Topical arginine-silicate-inositol for wound healing

Abstract

The present invention generally relates to compositions and methods for topical or transdermal delivery, for promoting wound healing, reducing scarring, and/or promoting hair growth. Specifically, the present disclosure is directed to a topical arginine silicate formulation that demonstrates surprising improvement in wound healing time leading to more advantageous recovery and reducing hospital costs. Such formulations may also lessen scarring. The formulations may, for example, be applied to skin or to mucous membranes to facilitate wound healing.

What is claimed is: 
     
         1 . A method for decreasing wound healing time comprising:
 applying a topical composition comprising an effective amount of arginine silicate inositol (“ASP”) to a wound, wherein the amount decreases wound healing time in comparison to not applying the composition.   
     
     
         2 . The method of  claim 1 , wherein the amount of ASI is between about 1% and about 10% of the composition by total weight. 
     
     
         3 . The method of  claim 1 , wherein the amount of ASI is about 4% of the composition by total weight. 
     
     
         4 . The method of  claim 1 , wherein the composition is selected from the group consisting of a gel, a cream, a lotion, an ointment, a salve, a balm, a foam, and combinations thereof. 
     
     
         5 . The method of  claim 1 , wherein the composition comprises a bandage or a patch. 
     
     
         6 . A method for decreasing wound scarring comprising:
 applying a topical composition comprising an effective amount of arginine silicate inositol (“ASP”) to a wound, wherein the amount decreases scarring from the wound in comparison to not applying the composition.   
     
     
         7 . The method of  claim 6 , wherein the amount of ASI is between about 1% and about 10% of the composition by total weight. 
     
     
         8 . The method of  claim 6 , wherein the amount of ASI is about 4% of the composition by total weight. 
     
     
         9 . The method of  claim 6 , wherein the composition is selected from the group consisting of a gel, a cream, a lotion, an ointment, a salve, a balm, a foam, and combinations thereof. 
     
     
         10 . The method of  claim 6 , wherein the composition comprises a bandage or a patch. 
     
     
         11 . A method for promoting hair growth comprising:
 applying a topical composition comprising an effective amount of arginine silicate inositol (“ASP”) to a treatment area on a mammalian subject, wherein the amount promotes hair growth in the treatment area in comparison to non-treatment areas.   
     
     
         12 . The method of  claim 11 , wherein the amount of ASI is between about 1% and about 10% of the composition by total weight. 
     
     
         13 . The method of  claim 12 , wherein the amount of ASI is about 4% of the composition by total weight. 
     
     
         14 . The method of  claim 11 , wherein the composition is selected from the group consisting of a gel, a cream, a lotion, an ointment, a salve, a balm, a foam, and combinations thereof. 
     
     
         15 . The method of  claim 11 , wherein the composition comprises a bandage or a patch. 
     
     
         16 . The method of  claim 15 , wherein the composition is selected from the group consisting of a shampoo, a conditioner, a leave-in conditioner, a mousse, a pomade, and a hair spray. 
     
     
         17 . A method for reducing inflammation comprising:
 applying a topical composition comprising an effective amount of arginine silicate inositol (“ASP”) to a treatment area on a mammalian subject, wherein amount reduces inflammation in the treatment area in comparison to non-treatment areas.   
     
     
         18 . The method of  claim 17 , wherein the amount reduces expression levels of a protein selected from the group consisting of NFκB, TGF-β, TNF- 60  , and IL-1β. 
     
     
         19 . The method of  claim 17 , wherein the amount of ASI is between about 1% and about 10% of the composition by total weight. 
     
     
         20 . A topical composition comprising between about 1% and about 10% ASI by total weight and at least one pharmaceutically acceptable excipient.