Apparatus and methods for fluid processing and flow control

Abstract

Fluid processing apparatus has a prefabricated branched network of flexible tubing, for conducting process fluid between process elements of the apparatus, and control valves. A tubing support has opposable front and rear plates which define a pattern of support channels between them in which the flexible tubing network lies, so that the support channels limit or prevent expansion of the flexible tubes. Standard non-reinforced tubing can then be used for high-pressure work. The support body plates can be separated to open the channels for insertion or removal of the flexible tubing. The front plate may be transparent. The control valves operate by simply pressing on the tubing in the support channels to block flow, without invasion of the flow path. The tubing sets can be easily replaced, cleaned or sterilized. The invention is useful in a range of controlled-flow processes e.g. chromatography and filtration.

1 . Fluid processing apparatus comprising a flow network of tubular flow conduits of flexible elastic polymeric tubing, said network including plural branching points where three or more parts of the tubing meet, for conducting process fluid between processing elements of the apparatus, and which comprises one or more flow control mechanisms such as valves for controllably modifying the flow of fluid, characterised by a tubing support body defining a pattern of support channels in which all or part of the flexible tubing network is received, the corresponding pattern of support channels in the tubing support body including branching points corresponding to those of the tubing network, the flexible tubes of the tubing network lying in the support channel so that the support channel limits or prevents expansion of the flexible tube material. 
     
     
         2 . Fluid processing apparatus of  claim 1  in which the polymeric tubing is of outer diameter 5 to 30 mm. 
     
     
         3 . Fluid processing apparatus of  claim 1  in which the support body comprises opposed support body parts which define said channels between them and which can be separated to open the channels for insertion or removal of the flexible tubing, and closed together to enclose the flexible tubing closely in the channels. 
     
     
         4 . Fluid processing apparatus of  claim 3  in which a cavity forming each channel is defined partly by a groove in the face of one said opposed part of the support body and partly by a groove in the opposed face of the other. 
     
     
         5 . Fluid processing apparatus of  claim 3  in which said opposed parts are respectively front and rear plates, the front plate being transparent. 
     
     
         6 . Fluid processing apparatus of  claim 3  in which the separable opposed body parts of the support body are mounted in or on structure for controlling their movement relative to one another, and comprising guide mechanism engaging between the body parts to ensure that they come together in alignment. 
     
     
         7 . Fluid processing apparatus of  claim 1  in which the support body is of rigid plastics material. 
     
     
         8 . Fluid processing apparatus of  claim 1  in which the support body is provided on a fixed or mobile stand such as a skid, trolley or cabinet, or is mounted on a wall or ceiling. in correct alignment. 
     
     
         9 . Fluid processing apparatus of  claim 1  in which said one or more flow control mechanisms comprise one or more valves operable to press on the flexible tubing in a said support channel , compressing the tubing to block the flow. 
     
     
         10 . Fluid processing apparatus of  claim 9  in which the or each valve comprises a presser element housed or mounted in the support body, and movable relative to the support body across the support channel to a closed position in which it will compress a flexible tube in the channel to shut off flow, and an actuator to drive or control movement of the presser element across the support channel. 
     
     
         11 . Fluid processing apparatus of  claim 10  in which the valve presser element is formed as or with a rib or bar extending transversely over the support channel. 
     
     
         12 . Fluid processing apparatus of  claim 10  in which the valve actuator has an electrical, electromechanical, pneumatic, electromagnetic or manually-driven mechanism. 
     
     
         13 . Fluid processing apparatus of  claim 1  in which terminations of the flexible tubing emerging from the support body are encased in termination covers of plastic or metal to prevent their expansion under internal pressure. 
     
     
         14 . Fluid processing apparatus of  claim 13  in which the different termination covers are differently colour or symbol coded. 
     
     
         15 . Fluid processing apparatus of  claim 13  in which the termination covers engage mechanically in the support body to prevent the termination covers from turning in and/or escaping from the support body. 
     
     
         16 . Fluid processing apparatus of  claim 1  comprising, as one or more fluid processing elements connected to said flow network, any one or more of a pump, filter, bubble trap, mixing chamber, chromatography column, separation devices, heater, cooler, irradiation device, sensor, detector, flow gauge or flow meter. 
     
     
         17 . Combination of the tubing support body and flow control mechanisms for fluid processing apparatus as defined in  claim 1 . 
     
     
         18 . Processing method in which process fluid is passed through fluid processing apparatus of  claim 1 , optionally under raised pressure. 
     
     
         19 . Processing method of  claim 18  in which said process fluid passes through one or more fluid processing elements connected to said flow network of the apparatus, and comprising any one or more of a pump, filter, bubble trap, mixing chamber, chromatography column, separation devices, heater, cooler, irradiation device, sensor, detector, flow gauge or flow meter, and/or in which said process is a process of purification, capture, absorption, adsorption, desorption, partition, separation, filtration, ultrafiltration or chromatography. 
     
     
         20 . Processing method of  claim 18  comprising intermittently removing a said flow network of tubular flow conduits of flexible tubing from said support body, and/or inserting a said flow network of tubular flow conduits of flexible tubing in said support body.