Occlusion perfusion catheter

Abstract

Catheters for occluding, visualizing, irrigating, evacuating, and delivering agents to a treatment area are disclosed. The catheters comprise a catheter body comprising five lumens, first and second occlusion balloons coupled to the catheter body, an optional space-occupying balloon coupled to the catheter body and disposed between the first and second occlusion balloons, and an optional visualization means that enables visualization between the first and second occlusion balloons. Methods for using these catheters are also disclosed. A method comprises inflating the first and second occlusion balloons, inflating the space-occupying balloon, allowing fluid to exit via an evacuation lumen, optionally irrigating or aspirating to facilitate fluid exit via said lumen, and delivering an agent to a treatment area via the agent lumen.

We claim: 
     
         1 . A catheter comprising:
 a) a catheter shaft having a distal end having a shaft distal tip and a proximal end;   b) a first balloon positioned on the shaft proximal to the shaft distal tip;   c) a second balloon positioned on the shaft proximal to the first balloon;   d) a third balloon positioned on the shaft proximal to the second balloon;   e) an agent delivery segment positioned on the shaft between the first and third balloons and having one orifice formed therein;   f) an aspiration segment positioned on the shaft between the first and third balloons and having one orifice formed therein; and   g) a guidewire lumen formed within the shaft and in communication with: an opening formed in a proximal end of the catheter; and an opening formed in a distal end of the catheter.   
     
     
         2 . The catheter of  claim 1 , further comprising a first pressure-sensing means having proximal and distal ends and a length therebetween, wherein said distal end is at or near the agent delivery segment orifice. 
     
     
         3 . The catheter of  claim 2 , wherein said first pressure-sensing means proximal end is in communication with a connector formed on the proximal end of the catheter shaft. 
     
     
         4 . The catheter of  claim 1 , further comprising a first inflation lumen in communication with the first and third balloons. 
     
     
         5 . The catheter of  claim 4 , wherein said first inflation lumen is further in communication with a first balloon inflation port formed on the proximal end of the catheter shaft. 
     
     
         6 . The catheter of  claim 1 , further comprising a second inflation lumen in communication with the second balloon. 
     
     
         7 . The catheter of  claim 6 , wherein said second inflation lumen is further in communication with a second balloon inflation port formed on the proximal end of the catheter shaft. 
     
     
         8 . The catheter of  claim 1 , further comprising an aspiration lumen in communication with the aspiration segment orifice. 
     
     
         9 . The catheter of  claim 8 , wherein said aspiration lumen is further in communication with an aspiration port formed on the proximal end of the catheter shaft. 
     
     
         10 . The catheter of  claim 9 , further comprising a valve in communication with said aspiration port. 
     
     
         11 . The catheter of  claim 1 , further comprising an agent delivery lumen in communication with the agent delivery segment orifice. 
     
     
         12 . The catheter of  claim 11 , wherein said agent delivery lumen is further in communication with an agent delivery port formed on the proximal end of the catheter shaft. 
     
     
         13 . The catheter of  claim 11 , further comprising a first pressure-sensing means having proximal and distal ends and a length therebetween, wherein said first pressure-sensing means proximal end is in communication with a connector formed on the proximal end of the catheter shaft and said first pressure-sensing means distal end is at or near the agent delivery segment orifice. 
     
     
         14 . The catheter of  claim 13 , further comprising a second pressure-sensing means having proximal and distal ends and a length therebetween, wherein said second pressure-sensing means proximal end is in communication with the connector formed on the proximal end of the catheter shaft and said second pressure-sensing means distal end is located within the agent delivery lumen. 
     
     
         15 . A catheter comprising:
 a) a catheter shaft having a distal end having a shaft distal tip and a proximal end;   b) a first balloon positioned on the shaft proximal to the shaft distal tip, a second balloon positioned on the shaft proximal to the first balloon, and a third balloon positioned on the shaft proximal to the second balloon;   c) a first inflation lumen in communication with the first and third balloons, wherein said first inflation lumen is further in communication with a first balloon inflation port formed on the proximal end of the catheter shaft;   d) a second inflation lumen in communication with the second balloon, wherein said second inflation lumen is further in communication with a second balloon inflation port formed on the proximal end of the catheter shaft;   e) an agent delivery segment positioned on the shaft between the second and third balloons and having one orifice formed therein, wherein the agent delivery lumen is in communication with the agent delivery segment orifice and an agent delivery port formed on the proximal end of the catheter shaft;   f) an aspiration segment positioned on the shaft between the first and second balloons and having one orifice formed therein, wherein the aspiration lumen is in communication with the aspiration segment orifice and an aspiration port formed on the proximal end of the catheter shaft, said aspiration port optionally further comprising a valve in communication with the aspiration port;   g) a guidewire lumen formed within the shaft and in communication with an opening formed in a proximal end of the catheter and an opening formed in a distal end of the catheter;   h) a first pressure-sensing means having proximal and distal ends and a length therebetween, wherein said first pressure-sensing means proximal end is in communication with a connector formed on the proximal end of the catheter shaft and said first pressure-sensing means distal end is at or near the agent delivery segment orifice; and   i) a second pressure-sensing means having proximal and distal ends and a length therebetween, wherein said second pressure-sensing means proximal end is in communication with the connector formed on the proximal end of the catheter shaft and said second pressure-sensing means distal end is located within the agent delivery lumen.   
     
     
         16 . A catheter comprising:
 a) a catheter shaft having a distal end having a shaft distal tip and a proximal end;   b) a first balloon positioned on the shaft proximal to the shaft distal tip;   c) a second balloon positioned on the shaft proximal to the first balloon;   d) an agent delivery segment positioned on the shaft between the first and second balloons and having one orifice formed therein;   e) an aspiration segment positioned on the shaft between the first and second balloons and having one orifice formed therein;   f) a visualization means, wherein said visualization means enables visualization between the first and second balloons; and   g) a guidewire lumen formed within the shaft and in communication with: an opening formed in a proximal end of the catheter; and an opening formed in a distal end of the catheter.   
     
     
         17 . The catheter of  claim 16 , further comprising a first inflation lumen in communication with the first and second balloons, wherein said first inflation lumen is further in communication with a first balloon inflation port formed on the proximal end of the catheter shaft. 
     
     
         18 . The catheter of  claim 16 , further comprising a visualization means lumen in communication with a visualization means slot and containing at least a portion of said visualization means. 
     
     
         19 . The catheter of  claim 16 , further comprising an aspiration lumen in communication with the aspiration segment orifice, wherein said aspiration lumen is further in communication with an aspiration port formed on the proximal end of the catheter shaft. 
     
     
         20 . The catheter of  claim 16 , further comprising an agent delivery lumen in communication with the agent delivery segment orifice wherein said agent delivery lumen is further in communication with an agent delivery port formed on the proximal end of the catheter shaft.