Piperidine Derivatives And Compositions For the Inhibition Of Nicotinamide Phosphoribosyltransferase (NAMPT)

Abstract

The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:

1 . A compound of Formula II: 
       
         
           
           
               
               
           
         
         wherein 
         W is —C(O)—, —S(O)—, or —S(O) 2 —; 
         R is an aryl or bicyclic heteroaryl;
 wherein said heteroaryl contains 1, 2, or 3 heteroatoms independently selected from N, S, and O; and 
 each of said aryl or heteroaryl is optionally substituted with one or more substituents which can be the same or different and are independently selected from the group consisting of deuterium, halo, cyano, amino, aminoalkyl, (amino)alkoxy, —CONH 2 , —C(O)NH(alkyl), —C(O)N(alkyl) 2 , —C(O)NH(aryl), —C(O)N(aryl) 2 , —CF 3 , —CHF 2 , —CH 2 F, -alkyl, alkoxy, hydroxyl, hydroxyalkyl, (alkoxyalkyl) amino, —N(R 3 )—C(O)-alkyl, —N(R 3 )—C(O)-aryl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, with the proviso that no two adjacent ring heteroatoms in said heteroaryl are both S or both O; 
 
         G is aryl, heteroaryl, cycloalkyl, heterocycloalkyl, or —NR 1 R 2 ;
 wherein each of said aryl, heteroaryl, heterocycloalkyl, and cycloalkyl is either unsubstituted or substituted with 1, 2, 3, or 4 substituents which can be the same or different and are independently selected from the group consisting of deuterium, halo, cyano, amino, aminoalkyl, (amino)alkoxy-, —CONH 2 , —C(O)NH(alkyl), —C(O)N(alkyl) 2 , —C(O)NH(aryl), —C(O)N(aryl) 2 , —CF 3 , —CHF 2 , —CH 2 F, alkyl, alkenyl, alkynyl, alkoxy, hydroxyl, hydroxyalkyl, aryloxy, (alkoxyalkyl)amino, —N(R 3 )—C(O)-alkyl, —N(R 3 )—C(O)-aryl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; and 
 R 1  and R 2  are the same or they are different, and are independently selected from H, C 1  to C 7  alkyl, C 1  to C 7  alkoxy, C 1  to C 4  hydroxyalkyl, aryl, heteroaryl, heterocycloalkyl, and cycloalkyl;
 wherein heteroatoms of said heteroaryl and heterocycloalkyl are independently selected from N, O, and S, with the proviso that no two adjacent ring heteroatoms are both S or both O; and 
 further wherein R 1  and R 2  are each unsubstituted or optionally substituted with one or more substituents which can be the same or different and are independently selected from the group consisting of deuterium, halo, cyano, amino, aminoalkyl, (amino)alkoxy, —CONH 2 , —C(O)NH(alkyl), —C(O)N(alkyl) 2 , —C(O)NH(aryl), —C(O)N(aryl) 2 , —CF 3 , —CHF 2 , —CH 2 F, alkyl, hydroxyalkyl, -alkoxy, hydroxyl, hydroxyalkyl, carboxy, (alkoxyalkyl) amino, -alkylamine, aminocarbonyl, —CHO, —N(R 3 )—C(O)-alkyl, —N(R 3 )—C(O)-aryl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; 
 
 
         R 3  is H, alkyl or arylalkyl; and 
         n is 4, 5 or 6; 
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         2 . The compound of  claim 1 , wherein W is —C(O)—. 
     
     
         3 . The compound of  claim 1 , wherein W is —S(O) 2 —. 
     
     
         4 . The compound of  claim 1 , wherein n is 4. 
     
     
         5 . The compound of  claim 1 , wherein R 3  is H. 
     
     
         6 . The compound of  claim 1 , wherein R is selected from the group consisting of thienopyridine, 1H-pyrrolopyridine, pyrrolopyridine, imidazopyridine, pyrazolopyridine, quinolone, and furopyridine, each optionally substituted. 
     
     
         7 . The compound of  claim 1 , wherein R is selected from the group consisting of thieno[2,3-c]pyridin-2-yl, 1H-pyrrolo[3,2-c]pyridin-2-yl, 1H-pyrrolo[3,2-c]pyridin-2-yl, imidazo[1,2-a]pyridin-6-yl, pyrazolo[3,4-b]pyridin-5-yl, quinolin-6-yl, and furo[2,3-c]pyridin-2-yl. 
     
     
         8 . The compound of  claim 1 , wherein G is selected from the group consisting of aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each optionally substituted. 
     
     
         9 . The compound of  claim 1 , wherein G is selected from the group consisting of phenyl, thiazole, pyridine, piperidine, imidazole, furan, oxazole, pyridine, cyclohexyl, indole, benzodioxolane, benzothiophene, benzothiazole, imidazopyridine, and aza-indole, each optionally substituted. 
     
     
         10 . The compound of  claim 1 , wherein G is selected from the group consisting of phenyl, thiazol-4-yl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, indol-2-yl, indol-6-yl, imidazol-2-yl, imidazol-4-yl, piperidin-4-yl, furan-3-yl, oxazol-4-yl, pyridin-2-yl, cyclohexyl, benzodioxolane, benzothiophene, benzothiazole, imidazol[1,2-a]pyridin-6-yl, and 1H-pyrrolo[3,2-c]pyridin-2-yl, each optionally substituted. 
     
     
         11 . The compound of  claim 1 , wherein G is substituted with 1-4 substituents selected from the group consisting of halo, amino, cyano, hydroxyl, alkyl, haloalkyl, alkoxy, acyl, haloalkoxy, aryl, heteroaryl, alkoxyalkyl, and mercapto. 
     
     
         12 . The compound of  claim 1 , wherein G is substituted with 1-3 substituents selected from the group consisting of halo, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, aryl, and heteroaryl. 
     
     
         13 . The compound of  claim 1 , wherein G is selected from the group consisting of imidazo[1,2-a]pyridine-6-yl, 1H-pyrrolo[3,2-c]pyridine, thieno[2,3-c]pyridin-2-yl, and furo[2,3-c]pyridin-2-yl, each optionally substituted. 
     
     
         14 . (canceled) 
     
     
         15 . The compound of  claim 1 , wherein G is thieno[2,3-c]pyridin-2-yl or imidazo[1,2-a]pyridine. 
     
     
         16 . (canceled) 
     
     
         17 . A compound selected from the group consisting of:
 N-(4-{1-[(3,5-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(3-fluoro-4-methoxybenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[2-(trifluoromethoxy)benzene]sulfonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[4-(trifluoromethyl)phenyl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide   N-[4-(1-{[6-(morpholin-4-yl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(dimethyl-1,3-thiazol-5-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-cyclohexanecarbonylpiperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[4-(propan-2-yloxy)phenyl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(2-fluorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(1H-indol-2-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(4-chloro-2-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(2,4-difluorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-{4-[1-(propane-2-sulfonyl)piperidin-4-yl]butyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[2-(2-methyl-1,3-thiazol-4-yl)acetyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(1-methyl-1H-imidazol-4-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(5-fluoropyridin-2-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(dimethyl-1,3-thiazol-5-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(2-fluoro-3-methylphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(3-ethoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(4-chlorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(4-fluorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(pyridin-3-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[4-(propan-2-yloxy)benzene]sulfonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(2,5-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(2,6-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(pyridin-4-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(3-fluorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(3-(1-benzoylpiperidin-4-yl)propyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(3-fluoro-2-methylphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[4-(difluoromethoxy)phenyl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(2,6-difluorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(2,3-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(4-chlorobenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(2-fluoro-5-methylbenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[2-(trifluoromethoxy)phenyl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide   N-[4-(1-{[5-(methoxymethyl)pyridin-2-yl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{4-[(1H-indol-2-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-[4-(1-{[4-(propan-2-yloxy)phenyl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{4-[(1H-indol-2-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(3-chlorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(2,6-difluorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{4-[(1H-indol-6-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(2,3-difluorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-[4-(1-benzoylazetidin-3-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(furan-3-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(2,3-difluorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(5-methylpyrazin-2-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(3-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(2-ethoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(2,3-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-cyclohexanecarbonylpiperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(5-chloro-2-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(2-ethoxypyridin-3-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-{4-[1-(benzenesulfonyl)piperidin-4-yl]butyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(3,5-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(3,4-difluorobenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(2,5-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[4-(difluoromethoxy)phenyl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(4-fluoro-3-methylbenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(5-methylpyrazin-2-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(2H-1,3-benzodioxol-5-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(2-fluorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(5-chloro-2-methoxypyridin-3-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(4-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(3-chloro-4-fluorobenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(4-methoxy-3-methylbenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[4-(trifluoromethyl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(3-fluoro-4-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(2,4-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-[4-(1-cyclohexanecarbonylpiperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(2,6-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-{[4-({4-[(pyrrolidin-1-yl)carbonyl]benzene}sulfonyl)phenyl]methyl}-1H-pyrazolo[3,4-b]pyridine-5-carboxamide   N-[4-(1-{[5-(methoxymethyl)pyridin-2-yl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(2,5-difluorobenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[4-(trifluoromethoxy)phenyl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide   N-[4-(1-{[6-(propan-2-yl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(3-fluorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(2,5-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(3,4-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(2-phenyl-1,3-thiazol-4-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(2-phenyl-1,3-thiazol-4-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-[4-(1-{[2-(trifluoromethyl)-1,3-thiazol-4-yl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(5-fluoropyridin-2-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(5-fluoro-2-methylphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[6-(morpholin-4-yl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(dimethyl-1,3-thiazol-5-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[2-(2-methyl-1,3-thiazol-4-yl)acetyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(2,5-dimethoxybenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(2,6-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(2-ethoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(3-fluoro-2-methylphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(5-fluoro-1H-indol-2-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[2-(1-methyl-1H-indol-3-yl)acetyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(4-fluoro-2-methylbenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(2-fluorobenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(3,4-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[4-(trifluoromethyl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(3,5-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(5-fluoro-2-methoxybenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(3-fluoro-4-methylphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(2,3-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(2,5-difluorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(3-cyanobenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(3-methoxybenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[6-(trifluoromethyl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(2-chlorobenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(3-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-{4-[1-(pyridine-3-sulfonyl)piperidin-4-yl]butyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[4-(trifluoromethyl)benzene]sulfonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(2-chlorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(3-fluoro-2-methylphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-[4-(1-{[4-(trifluoromethyl)phenyl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(2-chlorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[4-(trifluoromethoxy)benzene]sulfonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(3,4-difluorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(5-fluoro-1H-indol-2-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(5-fluoropyridin-2-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[2-(trifluoromethoxy)phenyl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(1H-indol-5-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(2,5-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(2-ethoxyphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(4-methoxybenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[2-(methylsulfanyl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[4-(difluoromethoxy)phenyl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(furan-3-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(2-methoxy-5-methylbenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(2H-1,3-benzodioxol-5-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(2,3-difluorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-{4-[1-({1H-pyrrolo[3,2-c]pyridin-2-yl}carbonyl)piperidin-4-yl]butyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[4-(trifluoromethyl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(4-methyl-1,3-thiazol-5-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-[4-(1-{[2-(trifluoromethyl)-1,3-thiazol-4-yl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(2,4-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[2-(trifluoromethoxy)phenyl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide   N-[2-(1-benzoylpiperidin-4-yl)ethyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-{4-[1-({1H-pyrrolo[3,2-c]pyridin-2-yl}carbonyl)piperidin-4-yl]butyl}thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(3-fluoro-4-methylphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(3-fluoro-4-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-[4-(1-{[5-(trifluoromethyl)pyridin-2-yl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(3,4-dimethoxybenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(4-methyl-1,3-thiazol-5-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(5-fluoro-1H-indol-2-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-[4-(1-{[2-(trifluoromethyl)pyrimidin-5-yl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(4-chloro-2-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(5-chloro-2-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(2,5-difluorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(6-methylpyridin-3-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(4-fluorobenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(1-benzothiophen-2-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-[4-(1-{[2-(methylsulfanyl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(pyridin-2-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-[4-(1-{[5-(trifluoromethyl)pyridin-2-yl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(1,3-benzothiazol-6-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(1-methyl-1H-imidazol-4-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(4-methyl-1,3-thiazol-5-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-{[4-({4-[(pyrrolidin-1-yl)carbonyl]benzene}sulfonyl)phenyl]methyl}furo[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(1,3-benzothiazol-6-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(3-fluorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[2-(4-phenylphenyl)ethyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-{4-[1-(5-methyl-1,2-oxazole-4-sulfonyl)piperidin-4-yl]butyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(3,4-difluorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(2,5-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[5-(trifluoromethyl)pyridin-2-yl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(pyridin-3-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(2,4-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-[4-(1-{[6-(propan-2-yl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(1H-indol-6-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(2-methylpyridin-3-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(2,4-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-benzoylpiperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(4-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(2,5-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(2-chlorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(2-methylpyridin-3-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(3-fluorobenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(2-fluorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-[4-(1-{[4-(propan-2-yl)-1,3-oxazol-5-yl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(2-methyl-1,3-thiazol-4-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(2-fluoro-3-methylphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(3-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(3,5-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-[4-(1-{[6-(propan-2-yl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(1-methyl-1H-indol-2-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[5-(propan-2-yl)pyridin-2-yl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(2,4-difluorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(2,4-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-[4-(1-benzoylpiperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(3-chlorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[2-(pyridin-3-yl)-1,3-thiazol-4-yl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(2-ethoxypyridin-3-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(3-ethoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(2,4-dimethoxybenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(2,5-difluorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[2-(1-methyl-1H-indol-3-yl)acetyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[4-(trifluoromethoxy)phenyl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide   N-{4-[1-({1H-pyrrolo[3,2-c]pyridin-2-yl}carbonyl)piperidin-4-yl]butyl}imidazo[1,2-a]pyridine-6-carboxamide   N-[6-(4-chlorophenoxy)hexyl]quinoline-6-carboxamide   N-(4-{1-[(2-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(4-benzoylpiperazin-1-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(5-chloro-2-methoxypyridin-3-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{4-[(3-methoxyphenyl)carbonyl]piperazin-1-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(3-fluoro-4-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(5-chloro-2-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(2,6-difluorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-{4-[1-({imidazo[1,2-a]pyridin-6-yl}carbonyl)piperidin-4-yl]butyl}imidazo[1,2-a]pyridine-6-carboxamide   N-[4-(1-{[5-(methoxymethyl)pyridin-2-yl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide   N-[4-(1-{[3-(trifluoromethyl)benzene]sulfonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(3-chlorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(3,5-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(pyridin-2-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[2-(pyridin-3-yl)-1,3-thiazol-4-yl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(1-methyl-1H-indol-2-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(2-methylbenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(1-methyl-1H-indol-2-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-[4-(1-{[4-(trifluoromethoxy)phenyl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[2-(trifluoromethyl)-1,3-thiazol-4-yl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(3-fluoro-4-methylphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(2H-1,3-benzodioxol-5-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(3,4-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(2,4-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-{[4-({4-[(pyrrolidin-1-yl)carbonyl]benzene}sulfonyl)phenyl]methyl}thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(pyridin-3-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(4-chloro-2-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(3,4-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(3,5-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-(benzyloxy) phenethyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(6-methylpyridin-3-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-[4-(1-{[5-(propan-2-yl)pyridin-2-yl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(3-ethoxyphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-[4-(1-{[2-(trifluoromethyl)benzene]sulfonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[2-(2-methyl-1,3-thiazol-4-yl)acetyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(3,4-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(1-benzothiophen-2-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[4-(1H-pyrazol-1-yl)phenyl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(3-chlorobenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[6-(trifluoromethyl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(2-methyl-1,3-thiazol-4-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[5-(propan-2-yl)pyridin-2-yl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(4-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-{4-[1-({thieno[2,3-c]pyridin-2-yl}carbonyl)piperidin-4-yl]butyl}thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(3,5-difluorobenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(3-chloro-4-methoxybenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(2,3-dimethoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(3,4-difluorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(2,4-difluorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(2-fluoro-3-methylphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(4-chlorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-[4-(1-{[4-(1H-pyrazol-1-yl)phenyl]carbonyl}piperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide   N-{4-[1-(1-methyl-1H-pyrazole-3-sulfonyl)piperidin-4-yl]butyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(6-methylpyridin-3-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(2-ethoxypyridin-3-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-benzoylpiperidin-4-yl)butyl]imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(1H-indol-6-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(2-methoxyphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(2,3-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(2-methyl-1,3-thiazol-4-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-{2-[1-(benzenesulfonyl)piperidin-4-yl]ethyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[4-(propan-2-yl)-1,3-oxazol-5-yl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide   N-{4-[1-({imidazo[1,2-a]pyridin-6-yl}carbonyl)piperidin-4-yl]butyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(3-fluoro-4-methylbenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(4-methylbenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(3-fluoro-2-methylbenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(3,4-dichlorophenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-[4-(1-{[4-(propan-2-yloxy)phenyl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide   N-[4-(1-{[4-(1H-pyrazol-1-yl)phenyl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[2-(trifluoromethyl)pyrimidin-5-yl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(5-fluoro-2-methylphenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-[4-(1-{[2-(methylsulfanyl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(2-phenyl-1,3-thiazol-4-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-[4-(1-{[2-(pyridin-3-yl)-1,3-thiazol-4-yl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(5-methylpyrazin-2-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{1-[(1,3-benzothiazol-6-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-(4-{4-[(3-chlorophenyl)carbonyl]piperazin-1-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(1H-indol-5-yl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(1-benzothiophen-2-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-[4-(1-{[3-(trifluoromethoxy)benzene]sulfonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[2-(1-methyl-1H-indol-3-yl)acetyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(furan-3-yl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   N-[4-(1-{[6-(trifluoromethyl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(4-cyanobenzene)sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(1-methyl-1H-imidazol-2-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[6-(morpholin-4-yl)pyridin-3-yl]carbonyl}piperidin-4-yl)butyl]thieno[2,3-c]pyridine-2-carboxamide   N-[4-(1-{[4-(trifluoromethyl)phenyl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(1H-indol-5-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(4-fluorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[(4-chlorophenyl)carbonyl]piperidin-4-yl}butyl)thieno[2,3-c]pyridine-2-carboxamide   N-(4-{1-[6-(trifluoromethyl)pyridine-3-sulfonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(3-(1-benzoylpiperidin-4-yl)butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(4-fluorophenyl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-[4-(1-{[4-(propan-2-yl)-1,3-oxazol-5-yl]carbonyl}piperidin-4-yl)butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide   N-(4-{1-[(5-chloro-2-methoxypyridin-3-yl)carbonyl]piperidin-4-yl}butyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide and   N-(4-{1-[(5-fluoro-2-methylphenyl)carbonyl]piperidin-4-yl}butyl)imidazo[1,2-a]pyridine-6-carboxamide   and pharmaceutically acceptable salts thereof.   
     
     
         18 . A pharmaceutical composition comprising at least one compound of  claim 1 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier. 
     
     
         19 - 20 . (canceled) 
     
     
         21 . A method of treating, preventing, inhibiting, or eliminating a disease or condition in a patient by administering a therapeutically effective amount of at least one compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein said disease or condition is selected from the group consisting of cancer, ovarian cancer, breast cancer, uterine cancer, colon cancer, cervical cancer, lung cancer, prostate cancer, skin cancer, bladder cancer, pancreatic cancer, leukemia, lymphoma, Hodgkin's disease, viral infections, Human Immunodeficiency Virus, hepatitis virus, herpes virus, herpes simplex, inflammatory disorders, irritable bowel syndrome, inflammatory bowel disease, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, osteoarthritis, osteoporosis, dermatitis, atoptic dermatitis, psoriasis, systemic lupus erythematosis, multiple sclerosis, psoriatic arthritis, ankylosing spondylitis, graft-versus-host disease, Alzheimer's disease, cerebrovascular accident, atherosclerosis, diabetes, glomerulonephritis, metabolic syndrome, non-small cell lung cancer, small cell lung cancer, multiple myeloma, squamous cell cancers, kidney cancer, urethral and bladder cancers, cancers of head and neck, and cancers of the brain and central nervous system. 
     
     
         22 . (canceled) 
     
     
         23 . The method of  claim 21 , wherein said disease or condition is a cancer. 
     
     
         24 . The method of  claim 23 , wherein said cancer is selected from the group consisting of leukemia, lymphoma, ovarian cancer, breast cancer, uterine cancer, colon cancer, cervical cancer, lung cancer, prostate cancer, skin cancer, CNS cancer, bladder cancer, pancreatic cancer, and Hodgkin's disease. 
     
     
         25 . The pharmaceutical composition of  claim 18 , further comprising one or more additional therapeutic agents. 
     
     
         26 . The pharmaceutical composition of  claim 25 , wherein said one or more additional therapeutic agents are selected from the group consisting of cytotoxic agent, cisplatin, doxorubicin, taxotere, taxol, etoposide, irinotecan, camptostar, topotecan, paclitaxel, docetaxel, the epothilones, tamoxifen, 5-fluorouracil, methotrexate, temozolomide, cyclophosphamide, SCH 66336, tipifarnib (Zarnestra®), R115777, L778,123, BMS 214662, Iressa®, Tarceva®, C225, GLEEVEC®, Intron®, Peg-Intron®, aromatase combinations, ara-C, adriamycin, cytoxan, gemcitabine, Uracil mustard, Chlormethine, Ifosfamide, Melphalan, Chlorambucil, Pipobroman, Triethylenemelamine, Triethylenethiophosphoramine, Busulfan, Carmustine, Lomustine, Streptozocin, Dacarbazine, Floxuridine, Cytarabine, 6-Mercaptopurine, 6-Thioguanine, Fludarabine phosphate, oxaliplatin, oxaliplatin (ELOXATIN®), Pentostatine, Vincristine, Vindesine, Bleomycin, Dactinomycin, Daunorubicin, Epirubicin, Idarubicin, Mithramycin™, Deoxycoformycin, Mitomycin-C, L-Asparaginase, Teniposide, 17α-Ethinylestradiol, Diethylstilbestrol, Testosterone, Prednisone, Fluoxymesterone, Dromostanolone propionate, Testolactone, Megestrol acetate, Methylprednisolone, Methyltestosterone, Prednisolone, Triamcinolone, Chlorotrianisene, Hydroxyprogesterone, Aminoglutethimide, Estramustine, Medroxyprogesteroneacetate, Leuprolide, Flutamide, Toremifene, goserelin, Hydroxyurea, Amsacrine, Procarbazine, Mitotane, Mitoxantrone, Levamisole, Navelbene, Anastrazole, Letrazole, Capecitabine, Reloxafine, Droloxafine, Hexamethylmelamine, Avastin, herceptin, Bexxar, Velcade, Zevalin, Trisenox, Xeloda, Vinorelbine, Porfimer, Erbitux, Liposomal, Thiotepa, Altretamine, Trastuzumab, Lerozole, Fulvestrant, Exemestane, Ifosfomide, Rituximab, Campath, leucovorin, and dexamethasone, bicalutamide, carboplatin, chlorambucil, letrozole, megestrol, valrubicin, and vinblastine. 
     
     
         27 . The pharmaceutical composition of  claim 18  further comprising a rescuing agent. 
     
     
         28 . The pharmaceutical composition of  claim 27 , wherein the rescuing agent is selected from the group consisting of nicotinamide, nicotinic acid, and nicotinamide mononucleotide (NMN).