Biological products

Abstract

There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human CD22. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a modified CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by cells expressing CD22.

1 - 18 . (canceled) 
     
     
         19 . An antibody molecule having specificity for human CD22 comprising a heavy chain and a light chain wherein the variable domains comprise the amino acid sequences of SEQ ID NO:1 for CDR-H1; SEQ ID NO:3 for CDR-H3; SEQ ID NO:4 for CDR-L1; SEQ ID NO:5 for CDR-L2; and SEQ ID NO:6 for CDR-L3. 
     
     
         20 . The antibody molecule of  claim 19 , which is a CDR-grafted antibody molecule. 
     
     
         21 . The antibody molecule of  claim 19 , wherein the variable domain comprises human acceptor framework regions and non-human donor CDRs. 
     
     
         22 . A composition comprising the antibody molecule of any one of  claims 19 - 21 . 
     
     
         23 . The composition according to  claim 22 , comprising a pharmaceutically acceptable excipient, diluent, or carrier. 
     
     
         24 . The composition according to  claim 22 , additionally comprising anti-T cell, anti-IFNγ, anti-LPS antibodies, or a non-antibody ingredient.