrazine-7-carbonitrile,
6-((4-formylpyridin-3-yloxy)methyl)pyrrolo[1,2-a]pyrazine-7-carboxamide,
3-((1H-pyrazolo[3,4-b]pyridin-4-yl)methoxy)isonicotinaldehyde,
3-(pyrazolo[1,5-a]pyrazin-3-ylmethoxy)isonicotinaldehyde,
2-methoxy-5-((6-oxo-1,6-dihydropyridin-3-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-((2-oxo-1,2-dihydropyridin-4-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-(oxazol-5-yl)methoxy)isonicotinaldehyde,
5-((1H-imidazol-5-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((1H-imidazol-2-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((4H-1,2,4-triazol-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((1H-tetrazol-5-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((1H-pyrazol-5-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((1H-pyrazol-4-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-methoxy-5-(oxazol-4-ylmethoxy)isonicotinaldehyde, 2-methoxy-5-((2-methylpyridin-3-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-((4-methylpyridin-3-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-((6-(trifluoromethyl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-((6-methylpyridin-3-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-(pyridin-3-ylmethoxy)isonicotinaldehyde,
2-methoxy-5-((5-methylpyridin-3-yl)methoxy)isonicotinaldehyde,
5-(isoquinolin-1-ylmethoxy)-2-methoxyisonicotinaldehyde,
2-methoxy-5-(quinolin-2-ylmethoxy)isonicotinaldehyde,
2-methoxy-5-(pyridin-4-ylmethoxy)isonicotinaldehyde,
2-methoxy-5-((3-methylpyridin-4-yl)methoxy)isonicotinaldehyde,
5-((3-bromopyridin-4-yl)methoxy)-2-methoxyisonicotinaldehyde,
3-(imidazo[1,2-a]pyridin-8-ylmethoxy)-6-methylpicolinaldehyde,
(5-(imidazo[1,2-a]pyridin-5-ylmethoxy)-2-methoxypyridin-4-yl)(methoxy)methanol,
N-(4-formylpyridin-3-yl)imidazo[1,2-a]pyridine-8-carboxamide,
2-methoxy-5-((6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)methoxy)isonicotinaldehyde,
methyl 2-((4-formyl-6-methoxypyridin-3-yloxy)methyl)imidazo[1,2-a]pyridine-8-carboxylate,
2-methoxy-5-((1-methyl-2-oxo-1,2-dihydropyridin-4-yl)methoxy)isonicotinaldehyde,
5-((3-bromoimidazo[1,2-a]pyridin-2-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((6-bromoimidazo[1,2-a]pyridin-2-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((8-bromoimidazo[1,2-a]pyridin-2-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-methoxy-5-((3-methyl-[1,2,4]triazolo[4,3-a]pyridin-8-yl)methoxy)isonicotinaldehyde,
5-((3-(1H-pyrazol-5-yl)imidazo[1,2-a]pyridin-2-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((6-(1H-pyrazol-3-yl)imidazo[1,2-a]pyridin-2-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-methoxy-5-((8-((1-methyl-1H-pyrazol-5-yl)imidazo[1,2-a]pyridin-2-yl)methoxy)isonicotinaldehyde,
5-((4-formyl-6-methoxypyridin-3-yloxy)methyl)picolinonitrile,
5-((2-bromopyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
3-((4-formyl-6-methoxypyridin-3-yloxy)methyl)picolinonitrile,
5-((2-(1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((5-bromopyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
methyl 2-((4-(1,3-dioxolan-2-yl)-6-methoxypyridin-3-yloxy)methyl)imidazo[1,2-a]pyridine-8-carboxylate,
2-((4-(1,3-dioxolan-2-yl)-6-methoxypyridin-3-yloxy)methyl)imidazo[1,2-a]pyridine-8-carboxamide,
2-((4-(1,3-dioxolan-2-yl)-6-methoxypyridin-3-yloxy)methyl)-N-methylimidazo[1,2-a]pyridine-8-carboxamide,
5-((5-(1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((4-(1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-((4-(dihydroxymethyl)-6-methoxypyridin-3-yloxy)methyl)-N-methylimidazo[1,2-a]pyridine-8-carboxamide,
2-((4-(dihydroxymethyl)-6-methoxypyridin-3-yloxy)methyl)imidazo[1,2-a]pyridine-8-carboxamide,
2-methoxy-5-((5-(1-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-((5-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
5-(5-(1H-pyrazol-4-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-methoxy-5-((5-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
methyl 5-((4-formyl-6-methoxypyridin-3-yloxy)methyl)nicotinate,
5-((4-formyl-6-methoxypyridin-3-yloxy)methyl)nicotinic acid,
2-methoxy-5-(quinolin-3-ylmethoxy)isonicotinaldehyde,
6-methyl-3-(quinolin-3-ylmethoxy)picolinaldehyde,
5-(isoquinolin-7-ylmethoxy)-2-methoxyisonicotinaldehyde,
3-(isoquinolin-7-ylmethoxy)-6-methylpicolinaldehyde,
2-methoxy-5-((1-methyl-1H-indazol-4-yl)methoxy)isonicotinaldehyde,
6-methyl-3-((1-methyl-1H-indazol-4-yl)methoxy)picolinaldehyde,
tert butyl 4-((2-formyl-6-methylpyridin-3-yloxy)methyl)-1H-indazole-1-carboxylate,
5-((1H-indazol-4-yl)methoxy)-2-methoxyisonicotinaldehyde,
3-((1H-indazol-4-yl)methoxy)-6-methylpicolinaldehyde,
6-methoxy-3-((1-methyl-1H-indazol-6-yl)methoxy)picolinaldehyde,
2-methoxy-5-((1-methyl-1H-indazol-7-yl)methoxy)isonicotinaldehyde,
6-methoxy-3-(1-methyl-1H-indazol-6-yl)methoxy)picolinaldehyde,
6-methyl-3-((1-methyl-1H-indazol-7-yl)methoxy)picolinaldehyde,
3-(isoquinolin-1-ylmethoxy)-6-methylpicolinaldehyde,
6-methyl-3-(quinolin-2-ylmethoxy)picolinaldehyde,
5-((4-(1H-pyrazol-4-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((6-bromoimidazo[1,2-a]pyridin-8-yl)methoxy)-2-methoxyisonicotinaldehyde,
8-((4-formyl-6-methoxypyridin-3-yloxy)methyl)imidazo[1,2-a]pyridine-6-carbonitrile,
5-((4-formyl-6-methoxypyridin-3-yloxy)methyl)nicotinonitrile,
3-(benzo[d]oxazol-4-ylmethoxy)-6-methylpicolinaldehyde,
8-((4-formyl-6-methoxypyridin-3-yloxy)methyl)imidazo[1,2-a]pyridine-6-carboxamide,
5-((4-formyl-6-methoxypyridin-3-yloxy)methyl)nicotinamide,
5-((6-((1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-8-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-(benzo[d]oxazol-4-ylmethoxy)-2-methoxyisonicotinaldehyde,
5-((6-(1H-pyrazol-5-yl)imidazo[1,2-a]pyridin-8-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((1,5-naphthyridin-4-yl)methoxy)-2-methoxyisonicotinaldehyde,
3-((1,5-naphthyridin-4-yl)methoxy)-6-methylpicolinaldehyde,
5-((1H-indazol-5-yl)methoxy)-2-methoxyisonicotinaldehyde,
6-methyl-3-((1-methyl-1H-indazol-5-yl)methoxy)picolinaldehyde,
3-((3-chloro-1-methyl-1H-indazol-5-yl)methoxy)-6-methylpicolinaldehyde,
2-methoxy-5-(1-methyl-1H-indazol-5-yl)methoxy)isonicotinaldehyde,
5-((3-chloro-1-methyl-1H-indazol-5-yl)methoxy)-2-methoxyisonicotinaldehyde,
N-(4-formyl-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridine-8-carboxamide,
3-(1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-4-yl)methoxy)-6-methylpicolinaldehyde,
5-((1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-4-yl)methoxy)-2-methoxyisonicotinaldehyde,
3-((4-formyl-6-methoxypyridin-3-yloxy)methyl)picolinamide,
5-((2-chloroquinolin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1H-pyrazol-5-yl)quinolin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-methoxy-5-(quinoxalin-2-ylmethoxy)isonicotinaldehyde,
6-methyl-3-(quinolin-5-ylmethoxy)picolinaldehyde,
2-methoxy-5-(quinolin-5-ylmethoxy)isonicotinaldehyde,
6-methyl-3-((1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methoxy)picolinaldehyde,
2-methoxy-5-((1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methoxy)isonicotinaldehyde,
5-((7-(1H-pyrazol-3-yl)imidazo[1,5-a]pyridin-8-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((5-(2H-tetrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((6-(2H-tetrazol-5-yl)imidazo[1,2-a]pyridin-8-yl)methoxy)-2-methoxyisonicotinaldehyde,
ethyl 2-(5-(imidazo[1,2-a]pyridin-8-ylmethoxy)-2-methoxypyridin-4-yl)thiazolidine-4-carboxylate,
2-methoxy-5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
5-((2-(1H-pyrazol-4-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-methoxy-5-((2-(1-methyl-1H-pyrazol-5-yl)pyridin-1-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-((2-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)methoxyl)isonicotinaldehyde,
5-((2-(2H-tetrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-methoxy-5-((2-(4-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
5-((3-(1H-pyrazol-5-yl)isoquinolin-4-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1H-pyrazol-1-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
3-(2-(1H-pyrazol-1-yl)pyridin-3-yl)methoxy)-6-methylpicolinaldehyde,
6-methyl-3-(pyridin-3-ylmethoxy)picolinaldehyde,
methyl 8-(((4-formyl-6-methoxypyridin-3-yl)oxy)methyl)imidazo[1,2-a]pyridine-6-carboxylate,
methyl 2-bromo-8-(((4-formyl-6-methoxypyridin-3-yl)oxy)methy)imidazo[1,2-a]pyridine-6-carboxylate,
3-(imidazo[1,5-a]pyridin-8-ylmethoxy)-6-methylpicolinaldehyde,
5-(imidazo[1,5-a]pyridin-8-ylmethoxy)-2-methoxyisonicotinaldehyde,
(5-(methoxycarbonyl)pyridin-3-yl)methyl 5-(((4-formyl-6-methoxypyridin-3-yl)oxy)methyl)nicotinate,
5-((2-(1,4-dimethyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1,5-dimethyl-1H-pyrazol-4-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-hydroxyethyl 5-(((4-(1,3-dioxolan-2-yl)-6-methoxypyridin-3-yl)oxy)methyl)nicotinate,
methyl 5-(((4-(1,3-dioxolan-2-yl)-6-methoxypyridin-3-yl)oxy)methyl)nicotinate,
methyl 5-(((4-(bis(2-hydroxyethoxy)methyl)-6-methoxypyridin-3-yl)oxy)methyl)nicotinate,
5-((2-(1,3-dimethyl-1H-pyrazol-4-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1,3-dimethyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1-ethyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-methoxy-5-((2-(3-methyl-1H-pyrazol-1-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
5-(((4-(1,3-dioxolan-2-yl)-6-methoxypyridin-3-yl)oxy)methyl)nicotinic acid,
(E)-2-methoxy-5-((2-(4-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde oxime,
(E)-2-methoxy-5-(pyridin-3-ylmethoxy)isonicotinaldehyde oxime,
2-(5-(imidazo[1,2-a]pyridin-8-ylmethoxy)-2-methoxypyridin-4-yl)thiazolidine,
1-(2-(5-(imidazo[1,2-a]pyridin-8-ylmethoxy)-2-methoxypyridin-4-yl)thiazolidin-3-yl)ethanone, 5-((2-(4-(1H-pyrazol-3-yl)piperazin-1-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-(difluoromethoxy)-5-(imidazo[1,2-a]pyridin-8-yl(methoxy)isonicotinaldehyde,
2-methoxy-5-((2-phenylpyridin-3-yl)methoxy)isonicotinaldehyde,
5-((3-(1-isopropyl-1H-pyrazol-5-yl)pyridin-4-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-([2,3′-bipyridin]-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-methoxy-5-((2-(o-tolyl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-((2′-methoxy-[2,3′-bipyridin]-3-yl)methoxy)isonicotinaldehyde,
methyl-4-(((2-formylpyridin-3-yl)oxy)methyl)benzoate,
4-(((2-formyl-6-methylpyridin-3-yl)oxy)methyl)benzoic acid,
4-(((2-formylpyridin-3-yl)oxy)methyl)benzoic acid,
methyl 3-(((4-formylpyridin-3-yl)oxy)methyl)benzoate,
methyl 3-(((2-formyl-6-methylpyridin-3-yl)oxy)methyl)benzoate,
3-(((4-formylpyridin-3-yl)oxy)methyl)benzoic acid,
3-(((2-formyl-6-methylpyridin-3-yl)oxy)methyl)benzoic acid,
3-(((2-formylpyridin-3-yl)oxy)methyl)benzoic acid,
2-methoxy-5-((2-(1-(2-methoxyethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-((2-(1-propyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-((2-(1-(2,2,2-trifluoromethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
5-((2-(1-(2,2-difluoromethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
3-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)picolinaldehyde,
3-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-6-methylpicolinaldehyde,
2-(difluoromethoxy)-5-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
5-(imidazo[1,2-a]pyridin-8-ylmethoxy)-2-(2-methoxyethoxy)isonicotinaldehyde,
5-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-(2-methoxyethoxy)isonicotinaldehyde,
5-((3-(1-isopropyl-1H-pyrazol-5-yl)pyrazin-2-yl)methoxy)-2-methoxyisonicotinaldehyde,
3-((4-formyl-6-methoxypyridin-3-yloxy)methyl)picolinate,
5-(2-(2-hydroxypropan-2-yl)pyridin-3-yl)methoxy-2-methoxyisonicotinaldehyde,
2-(2-methoxyethoxy)-5-((2-(1-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-(2-methoxyethoxy)-5-((2-(1-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)nicotinaldehyde,
3-hydroxy-5-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
3-(benzyloxy)-5-hydroxyisonicotinaldehyde,
3-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-5-methoxyisonicotinaldehyde,
5-((2-(2-isopropyl-2H-1,2,4-triazol-3-yl)pyridin-3-yl)ethoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1-isopropyl-4-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1-(2-hydroxyethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
6-(((4-formylpyridin-3-yl)oxy)methyl)picolinic acid,
2,2,2-trifluoroacetic acid: 6-(((4-formylpyridin-3-yl)oxy)methyl)picolinic acid (1:1),
2-methoxy-5-((2-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
5-((2-(4-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-oxo-1,2-dihydropyridine-4-carbaldehyde,
5-((2-(1-cyclobutyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1-cyclohexyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1-(cyclohexylmethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
5-((2-(1-cyclopentyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde,
2-(5-(3-((4-formyl-6-methoxypyridin-3-yloxy)methyl)pyridin-2-yl)-1H-pyrazol-1-yl)acetic acid,
methyl 3-(5-(3-(((4-formyl-6-methoxypyridin-3-yl)oxy)methyl)pyridin-2-yl)-1H-pyrazol-1-yl)propanoate,
3-(3-(3-((4-formyl-6-methoxypyridin-3-yloxy)methyl)pyridin-2-yl)-1H-pyrazol-1-yl)propanoic acid,
3-(5-(3-(((4-formyl-6-methoxypyridin-3-yl)oxy)methyl)pyridin-2-yl)-1H-pyrazol-1-yl)propanoic acid,
3-(((4-formyl-6-methoxypyridin-3-yl)oxy)methyl)benzoic acid,
6-(((4-formylpyridin-3-yl)oxy)methyl)nicotinonitrile 2,2,2-trifluoroacetate,
6-(((4-formylpyridin-3-yl)oxy)methyl)nicotinic acid,
6-(((4-formylpyridin-3-yl)oxy)methyl)nicotinic acid hydrochloride,
6-(((4-formylpyridin-3-yl)oxy)methyl)-N-(methylsulfonyl)nicotinamide,
2,2,2-trifluoroacetic acid 6-(((4-formylpyridin-3-yl)oxy)methyl)-N-(methylsulfonyl)nicotinamide (2:1), 2-(2-methoxyethoxy)-5-((2-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-methoxy-5-((2-(1-(3,3,3-trifluoropropyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-(2-methoxyethoxy)-5-((2-(1-(3,3,3-trifluoropropyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-methyl-5-((2-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
2-methyl-5-((2-(1-(3,3,3-trifluoropropyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
3-((2-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
3-((2-(1-(3,3,3-trifluoropropyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
3-chloro-5-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
3-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-5-methylisonicotinaldehyde,
3-chloro-5-((2-(1-(3,3,3-trifluoropropyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde, and
3-methyl-5-((2-(1-(2,2,2-trifluoromethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde,
or a tautomer or pharmaceutically acceptable salt thereof.
23 . The method of claim 22 , wherein the compound is selected from the group consisting of:
5-(imidazo[1,2-a]pyridin-8-ylmethoxy)-2-methoxyisonicotinaldehyde, 2-methoxy-5-((5-methylpyridin-3-yl)methoxy)isonicotinaldehyde, 5-(isoquinolin-1-ylmethoxy)-2-methoxyisonicotinaldehyde, 2-methoxy-5-(quinolin-2-ylmethoxy)isonicotinaldehyde, 2-methoxy-5-(pyridin-4-ylmethoxy)isonicotinaldehyde, 3-(imidazo[1,2-a]pyridin-8-ylmethoxy)-6-methylpicolinaldehyde, methyl 2-((4-formyl-6-methoxypyridin-3-yloxy)methyl)imidazo[1,2-a]pyridin-8-carboxylate, 2-methoxy-5-((3-methyl-[1,2,4]triazolo[4,3-a]pyridin-8-yl)methoxy)isonicotinaldehyde, 5-((2-bromopyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde, 5-((2-(1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde, 5-((5-bromopyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde, 2-methoxy-5-((5-(1-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde, 5-((4-formyl-6-methoxypyridin-3-yloxy)methyl)nicotinic acid, 2-methoxy-5-(quinolin-3-ylmethoxy)isonicotinaldehyde, 2-methoxy-5-((1-methyl-1H-indazol-4-yl)methoxy)isonicotinaldehyde, tert-butyl 4-(2-formyl-6-methylpyridin-3-yloxy)methyl)-1H-indazole-1-carboxylate, 6-methyl-3-((1-methyl-1H-indazol-6-yl)methoxy)picolinaldehyde, 6-methyl-3-((1-methyl-1H-indazol-7-yl)methoxy)picolinaldehyde, 3-(isoquinolin-1-ylmethoxy)-6-methylpicolinaldehyde, 5-(benzo[d]oxazol-4-ylmethoxy)-2-methoxyisonicotinaldehyde, 3-((1,5-naphthyridin-4-yl)methoxy)-6-methylpicolinaldehyde, 6-methyl-3-((1-methyl-1H-indazol-5-yl)methoxy)picolinaldehyde, 6-methyl-3-(quinolin-5-ylmethoxy)picolinaldehyde, 2-methoxy-5-(quinolin-5-ylmethoxy)isonicotinaldehyde, 2-methoxy-5-((2-(1-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde, 2-methoxy-5-((2-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)methoxy)isonicotinaldehyde, 5-((2-(2H-tetrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde, 2-methoxy-5-((2-(4-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde, 5-((3-(1H-pyrazol-5-yl)isoquinolin-4-yl)methoxy)-2-methoxyisonicotinaldehyde, 5-((2-(1H-pyrazol-1-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde, 5-(imidazo[1,5-a]pyridin-8-ylmethoxy)-2-methoxyisonicotinaldehyde, 5-((2-(1,5-dimethyl-1H-pyrazol-4-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde, 5-((2-(1-ethyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde, 5-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde, 2-(difluoromethoxy)-5-(imidazo[1,2-a]pyridin-8-ylmethoxy)isonicotinaldehyde, 2-methoxy-5-((2-phenylpyridin-3-yl)methoxy)isonicotinaldehyde, 5-((3-(1-isopropyl-1H-pyrazol-5-yl)pyridin-4-yl)methoxy)-2-methoxyisonicotinaldehyde, 5-([2,3′-bipyridin]-3-ylmethoxy)-2-methoxyisonicotinaldehyde, 2-methoxy-5-((2-(o-tolyl)pyridin-3-yl)methoxy)isonicotinaldehyde, 2-methoxy-5-((2′-methoxy-[2,3′-bipyridin]-3-yl)methoxy)isonicotinaldehyde, methyl 4-(((2-formylpyridin-2-yl)oxy)methyl)benzoate, 4-(((2-formyl-6-methylpyridin-3-yl)oxy)methyl)benzoic acid, 4-(((2-formylpyridin-3-yl)oxy)methyl)benzoic acid, methyl 3-(((4-formylpyridin-3-yl)oxy)methyl)benzoate, methyl 3-(((2-formyl-6-methylpyridin-3-yl)oxy)methyl)benzoate, 3-(((4-formylpyridin-3-yl)oxy)methyl)benzoic acid, 3-(((2-formyl-6-methylpyridin-3-yl)oxy)methyl)benzoic acid, 3-(((2-formylpyridin-3-yl)oxy)methyl)benzoic acid, 2-methoxy-5-((2-(1-(2-methoxyethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde, 2-methoxy-5-((2-(1-propyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxyisonicotinaldehyde, 2-methoxy-5-((2-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde, 5-((2-(1-(2,2-difluoroethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde, 3-((2(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)picolinaldehyde, 3-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-6-methylpicolinaldehyde, 2-(difluoromethoxy)-5-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde, 5-(imidazo[1,2-a]pyridin-8-ylmethoxy)-2-(2-methoxyethoxy)isonicotinaldehyde, 5-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-(2-methoxyethoxy)isonicotinaldehyde, 5-((3-(1-isopropyl-1H-pyrazol-5-yl)pyrazin-2-yl)methoxy)-2-methoxyisonicotinaldehyde, 3-((4-formyl-6-methoxypyridin-3-yloxy)methyl)picolinate, 5-((2-(2-hydroxypropan-2-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde, 2-(2-methoxyethoxy)-5-((2-(1-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde, 2-(2-methoxyethoxy)-5-((2-(1-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)nicotinaldehyde, 3-hydroxy-5-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde, 3-(benzyloxy)-5-hydroxyisonicotinaldehyde, 3-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-5-methoxyisonicotinaldehyde, 5-((2-(2-isopropyl-2H-1,2,4-triazol-3-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde, 5-((2-(1-isopropyl-4-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde, 5-((2-(1-(2-hydroxyethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde, 6-(((4-formylpyridin-3-yl)oxy)methyl)picolinic acid 2,2,2-trifluoroacetic acid: 6-(((4-formylpyridin-3-yl)oxy)methyl)picolinic acid (1:1), 2-methoxy-5-((2-(1-(((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-5-yl)pyridin-3-3-yl)methoxy)isonicotinaldehyde, 5-((2-(4-methyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy-2-oxy)-2-oxo-1,2-dihydropyridine-4-carbaldehyde, 5-((2-(1-cyclobutyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde, 5-((2-(1-cyclohexyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde, 5-((2-(1-cyclohexylmethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde, 5-((2-(1-cyclopentyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-2-methoxyisonicotinaldehyde, 2-(5-(3-((4-formyl-6-methoxypyridin-3-yloxy)methyl)pyridin-2-yl)-1H-pyrazol-1-yl)acetic acid, methyl 3-(5-(3-(((4-formyl-6-methoxypyridin-3-yl)oxy)methyl)pyridin-2-yl)-1H-pyrazol-1-yl)propanoate, 3-(3-(3-((4-formyl-6-methoxypyridin-3-yloxy)methyl)pyridin-2-yl)-1H-pyrazol-1-yl)propanoic acid, 3-(5-(3-(((4-formyl-6-methoxypyridin-3-yl)oxy)methyl)pyridin-2-yl)-1H-pyrazol-1-yl)propanoic acid, 3-(((4-formyl-6-methoxypyridin-3-yl)oxy)methyl)benzoic acid, 6-(((4-formylpyridin-3-yl)oxy)methyl)nicotinonitrile 2,2,2-trifluoroacetate, 6-(((4-formylpyridin-3-yl)oxy)methyl)nicotinic acid, 6-(((4-formylpyridin-3-yl)oxy)methyl)nicotinic acid hydrochloride, 6-(((4-formylpyridin-3-yl)oxy)methyl)-N-(methylsulfonyl)nicotinamide, 2,2,2-trifluoroacetic acid: 6-(((4-formylpyridin-3-yl)oxy)methyl)-N-(methylsulfonyl)nicotinamide (2:1), 2-(2-methoxyethoxy)-5-((2-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde, 2-methoxy-5-((2-(1-(3,3,3-trifluoropropyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde, 2-(2-methoxyethoxy)-5-((2-(1-(3,3,3-trifluoropropyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde, 2-methyl-5-((2-(1-(2,2,2-trifluoromethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde, 2-methyl-5-((2-(1-(3,3,3-trifluoropropyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde, 3-((2-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde, 3-((2-(1-(3,3,3-trifluoropropyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde, 3-chloro-5-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde, 3-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)-5-methylisonicotinaldehyde, 3-chloro-5-((2-(1-(3,3,3-trifluoropropyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde, and 3-methyl-5-((2-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)isonicotinaldehyde, or a tautomer or pharmaceutically acceptable salt thereof.Cited by (0)
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