Pyrazine derivatives as enac blockers

Abstract

Compounds of Formula I: and pharmaceutically acceptable salts and solvates thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 have the meanings as indicated in the specification, are useful for treating diseases mediated by blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

1 - 12 . (canceled) 
     
     
         13 . A method for treating chronic bronchitis comprising administering an effective amount of the following compound 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, to a subject in need of such treatment. 
     
     
         14 . The method according to  claim 13  wherein the compound is a pharmaceutically acceptable salt.