Hydrophobic ceragenin compounds and devices incorporating same

Abstract

A hydrophobic cationic steroidal anti-microbial (ceragenin) compound forms an amphiphilic compound having a hydrophobic sterol face and a hydrophilic cationic face. Medical devices can be made incorporating the ceragenin compound.

What is claimed is: 
     
         1 . A cationic steroidal anti-microbial (CSA) compound selected from the group consisting of: 
       
         
           
           
               
               
           
         
       
       and
 salts thereof. 
 
     
     
         2 . The CSA compound of  claim 1 , wherein the CSA compound is a hydrochloride salt. 
     
     
         3 . A cationic steroidal anti-microbial (CSA) compound selected from the group consisting of: 
       
         
           
           
               
               
           
         
       
       and
 salts thereof. 
 
     
     
         4 . A cationic steroidal anti-microbial (CSA) compound selected from the group consisting of: 
       
         
           
           
               
               
           
         
       
       and
 salts thereof. 
 
     
     
         5 . A device comprising a polymer structure and the CSA compound of  claim 1  incorporated into the polymer structure. 
     
     
         6 . The device of  claim 5 , wherein the CSA compound is incorporated into the polymer structure with non-covalent interactions. 
     
     
         7 . The device of  claim 5 , wherein the polymer structure comprises polyvinyl alcohol, sodium polyacrylate, an acrylate polymer, polyethylene oxide, polyAMPS, polyvinylpyrrolidone, polyacrylamide, silicone, agarose, methylcellulose, hyaluronan, or a combination thereof. 
     
     
         8 . The device of  claim 5 , wherein the device comprises a medical device. 
     
     
         9 . The device of  claim 8 , wherein the medical device is selected from the group consisting of bone implant, bone pin, bone screw, tissue graft, endotracheal tube, coronary stent, peripheral stent, catheter, arterio-venous graft, by-pass graft, pacemaker or defibrillator lead, anastomotic clip, arterial closure device, patent foramen ovale closure device, and drug delivery balloon. 
     
     
         10 . The device of  claim 5 , wherein the polymer structure includes a polymer coated on a substrate. 
     
     
         11 . The device of  claim 5 , wherein the hydrophobic CSA compound elutes from the polymer structure in excess saline water at a rate of 0.1-100 μg/ml at 3 days and/or over a period of 3 days. 
     
     
         12 . The device of  claim 5 , wherein the hydrophobic CSA compound elutes from the polymer structure in excess saline water at a rate of 0.5-50 μg/ml at one week and/or over a period of one week. 
     
     
         13 . The device of  claim 5 , wherein the hydrophobic CSA compound elutes from the polymer structure in excess saline water at a rate of 1-10 μg/ml at one month and/or over a period of one month.