Method for treating retinal conditions using an intraocular tamponade

Abstract

Composition comprising at least one fatty acid glycerol ester for use during or after a vitrectomy procedure, said composition being bioresorbable, being injectable in the vitreous cavity, having a density below 1, more preferably comprised between 0.90 and 1, or a density above 1 more preferably between 1 and 1.5; having a surface tension of less than 50 dynes/cm more preferably ranging from 20 and 30 dynes/cm, being not susceptible to emulsify into droplets when injected; method for treating a retinal disorder involving the use of said composition.

1 . A composition comprising at least one fatty acid glycerol ester, wherein the composition is further defined as:
 having a surface tension of less than 50 dynes/cm;   being bioresorbable; and   injectable in a vitreous cavity during or after a vitrectomy procedure.   
     
     
         2 . The composition of  claim 1 , further defined as having a surface tension ranging from 20 to 30 dynes/cm. 
     
     
         3 . The composition of  claim 1 , further defined as having a density below 1.0. 
     
     
         4 . The composition of  claim 3 , further defined as having a density between 0.90 and 1. 
     
     
         5 . The composition of  claim 1 , further defined as having a density adapted for treating a detachment of a lower portion of a retina that is above 1. 
     
     
         6 . The composition of  claim 5 , further defined as having a density between 1 and 1.5. 
     
     
         7 . The composition of  claim 1 , further defined as having a dynamic viscosity ranging from 20 to 60 mPa·s at a temperature of 20° C. 
     
     
         8 . The composition of  claim 7 , further defined as having a dynamic viscosity ranging from 25 to 55 mPa·s at a temperature of 20° C. 
     
     
         9 . The composition of  claim 8 , further defined as having a dynamic viscosity ranging from 27 to 33 mPa·s at a temperature of 20° C. 
     
     
         10 . The composition of  claim 1 , further defined as having a refractive index ranging from 1.40 to 
     
     
         1 . 50. 
     
     
         11 . The composition of  claim 10 , further defined as having a refractive index ranging from 1.44 to 1.46. 
     
     
         12 . The composition of  claim 11 , further defined as having a refractive index ranging from 1.449 to 1.451. 
     
     
         13 . The composition of  claim 1 , further comprising at least one lipophilic therapeutic agent. 
     
     
         14 . The composition of  claim 1 , further comprising at least one lipophilic therapeutic agent and at least one bioresorbable fatty acid glycerol ester, wherein the composition is a solution comprising at least 90% w/w of C6-C20 glycerol ester, in weight to weight of total composition, a therapeutic agent in an amount of more than 0 to 5.9% w/w, in weight to weight of total composition, with the therapeutic agent being dissolved in the fatty acid glycerol ester. 
     
     
         15 . The composition of  claim 14 , wherein the bioresorbable fatty acid glycerol ester is further defined as a non-water miscible C6-C20 glycerol ester. 
     
     
         16 . The composition of  claim 1 , wherein the fatty acid glycerol ester is a medium-chain triglyceride. 
     
     
         17 . A method of treating a retinal disorder comprising:
 obtaining a composition of  claim 1 ; and   administering it to a patient.