Compact Multimodality Optical Coherence Tomography Imaging Systems

Abstract

Systems for imaging a sample are provided. The system includes an OCT imaging portion having an associated OCT path defined by one set of optical elements between an OCT signal delivery optical fiber and the sample; an image capture portion having an associated image capture path defined by a second set of optical elements between an image capture device and the sample; and an illuminator portion having an associated illumination path defined by a third set of optical elements between an illumination source and the sample. The OCT path, the image capture path, and the illuminator path have at least one optical element in common, and the respective paths differ from each other by at least one optical element. The illumination path includes a multi-wavelength source of optical radiation.

That which is claimed is: 
     
         1 . A system for multimodal hyperspectral imaging of a subject, the system comprising:
 two imaging paths, a scanning beam optical coherence tomography (OCT) imaging path and a hyperspectral digital imaging path, wherein the scanning beam OCT imaging path comprises:   a source of broadband optical radiation;   a beamsplitter dividing the source of broadband optical radiation into a reference path and a sample path; and   a beamsplitter that mixes source light reflected from the subject in the sample path with source light returned from a reference reflector in the reference path to create a wavelength dependent interferogram directed along a detection path to a detection module;   wherein the hyperspectral digital imaging path comprises:   an illumination path including a source of optical radiation for illuminating the sample;   an image capture path including a wide field digital image capture device for capturing an image of the subject, wherein the image is responsive to the illumination of the subject, wherein the wide field digital image capture device is one of a color and a monochrome camera;   a wavelength-selective element along the image capture path preceding the image capture device;   a beam combiner for coupling the illumination path with the image capture path;   a dichroic beamsplitter configured to couple the scanning beam OCT imaging path and the digital imaging path, wherein the scanning beam OCT imaging path and the digital imaging path share a common objective lens; and   wherein digital image acquisition includes acquisition of a series of two or more images selectively responsive to selected wavelengths.   
     
     
         2 . The system of  claim 1 , wherein the illumination comprises broadband illumination within a range of from about 400 nm to about 740 nm. 
     
     
         3 . The system of  claim 2 , wherein the wide field digital image capture device is configured to capture a sequence of one or more wavelength-selected digital images and create one of a full color, pseudo color, and monochromatic image of an illuminated region. 
     
     
         4 . The system of  claim 3 , wherein an illumination wavelength range comprises a fluorescence excitation wavelength based on a sample and wavelength selection within the image capture path passes a fluorescence emission signal to the image capture device. 
     
     
         5 . The system of  claim 4 , further comprising a display to compare an OCT image to one or more spectrally filtered digital images.