Adenosine receptor agonists and antagonists to modulate t cell responses

Abstract

Described are uses of A 2a adenosine receptor antagonists and agonists to provide long term modulation of immune responses. A 2a receptor antagonists in particular are provided to enhance immune responses by reducing T-cell mediated tolerance to antigenic stimuli and agonists are provided to enhance effectiveness of immunosuppressive agents. The application provides methods of treatment and prevention based on the long term effects of the compounds on T cell responses.

1 . A method of enhancing an immune response in a host, comprising administering to the host an A 2a  receptor antagonist in combination or alternation with a checkpoint inhibitor. 
     
     
         2 . The method of  claim 1 , wherein the checkpoint inhibitor blocks the action of PD-1 or Lag-3. 
     
     
         3 . The method of  claim 1 , wherein the checkpoint inhibitor is B7-H4 or a fragment thereof.