Treatment of prostate cancer

Abstract

Described herein are compounds, methods of making such compounds, pharmaceutical compositions, and medicaments comprising such compounds, and methods of using such compounds to treat androgen receptor mediated diseases or conditions. The present invention provides therapies and therapeutic regimens for the treatment of prostate cancer.

1 - 52 . (canceled) 
     
     
         53 . A method of manufacturing a pharmaceutical composition, the method comprising steps of:
 preparing the pharmaceutical composition comprising an effective amount of Compound (1):   
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof, 
         from a crystalline form of Compound (1), wherein the crystalline form of Compound (1) is characterized by a powder X-ray diffraction pattern having characteristic peaks expressed in angle 2-theta at about 13.1° and about 14.1°. 
       
     
     
         54 . The method of  claim 53 , wherein some or all of the Compound (1) in the pharmaceutical composition is in the crystalline form. 
     
     
         55 . The method of  claim 54 , wherein some or all of the Compound (1) in the pharmaceutical composition is in amorphous form. 
     
     
         56 . The method of  claim 53 , wherein some or all of the Compound (1) in the pharmaceutical composition is in amorphous form. 
     
     
         57 . The method of  claim 53 , wherein the step of preparing comprises formulating for oral delivery. 
     
     
         58 . The method of  claim 57 , wherein the formulating for oral delivery comprises formulating as a tablet 
     
     
         59 . The method of  claim 58 , wherein the formulating as a tablet comprises
 combining the crystalline form of Compound (1) with a pharmaceutically acceptable carrier or excipient; and   compressing the combination.   
     
     
         60 . The method of  claim 53 , wherein the step of preparing comprises formulating for local administration. 
     
     
         61 . The method of  claim 60 , wherein the formulating for local administration comprises formulating for injection. 
     
     
         62 . The method of  claim 53 , wherein the step of preparing comprises formulating for rapid release. 
     
     
         63 . The method of  claim 53 , wherein the step of preparing comprises formulating for extended release. 
     
     
         64 . The method of  claim 53 , wherein the step of preparing comprises formulating for intermediate release. 
     
     
         65 . The method of  claim 53 , wherein the step of preparing comprises combining with at least one pharmaceutically acceptable chemical component selected from: a carrier, a stabilizer, a diluent, a dispersing agent, a suspending agent, a thickening agent, and/or an excipient. 
     
     
         66 . The method of  claim 65 , wherein the at least one pharmaceutically acceptable chemical component is a carrier and/or an excipient. 
     
     
         67 . The method of  claim 66  wherein the step of preparing comprises formulating into a solid, a semi-solid, or a liquid. 
     
     
         68 . The method of  claim 67 , wherein the step of preparing comprises formulating into a solid. 
     
     
         69 . The method of  claim 68 , wherein the formulating comprises formulating the solid into a solution, a suspension, or an emulsion. 
     
     
         70 . The method of  claim 53 , wherein the step of preparing comprises mixing, dissolving, granulating, dragee-making, levigating, emulsifying, encapsulating, entrapping, or compressing the Compound (1).