Amide dendrimer compositions

Abstract

Amide compounds, amide polymers, compositions including amide compounds and amide polymers may be used to bind target ions, such as phosphorous-containing compounds in the gastrointestinal tract of animals. In some cases, amide compounds and amide polymers may include a core derived from an amide polyol and an organic polyacid or ester.

1 - 100 . (canceled) 
     
     
         101 . An amide polymer comprising:
 a) at least one amide compound or residue thereof, said amide compound represented by the following Formula I:   
       
         
           
           
               
               
           
         
         
           wherein
 n independently represents an integer from 0-20; 
 R independently represents a hydrogen radical, a hydroxyl radical, —OR 3 , —R 2 OH, —R 2 OR 3 , or C(O)N(R 1 ) 2 ; 
 R 1  independently represents a hydrogen radical, a hydroxyl radical, —OR 3 , or a branched or unbranched, substituted C 1 -C 10  alkyl radical wherein one or more carbon atoms of said alkyl radical is partially or fully substituted with —OH and/or —OR 3  groups; 
 R 2  independently represents a substituted or unsubstituted, branched or unbranched alkyl; and 
 R 3  is independently represented by the following Formula II: 
 
         
       
       
         
           
           
               
               
           
         
         
           
             wherein 
             p, q and r independently represent an integer from 0-2; 
             R 4  independently represents, 
           
         
       
       
         
           
           
               
               
           
         
         
           
             wherein
 m independently represents an integer from 1-20; 
 R 5  independently represents a hydrogen radical; a substituted or un-substituted alkyl radical; a substituted or un-substituted aryl radical; or R 5  and a neighboring R 5  together represent a link or links comprising a residue of a crosslinking agent, a substituted or un-substituted alicyclic radical, a substituted or un-substituted aromatic radical, or a substituted or un-substituted heterocyclic radical; or R 5  represents a link with another compound; and 
 
           
         
         b) a crosslinking agent or residue thereof. 
       
     
     
         102 . The amide polymer according to  claim 101 , wherein the amide compound is derived from an organic polyacid selected from the group consisting of methanetetracarboxylic acid, oxalic acid, malonic acid, succinic acid, fumaric acid, maleic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, tartaric acid, glucaric acid, mucic acid, galactaric acid, xylaric acid, aspartic acid, and 2-amino malonic acid. 
     
     
         103 . The amide polymer according to  claim 101 , wherein the amide compound is derived from an aldaric acid having the general formula HOOC—(CHOH) w —COOH wherein w represents an integer from 1 to 20. 
     
     
         104 . The amide polymer according to  claim 101 , wherein the amide compound is represented by the following Formula III: 
       
         
           
           
               
               
           
         
       
     
     
         105 . The amide polymer according to  claim 101 , wherein the amide compound is represented by the following Formula IV: 
       
         
           
           
               
               
           
         
       
     
     
         106 . The amide polymer according to  claim 101 , wherein the amide compound is represented by the following Formula V: 
       
         
           
           
               
               
           
         
       
     
     
         107 . The amide polymer according to  claim 101 , wherein the amide compound is represented by the following Formula VI: